-
公开(公告)号：US20170128571A1
公开(公告)日：2017-05-11
申请号：US15160944
申请日：2016-05-20
Applicant: Pulse Therapeutics, Inc.
Inventor： Francis M. Creighton
CPC classification number: A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
-
2.发明申请公开(公告)号：US20150230810A1
公开(公告)日：2015-08-20
申请号：US14400999
申请日：2013-05-13
Applicant: PULSE THERAPEUTICS, INC.
Inventor： Francis M. Creighton , Michael Sabo , Christopher Null , Gerard Epplin , James Christopher Wachtman
CPC classification number: A61B17/22 , A61B17/22004 , A61B17/22012 , A61B17/32002 , A61B17/3207 , A61B2017/00345 , A61B2017/00876 , A61B2017/22084 , A61B2017/320004 , A61K41/0028 , A61M37/00 , A61M2037/0007 , B82Y5/00 , H01F7/0226 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.
Abstract translation: 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个实施例中，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 提供了具有非专门化学涂层的磁性纳米颗粒，其在输注之前促使使用者与化学成分相关联。 提供系统用于将一致的输注质量的磁性纳米颗粒递送给患者。
-
公开(公告)号：US08926491B2
公开(公告)日：2015-01-06
申请号：US14020173
申请日：2013-09-06
Applicant: Pulse Therapeutics, Inc.
Inventor： Francis M. Creighton
CPC classification number: A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
Abstract translation: 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
-
4.发明授权公开(公告)号：US08715150B2
公开(公告)日：2014-05-06
申请号：US13505447
申请日：2010-11-02
Applicant: Francis M. Creighton
Inventor： Francis M. Creighton
CPC classification number: A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
Abstract: The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
Abstract translation: 本发明涉及一种用于使用远程放置的产生磁场的定子在循环系统中物理地操纵自由磁转子的系统。 一方面，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。
-
公开(公告)号：US08603501B2
公开(公告)日：2013-12-10
申请号：US13891362
申请日：2013-05-10
Applicant: Bind Therapeutics, Inc.
Inventor： Stephen E. Zale , Mir Mukkaram Ali
IPC: A61K9/00 , A61K9/51 , A61K31/74 , A61K9/14 , C07C229/00
CPC classification number: A61K9/1647 , A61K9/146 , A61K9/5153 , A61K9/5192 , A61K31/136 , A61K31/197 , A61K31/337 , A61K31/704 , A61K47/34 , A61K47/542 , A61K47/60 , A61K47/6935 , A61K47/6937 , B82Y5/00 , C07C275/16 , C07C275/24 , C08G63/664 , C08G63/6852 , C08G63/6922 , Y10S977/904 , Y10S977/905 , Y10S977/906 , Y10S977/911 , Y10S977/915
Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
-
Patent Agency Ranking
公开(公告)号：US20120150109A1
公开(公告)日：2012-06-14
申请号：US13402141
申请日：2012-02-22
Applicant: Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, JR. , Jan Weber
Inventor： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, JR. , Jan Weber
IPC: A61M25/10
CPC classification number: A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
Abstract: The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
Abstract translation: 本发明提供包含纳米复合材料的医疗装置。 通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。 还提供了制造本发明的医疗装置的方法。 由于本发明的装置预期在使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。
-
公开(公告)号：US08182807B2
公开(公告)日：2012-05-22
申请号：US12033353
申请日：2008-02-19
Applicant: Vinod D. Labhasetwar , Maram K. Reddy
Inventor： Vinod D. Labhasetwar , Maram K. Reddy
IPC: A61K38/44
CPC classification number: A61K38/446 , A61K9/5138 , A61K9/5153 , A61K31/07 , A61K31/355 , A61K31/375 , C12Y115/01001 , Y10S977/904 , Y10S977/905 , Y10S977/906
Abstract: The present invention relates to a method for inhibiting reperfusion injury in the brain. The method involve injecting via the carotid artery or jugular vein an antioxidant-loaded nanoparticle. A nanoparticle formulation containing an inert plasticizer is also provided for sustained release of an active agent.
Abstract translation: 本发明涉及一种抑制脑内再灌注损伤的方法。 该方法包括通过颈动脉或颈静脉注射负载抗氧化剂的纳米颗粒。 还提供含有惰性增塑剂的纳米颗粒制剂用于活性剂的持续释放。
-
公开(公告)号：US20110300221A1
公开(公告)日：2011-12-08
申请号：US13209956
申请日：2011-08-15
Applicant: Lawrence L. Kunz , Peter G. Anderson
Inventor： Lawrence L. Kunz , Peter G. Anderson
IPC: A61K9/14 , A61P7/00 , A61P9/08 , A61K31/337
CPC classification number: A61K31/04 , A61K9/0024 , A61K31/00 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/50 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6923 , A61K47/6927 , A61K47/6957 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/604 , A61L2300/606 , B82Y5/00 , G01N2800/323 , Y10S977/775 , Y10S977/808 , Y10S977/905 , Y10S977/906 , Y10S977/916
Abstract: Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
Abstract translation: 提供了用于在哺乳动物宿主中的血管创伤或疾病之后抑制狭窄的方法，包括向宿主施用治疗有效剂量的含有血管平滑肌结合蛋白的治疗性缀合物，其以特定方式与血管平滑的细胞表面相关联 肌肉细胞，与抑制肌肉细胞的细胞活性的治疗剂剂型偶联。 还提供了用于通过抑制平滑肌细胞收缩导致血管腔的扩张和固定的血管平滑肌细胞的治疗剂的直接和/或靶向递送的方法，从而构成生物支架。
-
公开(公告)号：US07803531B2
公开(公告)日：2010-09-28
申请号：US10342119
申请日：2003-01-13
Applicant: Chandler Fulton , Elaine Y. Lai
Inventor： Chandler Fulton , Elaine Y. Lai
IPC: C12Q1/68 , A01N43/04 , A01N63/00 , A01N25/00 , C12N9/00 , C12N5/00 , C07H21/04 , C12N1/20 , C12N15/00 , C12Q1/00
CPC classification number: C12N9/1085 , A61K38/45 , A61K38/50 , A61K48/00 , C07K14/4747 , C07K2319/00 , C12N9/78 , C12Y205/01002 , C12Y305/99002 , Y10S977/70 , Y10S977/902 , Y10S977/905 , Y10S977/911 , Y10S977/912
Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
Abstract translation: 本公开描述了通过降低细胞中硫胺素的水平来诱导体内选择的一组脊椎动物细胞的凋亡的方法。 包括诱导癌细胞凋亡的方法。 还描述了用于硫胺消耗和治疗疾病如癌症的方法的化合物和组合物，以及鉴定硫胺消耗剂和制备药物组合物的方法。
-
公开(公告)号：US20100010440A1
公开(公告)日：2010-01-14
申请号：US12563780
申请日：2009-09-21
Applicant: Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, JR. , Jan Weber
Inventor： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, JR. , Jan Weber
IPC: A61M25/10
CPC classification number: A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
Abstract: The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
Abstract translation: 本发明提供包含纳米复合材料的医疗装置。 通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。 还提供了制造本发明的医疗装置的方法。 由于本发明的装置预期在其使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。
-
-
-
-
-
-
-
-
-
Search Results
160
records
(took 0.047 seconds)
