摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
The present invention provides a crystal suitable for X-ray diffraction, comprising a complex of insulin-like growth factor I or II (IGF) and a polypeptide consisting of the amino acids 40-92 of IGFBP-5 or a fragment thereof consisting at least of the 9th to 12th cysteine of IGFBP-5 methods for the determination of the atomic coordinates of such a crystal; IGFBP mutants with enhanced binding affinity for IGF-I and/or IGF-II, and methods to identify and optimize small molecules which displace IGFs from their binding proteins.
摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
An electrical power distribution device such as a junction box or the like includes a status indicator that also serves not only to indicate the status of energization of a connector mounted in a first housing opening, but also to illuminate a translucent indicia-bearing plate mounted in second housing opening. The housing contains a chamber in which are mounted a light emitting diode that is energized simultaneously with the connector, and a light transmitting member that directs the light produced by the LED toward the second housing opening.
摘要:
The invention relates to a method and a device for evacuating hot raw gases which occur in the oven chambers of a coke oven battery during coking. The oven gases are lead from the oven chambers into a hot gas collector. The pressure in the oven chambers is controlled by shut-off and throttling devices which are arranged in the hot gas streams between the raw gas outlet of the oven chambers and the hot gas collector. The positions of the devices are controlled according to the pressure that is measured in the allocated oven chamber. The gas of the hot gas collector is supplied to a steam boiler firing or a fission reactor.
摘要:
A conjugate consisting of insulin-like growth factor binding protein 4 (IGFBP-4) and one or two polyethylene glycol) group(s), said polyethylene glycol) group(s) having an overall molecular weight of from about 30 to about 40 kDa is disclosed. This conjugate is useful for the treatment of cancer.
摘要:
The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide.
摘要:
A heating flue for a coke oven includes a wedge-shaped refractory brick having at least one oblique surface and vertical cylindrical bores when the brick is inserted into the vertical portion of a duct at the bottom of the heating flue. This part of the duct has an increased diameter to support the brick so that the vertical sides abut the inner duct walls and the bottom oblique surface extends toward the mouth of an obliquely-rising portion of the duct. The sum of the cross-sectional areas of the cylindrical bores in the brick is from 0.75 to 1.5 times the flow cross section of the obliquely-rising duct portion. The cross-sectional area of the top of a wedge-shaped brick which is coplanar with the flue base is in a range of between 20 and 200 with the cross section of the cylindrical bore in the brick. The diameter of the bore is between 10 and 60 millimeters. A ratio of 0.3 to 1.5 is formed between an acute angle between the oblique bottom surface and the horizontal and an angle between the obliquely-rising duct portion and the horizontal. The top surface of the brick may also be oblique and parallel with the bottom surface whereby the brick has the shape of a rhomboid.