公开(公告)号：US10939999B2

公开(公告)日：2021-03-09

申请号：US16025977

申请日：2018-07-02

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jose L. Navia ,  Ji-Feng Chen ,  Shengqiang Gao ,  Brian L. Davis ,  Samantha Stucke

IPC: A61F2/24

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

公开(公告)号：US20190008632A1

公开(公告)日：2019-01-10

申请号：US16025977

申请日：2018-07-02

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jose L. Navia ,  Ji-Feng Chen ,  Shengqiang Gao ,  Brian L. Davis ,  Samantha Stucke

IPC: A61F2/24

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

公开(公告)号：US20140214156A1

公开(公告)日：2014-07-31

申请号：US14230216

申请日：2014-03-31

Applicant: The Cleveland Clinic Foundation

Inventor： Jose L. Navia ,  Ji-Feng Chen ,  Shengqiang Gao ,  Brian L. Davis ,  Samantha Stucke

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

Abstract translation: 用于更换患病心脏瓣膜的装置可从径向收缩的构型移动到径向扩张的构型。 该装置包括可扩张的支撑构件和固定在其中的假体阀。 主体部分在第一和第二端部之间延伸并且包括外圆周表面，围绕圆周表面延伸的周向轴线以及通过可扩张区域彼此间隔开的多个翼构件。 每个翼构件包括第一和第二端部以及在端部之间延伸的柔性中间部分。 第二端部与U形体主体部一体地形成。 第一端部部分与周向轴线相邻并且在径向折叠构造中基本上与外圆周表面齐平。 第一端部部分在径向膨胀的构造中基本上径向延伸到外周表面。

公开(公告)号：US10010416B2

公开(公告)日：2018-07-03

申请号：US14230216

申请日：2014-03-31

Applicant: The Cleveland Clinic Foundation

Inventor： Jose L. Navia ,  Ji-Feng Chen ,  Shengqiang Gao ,  Brian L. Davis ,  Samantha Stucke

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

公开(公告)号：US20130060227A1

公开(公告)日：2013-03-07

申请号：US13667118

申请日：2012-11-02

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Rishi P. Singh ,  Vadim F. Lvovich ,  Brian L. Davis

IPC: A61M37/00

CPC classification number: A61N1/303 ,  A61B17/0231 ,  A61F9/0017 ,  A61N1/325

Abstract: A method is provided for delivering at least one therapeutic agent to an ocular tissue of a subject. The method includes providing an apparatus including at least one electrode, a medicament layer including at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed first and second dome-shaped major surfaces. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source is electrically connected to the at least one electrode. At least one portion of the first major surface is placed into contact with the ocular tissue so that the at least one portion substantially conforms to the contour of the ocular tissue. The electrical signal source provides a signal having certain characteristics to motivate the at least one therapeutic agent into the ocular tissue.

Abstract translation: 提供了一种将至少一种治疗剂递送到受试者的眼组织的方法。 该方法包括提供包括至少一个电极，包括至少一个治疗剂的药物层，电信号源和被配置为控制电信号源的逻辑的装置。 至少一个电极具有相对设置的第一和第二圆顶形主表面。 药物层设置在第二主表面的至少一部分上。 电信号源电连接到至少一个电极。 将第一主表面的至少一部分放置成与眼组织接触，使得至少一个部分基本上符合眼组织的轮廓。 电信号源提供具有某些特征的信号以激励至少一种治疗剂进入眼组织。