公开(公告)号：US20220175558A1

公开(公告)日：2022-06-09

申请号：US17440748

申请日：2020-03-24

Applicant: Centre National de la Recherche Scientifique ,  INSERM - Institut National de la Santé et de la Recherche Médicale ,  SORBONNE UNIVERSITÉ

Inventor： Nathanaël JARRASSÉ ,  Mathilde LEGRAND ,  Guillaume MOREL

IPC: A61F2/70 ,  B25J9/00 ,  A61F2/58 ,  A61H1/02

Abstract: The present invention concerns a device for controlling a robotic system for assisting the mobility of a user, said robotic system comprising at least one active mobility assistance element capable of assisting a given mobility action of the user, characterized in that the device comprises a detection system capable of detecting a compensatory movement of the user associated with the mobility action, said compensatory movement being a movement made by a user who is disabled, or able-bodied but locally and/or temporarily constrained, in order to perform at least part of the mobility action, and which at least partially substitutes the normal movement an unconstrained, able-bodied user would make in order to perform this mobility action, and a control system capable of controlling the at least one active element when the compensatory movement is detected.

公开(公告)号：US20210346519A1

公开(公告)日：2021-11-11

申请号：US16968196

申请日：2019-02-07

Applicant: GENETHON ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  SORBONNE UNIVERSITÉ ,  UNIVERSITE D'EVRY VAL D'ESSONNE ,  ASSOCIATION INSTITUT DE MYOLOGIE

Inventor： FEDERICO MINGOZZI ,  PASQUALINA COLELLA

IPC: A61K48/00 ,  C12N15/86

Abstract: The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivity, such as two promoters driving expression in different tissues in a tissue-selective manner.

公开(公告)号：US11135446B2

公开(公告)日：2021-10-05

申请号：US16318435

申请日：2017-08-01

Applicant: GENSIGHT BIOLOGICS ,  Sorbonne Université ,  Centre national de la recherche scientifique ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERECHE MEDICALE (INSERM)

Inventor： Joël Chavas ,  Guillaume Chenegros ,  Benjamin Benosman

IPC: A61F9/008 ,  A61N5/06 ,  G02B27/01 ,  G09B21/00 ,  A61F9/08 ,  A61N5/00

Abstract: The present invention concerns a medical device (10) intended to be worn by a human wearer, the medical device (10) defining a first area (26) and a second area (28), each area being intended to be positioned in front of a respective eye of the wearer. The medical device (10) comprises a frame (10), comprising a rear shell (34). The rear shell (34) defines a hole (54) facing the first area (26) and the rear shell (34) is opaque facing the second area (28). The medical device (10) also comprises an optical module (20) in the first area (26). The optical module (20) comprises a light source (70) and an optical system (72). The optical module (20) is arranged to send a light beam through the hole (54). The medical device (10) further comprises an electronic circuitry (18), adapted to command the optical module (20).

公开(公告)号：US20210149188A1

公开(公告)日：2021-05-20

申请号：US16622987

申请日：2018-06-28

Applicant: GENSIGHT BIOLOGICS ,  Sorbonne Université ,  Centre National de la Recherche Scientifique ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Joël CHAVAS ,  Guillaume CHENEGROS ,  Charlie GALLE

IPC: G02B27/00 ,  G02B3/14

Abstract: The present invention concerns an objective (10) for imaging an object field of view of 10° onto an imager (12), the objective (10) comprising in order of the propagating direction: —a first lens unit (U1) comprising several lenses, the first lens unit (U1) having a positive first focal length and a first dimension inferior to 15 millimeters, —a bending mirror (M) adapted to bend at a 90° angle, —a liquid lens (LL), and —a second lens unit (U2) comprising several lenses, the second lens unit (U2) having a positive second focal length and a second dimension, the ratio between the first focal length and the second focal length being comprised between 1.0 and 2.0 and the ratio between the first dimension and the second dimension being superior or equal to 2.

公开(公告)号：US20210121532A1

公开(公告)日：2021-04-29

申请号：US16965700

申请日：2019-02-18

Applicant: ILTOO PHARMA ,  ASSISTANCE PUBLIQUE - HÖPITAUX DE PARIS ,  SORBONNE UNIVERSITÉ

Inventor： David KLATZMANN ,  Roberta LORENZON ,  Michèle ROSENZWAJG ,  Patrice CACOUB ,  Arsene MEKINIAN

IPC: A61K38/20 ,  A61P37/00 ,  A61K47/60 ,  A61K47/68

Abstract: The invention relates to the use of interleukin-2 in treating Sjögren's syndrome in a subject, wherein IL-2 is to be administered at a low dose of less than about 3.5 MIU/day.

公开(公告)号：US20210085172A1

公开(公告)日：2021-03-25

申请号：US16954720

申请日：2017-12-21

Applicant: SORBONNE UNIVERSITÉ ,  ESSILOR INTERNATIONAL

Inventor： José-Alain SAHEL ,  Angelo ARLEO ,  Anne-Catherine SCHERLEN ,  Delphine TRANVOUEZ-BERNARDIN

IPC: A61B3/024 ,  A61B3/113 ,  A61B3/00

Abstract: A method of analyzing a visual field of an individual comprises the following steps:—measuring (S4) a first visual field (VF1) of said individual for a first set of oculo-postural parameters of said individual when said individual performs a first task;—measuring (S6) at least one additional visual field (VFi) of said individual for one additional set of said oculo-postural parameters of said individual when said individual performs an additional task;—determining (S8) a functional visual space based on said first visual field (VF1) and said at least one additional visual field (VFi), said functional visual space being an envelope of said first visual field and said at least one additional visual field. The additional task differs from said first task and/or said additional set of oculo-postural parameters differs from said first set of oculo-postural parameters. A corresponding ophthalmic lens is also proposed.

公开(公告)号：US20200253889A1

公开(公告)日：2020-08-13

申请号：US16652947

申请日：2018-10-04

Applicant: SORBONNE UNIVERSITÉ ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE- HÖPITAUX DE PARIS ,  KYOTO UNIVERSITY

Inventor： Dominique Gauguier ,  Fumihiko Matsuda ,  François Brial

IPC: A61K31/05 ,  A61P3/10

Abstract: The invention pertains to a compound of formula (I), one of its pharmaceutically acceptable salts, or a composition comprising thereof, for use in the prevention or treatment of glucose intolerance related conditions, insulin deficit related conditions, nonalcoholic fatty liver disease and/or obesity.

公开(公告)号：US20190323048A1

公开(公告)日：2019-10-24

申请号：US16333207

申请日：2017-09-12

Applicant: Centre National de la Recherche Scientifique ,  Sorbonne Université

Inventor： Gurvan MICHEL ,  Alexia GUILLOUZO ,  Bertille MASSÉ ,  Sabine GÉNICOT ,  Agnès GROISILLIER

IPC: C12P19/12 ,  C12N9/88

Abstract: Some embodiments are directed to a novel ulvan lyase, a nucleic acid sequence coding for said enzyme, a vector comprising said coding sequence, a method for manufacturing said ulvan lyase, and a method for producing ulvan oligosaccharides with biological activity using said enzyme

公开(公告)号：US20190312078A1

公开(公告)日：2019-10-10

申请号：US16470515

申请日：2017-12-18

Applicant: SORBONNE UNIVERSITÉ

Inventor： Mohamed Ben Chouikha ,  Gérard Dubois

IPC: H01L27/146 ,  H01L31/101

Abstract: A multi-spectral photodetector is provided, comprising: a plurality of N photodetectors where N is an integer such that N≥2, each photodetector comprising an anode and a cathode separated from one another by a region of interest, all produced in a semiconductor material; at least one electrical contact for all of the N anodes; and an electrical contact associated with each of the N cathodes; said photodetectors being stacked on top of one another such that the anodes and the cathodes and finally the regions of interest of two consecutive photodetectors in the stack are arranged face to face, this stack making it possible to define a face, termed the active face of the multi-spectral photodetector, common to all the photodetectors of the stack, defined by the face of the first region of interest of the first photodetector of the stack via which photons are intended to enter the stack.

公开(公告)号：US20190175934A1

公开(公告)日：2019-06-13

申请号：US16310490

申请日：2017-06-16

Applicant: SORBONNE UNIVERSITÉ ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  GENSIGHT BIOLOGICS

Inventor： Joël CHAVAS ,  Guillaume CHENEGROS ,  Benjamin R. BENOSMAN

IPC: A61N5/06 ,  G02B26/08 ,  G02B26/02

Abstract: The invention concerns a device 10 for illuminating an object 12 with a controlled light intensity, the light intensity being controlled when the light intensity fulfills a plurality of conditions to be fulfilled, the plurality of conditions comprising a condition relative to the intensity at a given time and a condition relative to the dose during a period of time.