公开(公告)号：US20020020688A1

公开(公告)日：2002-02-21

申请号：US09956520

申请日：2001-09-19

Applicant: The Procter & Gamble Company

Inventor： Faiz Feisal Sherman ,  Vadim Vladimirovich Yuzhakov ,  Vladimir Gartstein ,  Grover David Owens

IPC: C23F001/00 ,  B29C069/00

CPC classification number: B29C51/082 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B29C33/0033 ,  B29C33/42 ,  B29C37/0053 ,  B29C45/2628 ,  B29C51/00 ,  B29C2059/023 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/036

Abstract: One embodiment of a microneedle array is constructed of silicon and silicon dioxide compounds using MEMS technology and standard microfabrication techniques to create hollow cylindrical individual microneedles. The resulting array of microneedles is designed to penetrate the stratum corneum and epidermis layers of skin, but not into the dermis. In a second embodiment, an array of hollow (or solid) microneedles are constructed of molded plastic, in which a micro-machining technique is used to fabricate the molds used in a plastic microforming process. Such molds contain a micropillar array and/or microhole array. The manufacturing procedures for creating plastic arrays of microneedles include: nullself-molding,null micromolding, microembossing, and microinjection techniques. In the nullself-moldingnull method, a plastic (e.g., polymer) film is placed on a micropillar array, the plastic is then heated, and plastic deformation due to gravitational force causes the plastic film to deform and create the microneedle structure. Using this procedure, only a single mold-half is required. When using the micromolding technique, a similar micropillar array is used along with a second mold-half, which is then closed over the plastic film to form the microneedle structure. The micro-embossing method uses a single mold-half that contains an array of micropillars and conical cut-outs (microholes) which is pressed against a flat surface (which essentially acts as the second mold-half) upon which the plastic film is initially placed. In the microinjection method, a molten plastic substance is injected between two micro-machined molds that contain microhole and micropillar arrays.

Abstract translation: 微针阵列的一个实施例由使用MEMS技术和标准微细加工技术的硅和二氧化硅化合物构成以产生中空圆柱形单独的微针。 所得的微针阵列被设计成穿透皮肤角质层和表皮层，但不能穿入真皮层。 在第二实施例中，空心（或固体）微针阵列由模制塑料构成，其中使用微加工技术来制造用于塑料微成型工艺中的模具。 这种模具包含微柱阵列和/或微孔阵列。 用于制造微针的塑料阵列的制造方法包括：“自成型”，微胶印，微压印和显微注射技术。 在“自成型”方法中，将塑料（例如，聚合物）膜放置在微柱阵列上，然后加热塑料，并且由于重力引起的塑性变形导致塑料膜变形并产生微针结构。 使用此程序，只需要一个半模。 当使用微型成型技术时，类似的微柱阵列与第二半模一起使用，然后将其封闭在塑料膜上以形成微针结构。 微压花方法使用单个半模，其包含微柱和圆锥形切口阵列（微孔），其被压靠在最初的塑料膜上的平坦表面（其基本上作为第二半模）上 放置 在显微注射方法中，将熔融塑料物质注入包含微孔和微柱阵列的两个微加工模具之间。

公开(公告)号：US06312612B1

公开(公告)日：2001-11-06

申请号：US09328946

申请日：1999-06-09

Applicant: Faiz Feisal Sherman ,  Vadim Vladimirovich Yuzhakov ,  Vladimir Gartstein ,  Grover David Owens

Inventor： Faiz Feisal Sherman ,  Vadim Vladimirovich Yuzhakov ,  Vladimir Gartstein ,  Grover David Owens

IPC: B81C100

CPC classification number: B29C51/082 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B29C33/0033 ,  B29C33/42 ,  B29C37/0053 ,  B29C45/2628 ,  B29C51/00 ,  B29C2059/023 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/036

Abstract: A microneedle array is constructed of silicon and silicon dioxide compounds using MEMS (i.e., Micro-Electro-Mechanical-Systems) technology and standard microfabrication techniques. The microneedle array may be fabricated from a silicon die which can be etched in a microfabrication process to create hollow cylindrical individual microneedles. The resulting array of microneedles can penetrate with a small pressure through the stratum corneum of skin (including skin of animals, reptiles, or other creatures—typically skin of a living organism) to either deliver drugs or to facilitate interstitial fluid sampling through the hollow microneedles.

Abstract translation: 微针阵列由使用MEMS（即微机电系统）技术和标准微细加工技术的硅和二氧化硅化合物构成。 微针阵列可以由可以在微细加工过程中蚀刻以形成中空圆柱形单个微针的硅晶片制造。 所产生的微针阵列可以通过皮肤角质层（包括动物，爬行动物或其他生物的皮肤，通常是生物体的皮肤）以较小的压力穿透，以递送药物或促进通过空心微针进行间质液取样 。

公开(公告)号：US5853446A

公开(公告)日：1998-12-29

申请号：US820206

申请日：1997-03-18

Applicant: Alain R.E. Carre ,  Bernard Eid ,  Mark S. Friske ,  Ronald E. Johnson ,  Candace J. Quinn ,  Frances M. Smith ,  Jean-Pierre Themont

Inventor： Alain R.E. Carre ,  Bernard Eid ,  Mark S. Friske ,  Ronald E. Johnson ,  Candace J. Quinn ,  Frances M. Smith ,  Jean-Pierre Themont

IPC: B81C1/00 ,  C03C17/04 ,  C03B21/00 ,  C03B19/01 ,  C03B19/09 ,  C03B23/00

CPC classification number: B81C1/00111 ,  C03C17/04 ,  B81C2201/036 ,  H01J2211/36

Abstract: A method and apparatus for making formed glass structures. A glass frit containing material is deposited within a recessed pattern, hardened in the recessed pattern, and transferred to a substrate. The method and apparatus of the invention are particularly useful for forming barrier rib structures for use in plasma display panels.

Abstract translation: 制造成形玻璃结构的方法和装置。 含有玻璃料的材料沉积在凹陷图案中，以凹陷图案硬化并转移到基底。 本发明的方法和装置特别适用于形成用于等离子体显示面板的隔壁结构。