公开(公告)号：US20030165853A1

公开(公告)日：2003-09-04

申请号：US10005996

申请日：2001-12-03

Applicant: The Regents of the University of California Office of Technology Transfer

Inventor： William M. Partridge ,  Ruben J. Boado

IPC: A61K051/00 ,  C12Q001/68

CPC classification number: C12Q1/6816 ,  A61K47/64 ,  C12Q1/68 ,  G01N33/5308 ,  C12Q2543/10 ,  C12Q2563/131 ,  C12Q2525/107

Abstract: This invention provides imaging reagents for the detection of a gene or gene expression product (e.g. mRNA) in a brain cell in vivo. Preferred reagents comprise a detectable label attached to a first nucleic acid that specifically hybridizes to the gene or to a nucleic acid transcribed from the gene. The first nucleic acid is linked to a targeting ligand that is capable of binding a receptor on a cell comprising the blood brain barrier and crossing said blood brain barrier.

Abstract translation: 本发明提供用于在体内检测脑细胞中的基因或基因表达产物（例如mRNA）的成像试剂。 优选的试剂包含连接到与该基因或与该基因转录的核酸特异性杂交的第一核酸的可检测标记。 第一核酸与能够结合包含血脑屏障的细胞上的受体并穿过所述血脑屏障的靶向配体连接。

公开(公告)号：US20030106160A1

公开(公告)日：2003-06-12

申请号：US10037785

申请日：2001-10-22

Applicant: University of CA, Office of Technology Transfer University of CA Office of the President

Inventor： Gang Sun ,  Dapeng Li

IPC: D06M010/00

CPC classification number: D06P1/0016 ,  C09B67/0097 ,  D06M11/42 ,  D06M11/44 ,  D06M11/49 ,  D06M11/74 ,  D06M11/79 ,  D06M11/83 ,  D06P1/44 ,  Y10S8/918 ,  Y10S8/922 ,  Y10S8/924 ,  Y10S8/927

Abstract: The present invention employs the use of nanotechnology to textile coloration. The textiles so produced have good fastness and greatly reduce environmental concerns. The present invention provides nanoparticle processed textiles, formulations and methods for producing them.

Abstract translation: 本发明利用纳米技术来纺织着色。 如此生产的纺织品具有良好的牢度，并大大减少了环境问题。 本发明提供纳米颗粒加工纺织品，制剂及其制备方法。

公开(公告)号：US20030091986A1

公开(公告)日：2003-05-15

申请号：US10014318

申请日：2001-11-09

Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA, Office of Technology Transfer

Inventor： Maria G. Pallavicini ,  Brian P. Mullaney

IPC: C12Q001/70 ,  C12Q001/68 ,  G01N033/53

CPC classification number: C40B40/02 ,  C12N15/1037

Abstract: The n provides method of mapping polypeptide-encoding regions of genes. In particular, the invention provides methods of identifying, isolating and mapping a genomic exon sequence at the protein level using epitope phage display libraries. The invention also provides epitope- and antibody-phage display libraries and a novel phage expression vector.

Abstract translation: n提供了绘制基因多肽编码区的方法。 特别地，本发明提供使用表位噬菌体展示文库鉴定，分离和定位蛋白质级别的基因组外显子序列的方法。 本发明还提供表位和抗体噬菌体展示文库和新颖的噬菌体表达载体。

公开(公告)号：US20030017535A1

公开(公告)日：2003-01-23

申请号：US10027400

申请日：2001-12-19

Applicant: The Regents of the University of California Office of Technology Transfer

Inventor： Lewis Thomas Williams ,  Jaime A. Escobedo

IPC: C12P021/02 ,  C12N005/06 ,  C07H021/04 ,  C12N009/24 ,  C07K014/705

CPC classification number: C07K14/71 ,  G01N33/74 ,  G01N2333/49

Abstract: DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.

公开(公告)号：US20020119115A1

公开(公告)日：2002-08-29

申请号：US10041200

申请日：2002-01-08

Applicant: Office of Technology Transfer, National Institutes of Health

Inventor： Larry K. Keefer ,  Joseph A. Hrabie

IPC: A61K048/00 ,  A61K039/395 ,  A61K031/74 ,  A61K038/00 ,  A61K031/715

CPC classification number: A61K31/655 ,  A61K31/785 ,  A61K47/56 ,  A61K47/58 ,  A61K47/59 ,  A61K47/64

Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2null functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.

Abstract translation: 能够在生理条件下释放一氧化氮的聚合物组合物，其包括结合一氧化氮释放N2O2-官能团的生物聚合物，例如肽，多肽，蛋白质，寡核苷酸或核酸; 包含聚合物组合物的药物组合物; 以及治疗用一氧化氮剂量治疗的生物学障碍的方法。