公开(公告)号：US10939999B2

公开(公告)日：2021-03-09

申请号：US16025977

申请日：2018-07-02

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jose L. Navia ,  Ji-Feng Chen ,  Shengqiang Gao ,  Brian L. Davis ,  Samantha Stucke

IPC: A61F2/24

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

公开(公告)号：US10890639B2

公开(公告)日：2021-01-12

申请号：US16413896

申请日：2019-05-16

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: G01V3/00 ,  G01R33/48 ,  C12Q1/6876 ,  A61B5/055 ,  A61B5/00

Abstract: Systems and methods are provided for correlating functional magnetic resonance imaging (fMRI) with gene expression. Brains of first and second sets of patients are imaged at first and second times to provide first and second sets of fMRI images. Blood is drawn from each of the first and second sets of patients at the first and second times to provide first and second sets of gene expression transcripts. A therapeutic is administered to the first set of patients between the first and second times. A change in the connectivity of the brain for each patient is determined from the first and second sets of fMRI images. A set of changes in the peripheral lymphocyte gene expression that are correlated with changes in the connectivity of the brain are determined from the change in the connectivity of the brain for each patient and the collected imaging and gene expression data.

公开(公告)号：USD903982S1

公开(公告)日：2020-12-08

申请号：US29627881

申请日：2017-11-30

Applicant: THE CLEVELAND CLINIC FOUNDATION

Designer： Jill Elizabeth Byrne

公开(公告)号：US10849708B2

公开(公告)日：2020-12-01

申请号：US14564309

申请日：2014-12-09

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jianguo Cheng

IPC: A61B90/11 ,  A61B18/00 ,  A61B17/34 ,  A61B18/14 ,  A61B90/00

Abstract: Device and methods for treating conditions caused by or associated with a sacroiliac joint abnormality using radiofrequency ablation. A surgical jig is provided that facilitates safe, easy, and quick placement of electrodes in a patient's spinal region for radiofrequency ablation of a set of spinal nerves and/or sacroiliac ligaments.

公开(公告)号：US20200367927A1

公开(公告)日：2020-11-26

申请号：US16650938

申请日：2018-09-26

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karunakaravel Karuppasamy

IPC: A61B17/34 ,  A61M25/09 ,  A61M29/00 ,  A61M25/00

Abstract: An introducer sheath is provided for inserting at least one medical instrument directly toward a target patient tissue site. A plurality of lumens extend longitudinally between sheath proximal and distal ends of the introducer sheath. A septum extends between the sheath proximal and distal ends and selectively laterally separates each of the sheath lumens from one another. The septum is at least partially formed from a deformable and elastomeric material. The septum has a biased condition in which the plurality of sheath lumens are at least partially isolated from one another. The septum is selectively deflectable from the biased condition to at least partially place at least one of the plurality of sheath lumens in fluid communication with at least one other of the plurality of sheath lumens.

公开(公告)号：US10820948B2

公开(公告)日：2020-11-03

申请号：US16593374

申请日：2019-10-04

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karl West ,  Jeffrey H. Yanof

IPC: A61B34/20 ,  A61B5/06 ,  A61B5/00 ,  G06T17/20 ,  G06T3/00 ,  G06T3/20 ,  G06F3/01 ,  G06T7/33 ,  A61B90/00 ,  G06K9/32 ,  G06K9/00 ,  A61M5/00 ,  A61B34/00 ,  A61B34/10 ,  A61B90/50 ,  G02B27/01 ,  G06T19/00

Abstract: Holographic image-guidance can be used to track an interventional device during an endovascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and vasculature image data to a common coordinate system and creating a holographic display relative to a patient's vasculature to track the interventional device during the endovascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy (e.g., the vasculature).

公开(公告)号：US10799360B2

公开(公告)日：2020-10-13

申请号：US15968000

申请日：2018-05-01

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Samir Kapadia

IPC: A61F2/24 ,  A61M29/02

Abstract: A system for treating regurgitation of blood through a diseased heart valve having at least two leaflets can include an implantable, lollipop-shaped device and an adjustment mechanism. The device can have a proximal end portion, a distal end portion, and an intermediate portion extending therebetween. The intermediate portion can include an expandable occluding member having a selectively adjustable diameter and a biocompatible layer attached to at least a portion thereof. The distal end portion can include an anchoring member. The adjustment member can include a distal connecting end that is operatively connected to the proximal end portion of the device. Operation of the adjustment member, after implantation of the device, can cause the diameter of the occluding member to change so that at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve.

公开(公告)号：US20200312461A1

公开(公告)日：2020-10-01

申请号：US16720589

申请日：2019-12-19

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Adam Bartsch ,  Sergey Samorezov

IPC: G16H50/30 ,  G06N5/04 ,  G06F30/23 ,  G16H50/20

Abstract: Methods of analyzing and assessing users that have experienced impacts may include methods of identifying or filtering false positives, methods of co-registration of sensors, algorithms for translating sensed kinematics to relevant locations, and methods of assessing users based on historical and collected impact data combined with assessment data.

公开(公告)号：US20200291093A1

公开(公告)日：2020-09-17

申请号：US16635796

申请日：2018-08-03

Applicant: The Cleveland Clinic Foundation

Inventor： Keith McCrae ,  Sergei Merkulov

IPC: C07K14/775 ,  C07K16/18 ,  C12N15/64 ,  G01N33/68 ,  G01N33/543

Abstract: Provided herein are compositions, systems, kits, and methods for expressing a peptide of interest, such as Apolipoprotein H (ApoH), also known as β2-glycoprotein I (β2GPI), at increased levels using a non-ApoH signal peptide (e.g., a signal peptide that permits increased protein export from cells). Also provided herein are compositions, systems, kits, and methods for employing such recombinant ApoH with a non-ApoH signal peptide to detect subject Apolipoprotein H antibodies in a sample from a subject (e.g., to diagnose antiphospholipid syndrome in a subject).

公开(公告)号：US20200282017A1

公开(公告)日：2020-09-10

申请号：US16807792

申请日：2020-03-03

Applicant: The Cleveland Clinic Foundation

Inventor： Eugene Chang ,  Jeanette Messer

IPC: A61K38/17 ,  C12Q1/02 ,  A61P1/00 ,  A61K47/64

Abstract: The present disclosure relates to compositions and methods for reducing virulence of microorganisms. In particular, the present invention provides HMGB1 and variants and mimetics thereof for use in reducing virulence of microorganisms (e.g., in disease).