公开(公告)号：US20160061925A1

公开(公告)日：2016-03-03

申请号：US14840003

申请日：2015-08-30

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/58 ,  G01R33/48 ,  G01R33/50

CPC classification number: G01R33/58 ,  G01R33/50

Abstract: A method for automatic determination of optimal Magnetic Resonance Imaging (MRI) acquisition parameters for imaging in an MRI instrument a sample containing two types of tissue, tissue A and tissue B, wherein said method comprises: determining T1A, T2A, T1B, T2B, ρA, and ρB, where ρ represents the density of NMR-active nuclei being probed; setting initial values of TR and TE; determining the signal intensities SA and SB from the equation S=ρE1E2, where E1=1−e−TR/T1 and E2=e−TE/T2; calculating the contrast-to-noise ratio for tissue A in the presence of tissue B (CNRAB) from the equation CNR AB = P  ( S A - S B ) T R , where P is a proportionality constant; and, determining optimal values of TR and TE that yield a maximum value of CNRAB(TR,TE). In other embodiments of the invention, the method includes optimization of additional acquisition parameters. An MRI system in which the method is implemented so that acquisition parameters can be optimized without any intervention by the system operator is also disclosed.

Abstract translation: 一种用于自动确定最佳磁共振成像（MRI）获取参数的方法，用于在MRI仪器中成像含有两种类型的组织，组织A和组织B的样品，其中所述方法包括：确定T1A，T2A，T1B，T2B，＆rgr ; A和＆rgr; B，其中＆rgr; 表示被探测的核磁共振活性核的密度; 设定TR和TE的初始值; 从等式S =＆rgr; E1E2确定信号强度SA和SB，其中E1 = 1-e-TR / T1和E2 = e-TE / T2; 在组织B（CNRAB）的存在下，从方程式CNR AB = P（S A-S B）T R计算组织A的对比度信噪比，其中P是比例常数; 并且确定产生CNRAB（TR，TE）的最大值的TR和TE的最佳值。 在本发明的其它实施例中，该方法包括优化额外的采集参数。 还公开了一种MRI系统，其中实施该方法使得获取参数可以在没有系统操作者的任何干预的情况下被优化。

公开(公告)号：US09272107B2

公开(公告)日：2016-03-01

申请号：US14537266

申请日：2014-11-10

Applicant: ASPECT IMAGING LTD.

Inventor： Uri Rapoport

IPC: A61M16/01 ,  A61D7/04 ,  A01K1/03 ,  A01K1/00

CPC classification number: A61M16/01 ,  A01K1/00 ,  A01K1/03 ,  A61D7/04 ,  A61M2250/00

Abstract: The present invention provides a chamber having at least one operator hand access port; the port comprising a port aperture located within the chamber wall; and at least two flexible non-resilient lightweight sealing gas-tight flaps(SFs), disposed the same plane of the port aperture in an overlapping manner, entirely enclosing the port aperture; each of the SFs is defined by a port aperture edge and chamber edges; the chamber edges are anchored to the chamber wall along more than half of the perimeter of the flap, at a distance from the center of the port greater than the radius of the port and beyond its perimeter; the port aperture edge of each flap is stretched across an entire chord of the port aperture; stretched port apertures edges define an interior access zone, disposed the same plane of the port aperture, characterized solely by the port aperture edges.

Abstract translation: 本发明提供一种具有至少一个操作者手入口的腔室; 所述端口包括位于所述室壁内的端口孔; 和至少两个柔性非弹性的轻质密封气密翼片（SF），其以重叠的方式设置在端口孔的同一平面上，完全包围端口孔; 每个SF由端口孔边缘和腔室边缘限定; 腔室边缘沿着瓣的周边的一半以上锚定到腔室壁，距离端口的中心一定距离大于端口的半径并超出其周边; 每个翼片的孔口边缘在端口孔的整个弦上被拉伸; 拉伸端口孔边缘限定内部进入区域，其设置在端口孔的相同平面上，其特征仅在于孔口边缘。

公开(公告)号：US20150335261A1

公开(公告)日：2015-11-26

申请号：US14709512

申请日：2015-05-12

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: A61B5/055 ,  A61B5/00 ,  G01R33/3815 ,  G01R33/30 ,  G01R33/383

CPC classification number: A61B5/055 ,  A61B5/4255 ,  G01R33/307 ,  G01R33/3802 ,  G01R33/3806 ,  G01R33/3815 ,  G01R33/383

Abstract: Devices and methods for providing an adjustable open-bore magnetic resonance device (MRD) that enable personalized accommodation for users of different sizes. The MRD includes a first main magnetic source and a second main magnetic source in a face-to-face orientation. The magnetic sources are separated by a distance that is adjustable by way of an endoskeletal height adjuster. In some embodiments, a superconducting electromagnet coiled around an oval defines the magnetic volume of interest. In such embodiments, the perimeter of the oval includes a plurality of trapezoid elements housing the coil of the electromagnet, and the trapezoid elements can be moved outwards and inwards relative to the oval's center in the plane of the oval.

Abstract translation: 用于提供可调节的开孔磁共振装置（MRD）的装置和方法，其能够为不同尺寸的用户提供个性化的住宿。 MRD包括面对面取向的第一主磁源和第二主磁源。 磁源分开一段可通过内骨骼高度调节器调节的距离。 在一些实施例中，缠绕在椭圆圈上的超导电磁体限定感兴趣的磁体积。 在这种实施例中，椭圆的周边包括容纳电磁体的线圈的多个梯形元件，并且梯形元​​件可以相对于椭圆的平面中的椭圆的中心向外和向内移动。

公开(公告)号：US09150364B2

公开(公告)日：2015-10-06

申请号：US14514739

申请日：2014-10-15

Applicant: ASPECT IMAGING LTD

Inventor： Uri Rapoport ,  Itzchak Rabinovitz

IPC: G06F7/00 ,  B65G51/08 ,  B65G53/66 ,  B65G51/36 ,  B60P1/60 ,  B65G51/26 ,  B65G51/22 ,  G01R33/30 ,  B65G51/28

CPC classification number: B65G51/26 ,  B65G51/22 ,  B65G51/28 ,  G01R33/307

Abstract: A pneumatic sample feedway that is embeddable into a magnetic resonance imaging (MRI) device. The feedway includes: a plurality of capsules enclosing a biological tissue sample; and a conductor pipe connected to a source of a compressed fluid. The pipe receives a train of the capsules and pneumatically forwards the train into the MRI device. The pipe has a proximal terminal that loads the train of capsules into the pipe.

Abstract translation: 可嵌入磁共振成像（MRI）装置的气动样品供给路径。 供给路径包括：包围生物组织样本的多个胶囊; 以及连接到压缩流体源的导体管。 管道接收一列胶囊并将火车气动地前进到MRI装置中。 管道具有近端端子，该近端将胶囊串装载到管道中。

公开(公告)号：US20150253400A1

公开(公告)日：2015-09-10

申请号：US14623039

申请日：2015-02-16

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/38

CPC classification number: G01R33/3804 ,  G01R33/422 ,  Y10T29/49826

Abstract: A thermo-isolating jacket for a magnetic resonance device (MRD). The thermo-isolating jacket is configured to be positioned in an atmospheric pressure, temperature changing environment. The thermo-isolating jacket provides a passive temperature insulating device to be placed on the outer side of the MRD. The thermo-isolating jacket insulates the MRD from external environment temperature fluctuations during its operation.

Abstract translation: 用于磁共振装置（MRD）的热隔离套管。 热隔离套管构造成位于大气压，变温环境中。 热隔离套管提供被放置在MRD外侧的被动温度绝缘装置。 热隔离套管在操作期间将MRD与外部环境温度波动隔离。

公开(公告)号：US20150147746A1

公开(公告)日：2015-05-28

申请号：US14090298

申请日：2013-11-26

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT ,  Camilla CAVALLOTTI ,  Simonetta GENINATTI CRICH

IPC: G01N27/74

CPC classification number: G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

Abstract: A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

Abstract translation: 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

公开(公告)号：US20150123657A1

公开(公告)日：2015-05-07

申请号：US14070695

申请日：2013-11-04

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/54

CPC classification number: G01R33/543

Abstract: A method of operating a magnetic resonance imaging (MRI) device for habituating a patient and/or user to acoustic-noise of the device's operation. The method includes: listing a required set of the pulse-sequences (RSPS) for the patient, modifying the RSPS to a new set of sequences (NSPS) further comprising at least one demo-sequence, and operating, by means of generating the pulse-sequences, according to the NSPS. The demo-sequence is a redundant sequence, used solely for acoustic-sound habituation, while the originally listed RSPS are used for medical readings, thereby habituating the patient and/or user to the acoustic-noise of the operation.

Abstract translation: 一种操作磁共振成像（MRI）装置的方法，用于将患者和/或使用者习惯于装置操作的声学噪声。 该方法包括：列出用于患者的所需脉冲序列集合（RSPS），将RSPS修改为还包括至少一个演示序列的新的序列集（NSPS），并且通过产生脉冲 根据NSPS。 演示序列是冗余序列，仅用于声音习惯，而原始列出的RSPS用于医疗读数，从而使患者和/或用户习惯于操作的声学噪声。

公开(公告)号：US20140230850A1

公开(公告)日：2014-08-21

申请号：US13906833

申请日：2013-05-31

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: A61B19/00

CPC classification number: A61B90/70 ,  A61B5/055 ,  A61B6/4423 ,  G01R33/28

Abstract: A ramrod for cleaning the bore of an MRI device, including: a head with a cross-section substantially identical in shape to the MRI bore's cross-section, the cross section having size slightly smaller than the MRI's bore's cross-section to fit snugly and movably within the bore, the head having at least one end, the head having a longitudinal axis; and a rigid extended longitudinal body rigidly connected to the at least one end, the body having a longitudinal axis. The passage of the ramrod through the bore removes particulates from the bore.

Abstract translation: 用于清洁MRI装置的孔的冲头，包括：具有与MRI孔的横截面基本相同的横截面的头部，横截面的尺寸略小于MRI的孔的横截面以适应贴合和 可移动地在孔内，头部具有至少一个端部，头部具有纵向轴线; 以及刚性地连接到所述至少一个端部的刚性延伸的纵向主体，所述主体具有纵向轴线。 柱塞通过孔的通道从孔中去除微粒。

公开(公告)号：US20140225611A1

公开(公告)日：2014-08-14

申请号：US14178882

申请日：2014-02-12

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/30 ,  G01R33/56

CPC classification number: G01R33/30 ,  G01R33/302 ,  G01R33/3802 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/3815 ,  G01R33/383 ,  G01R33/465 ,  G01R33/5601

Abstract: A system for MRI imaging the near surface of tissue specimens wherein the volume of interest of the MRI is held substantially within the surface-proximate tissue of the specimen by means of some combination of maneuvering the specimen, maneuvering the MRI RF magnetic field magnet, maneuvering the MRI RF receiver coil, maneuvering the static field magnets, and reshaping the tissue.

Abstract translation: 用于对组织样本的近表面进行MRI成像的系统，其中MRI的感兴趣的体积通过操纵样本，操纵MRI RF磁场磁体的某种组合基本上保持在样本的表面附近组织内，机动 MRI射频接收器线圈，操纵静态磁体，并重塑组织。

公开(公告)号：US20140158062A1

公开(公告)日：2014-06-12

申请号：US14182766

申请日：2014-02-18

Applicant: Aspect Imaging Ltd.

Inventor： Uri Rapoport ,  Itzchak Rabinovitz

IPC: A01K29/00 ,  A61B5/055

CPC classification number: A61B5/0555 ,  A01K29/005 ,  G01R33/30

Abstract: An animal handling system for use in an MRD device, including: a first elongated enclosure having a proximal end, a distal open end and a first geometry, and a second first elongated enclosure having a proximal end, a distal open end and a second geometry. The first second geometry comprises a first cross-sectional area which is larger than a second cross-sectional area of the second geometry. The first elongated enclosure is inserted into a first input port of the MRD device and the second elongated enclosure is inserted in a second input port of the MRD device diametrically opposite to second input port, such that on insertion of the first elongated enclosure into the first input port and insertion of the second elongated enclosure into the second input, the second elongated enclosure slides into the first elongated enclosure through the open distal end of the first elongated enclosure.

Abstract translation: 一种用于MRD装置的动物处理系统，包括：具有近端，远端开口端和第一几何形状的第一细长外壳，以及具有近端，远端开口端和第二几何形状的第二第一细长外壳 。 第一第二几何形状包括大于第二几何形状的第二横截面积的第一横截面面积。 所述第一细长外壳被插入到所述MRD装置的第一输入端口中，并且所述第二细长外壳插入到所述MRD装置的与所述第二输入端口径向相对的第二输入端口中，使得在将所述第一细长外壳插入所述第一细长外壳 输入端口和将第二细长外壳插入第二输入端，第二细长外壳通过第一细长外壳的敞开的远端滑入第一细长外壳。