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    Apparatus and Method for Automated Quality Control
    61.
    发明申请
    Apparatus and Method for Automated Quality Control 有权
    自动质量控制的装置和方法

    公开(公告)号：US20100145630A1

    公开(公告)日：2010-06-10

    申请号：US12630298

    申请日：2009-12-03

    Applicant: Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Jianzhong Zhang

    Inventor： Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Jianzhong Zhang

    IPC: G06F19/00

    CPC classification number: G01N35/00663 ,  G01N15/06 ,  G01N2030/8804 ,  G01N2033/0093

    Abstract: Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating.

    Abstract translation: 评估用于成像放射性化合物释放的当前质量控制方法和装置，例如作为注射剂的PET示踪剂，以自动方式，无需用户干扰，并符合法规。 本方法和系统涉及使用单个样品注入用于多个在线质量控制测试的物质的综合自动化质量控制分析。 通过多次质量控制测试对样品进行定量分析。 确定多个质量控制参数中的每一个的测量值，并且进行多个质量控制参数的每个测量值与预定的对应标准值的比较。 确定样品的累积质量等级，并根据质量评级释放验证的样品。

    Apparatus and Method Using Rotary Flow Distribution Mechanisms
    62.
    发明申请
    Apparatus and Method Using Rotary Flow Distribution Mechanisms 失效
    使用旋转流量分布机制的装置和方法

    公开(公告)号：US20100113762A1

    公开(公告)日：2010-05-06

    申请号：US12612091

    申请日：2009-11-04

    Applicant: Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Jianzhong Zhang

    Inventor： Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Jianzhong Zhang

    IPC: B01J8/10 ,  G21C1/01 ,  C07C229/34 ,  C07D473/18 ,  C07D471/10 ,  C07H19/06 ,  C07D401/02 ,  C07C255/04 ,  C07D231/54

    CPC classification number: B01J19/0093 ,  B01L3/567

    Abstract: Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.

    Abstract translation: 提出了用于促进批量装置中化合物合成的方法和装置。 描述了批间型微流体装置在放射性标记化合物的合成中的应用。 这些方法和装置使得能够通过增强型旋流分配阀通过合成装置的单个入口选择性地引入多种试剂。 通过单个入口端口连续引入多种试剂允许将高度浓缩的试剂最佳递送到反应器中并促进所需产物的合成，并且在转移过程中材料损失最小，这对于放射性标记的生物标志物的合成至关重要。

    NONFLOW-THROUGH APPRATUS AND MEHOD USING ENHANCED FLOW MECHANISMS
    63.
    发明申请
    NONFLOW-THROUGH APPRATUS AND MEHOD USING ENHANCED FLOW MECHANISMS 审中-公开
    使用增强流动机制的非流动装置和手段

    公开(公告)号：US20100093098A1

    公开(公告)日：2010-04-15

    申请号：US12578175

    申请日：2009-10-13

    Applicant: Carroll Edward Ball ,  Arkadij Elizarov ,  Hartmuth C. Kolb

    Inventor： Carroll Edward Ball ,  Arkadij Elizarov ,  Hartmuth C. Kolb

    IPC: G01N1/40 ,  B01D1/00 ,  B01D1/16 ,  G01N35/08 ,  G05D7/00 ,  G05D16/00 ,  G05D23/00 ,  G05D27/00

    CPC classification number: B01J19/0093 ,  B01F5/0057 ,  B01F5/0068 ,  B01F13/0059 ,  B01J2219/00788 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  C07B59/00 ,  Y10T436/115831

    Abstract: Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor.

    Abstract translation: 提出了促进非通流装置中化合物合成的方法和装置。 描述了将非流通方法和微流体装置应用于放射性标记化合物的合成。 这些方法和装置能够通过切向狭缝将加压气体引入非流通装置的涡流反应器中，同时一个或多个液体通过相同或不同的入口输送到反应室。 加压气体的引入在反应器内产生混合物的旋风运动。 这种机理可以用于促进在较低温度下反应器内的各种液体的蒸发，从而减少与使用高温相关的不需要的副产物的产生。 此外，可以快速实施各种液体的充分混合，同时允许在涡流反应器内有效地发生化学反应。

    Sulfonyl linker for the creation of libraries via immobilization of amines
    69.
    发明授权
    Sulfonyl linker for the creation of libraries via immobilization of amines 失效
    用于通过胺固定产生文库的磺酰基接头

    公开(公告)号：US06451918B1

    公开(公告)日：2002-09-17

    申请号：US09533287

    申请日：2000-03-22

    Applicant: Hartmuth C. Kolb ,  Gerard McGeehan

    Inventor： Hartmuth C. Kolb ,  Gerard McGeehan

    IPC: C08F27300

    CPC classification number: C08F8/30

    Abstract: Disclosed are novel compounds of which function as a sulfonyl linker between a target molecule and a polymer solid support, novel sulfonyl aziridine scaffold intermediates to optimize the regioselectivity associated with the nucleophilic substitution of these aziridines, a method for making derivatized aziridine, and a method for making derivatized amines.

    Abstract translation: 公开了其作为靶分子和聚合物固体载体之间的磺酰接头的新化合物，用于优化与这些氮丙啶的亲核取代相关的区域选择性的新型磺酰基氮丙啶支架中间体，制备衍生化的氮杂环丁烷的方法，以及用于 制成衍生胺。

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