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公开(公告)号：US20230120968A1
公开(公告)日：2023-04-20
申请号：US17960251
申请日：2022-10-05
Inventor： Nael Abu-Ghazaleh , Weishuai Yang , Michael Lewis
Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.
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公开(公告)号：US20230079219A1
公开(公告)日：2023-03-16
申请号：US17930738
申请日：2022-09-09
Applicant: The Trustees of the University of Pennsylvania , The Research Foundation for The State University of New York
Inventor： Thomas F. Floyd , Arjun G. Yodh , Rickson C. Mesquita
IPC: A61B5/00 , A61B5/1459 , A61B5/026 , A61B5/1455
Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.
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公开(公告)号：US20230071019A1
公开(公告)日：2023-03-09
申请号：US17782549
申请日：2020-12-04
Inventor： Joseph P. BALTHASAR , Brandon M. BORDEAU , Toan Duc NGUYEN , Joseph Ryan POLLI
Abstract: Provided are compositions and methods for reducing off-target toxicity of antibody-drug conjugates (ADCs). The compositions comprise an ADC, and an agent targeted to the drug (payload) that is delivered by or derived from the ADC. The ADC and the agent targeted to the payload may be delivered together or separately in the treatment of various conditions (such as tumors) by ADCs. Examples of agents targeted to payload include antibodies, fragments, or modifications thereof.
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公开(公告)号：US20230059151A1
公开(公告)日：2023-02-23
申请号：US17790086
申请日：2021-01-21
Inventor： Lance SNEAD , David SPROUSTER , Jason TRELEWICZ
Abstract: Composite structures are provided whose composite matrix is a fully-dense (greater than 95%) magnesium oxide-containing phase and whose entrained phase, by virtue of its' decomposition temperature or chemical reactivity, would otherwise not be fabricable. Notably, a methodology is provided whereby a range of composite structures are formed by applying an advanced manufacturing technique and a blend of ceramic powder whose sintering is enhanced by small amounts of a metal halide sintering aid. This methodology and process significantly lowers the processing temperature of refractory ceramics such as magnesium oxide allowing formation of ceramic bodies incorporating phases such as metal hydrides, fragile ceramic phases, and highly reactive species such as beryllides. In all cases, the final product is substantially-free, or even devoid, of the metal halide sintering aid, resulting in a phase-pure ceramic matrix composed of the host phase and the entrained phase.
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公开(公告)号：US20230053231A1
公开(公告)日：2023-02-16
申请号：US17681139
申请日：2022-02-25
Inventor： Stacy W. BLAIN
Abstract: Compositions and methods for the treatment of malignancy are disclosed.
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Patent Agency Ranking
公开(公告)号：US20230033523A1
公开(公告)日：2023-02-02
申请号：US17390453
申请日：2021-07-30
Inventor： Li-Ru Zhao , Suning Ping
Abstract: The present disclosure relates to a method of improving neurological function and enhancing cerebrovascular maintenance and regeneration in a mammal suffering from cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), including administering an effective amount of a composition including a granulocyte colony-stimulating factor (G-CSF) polypeptide in combination with a stem cell factor (SCF) polypeptide.
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公开(公告)号：US20230017948A1
公开(公告)日：2023-01-19
申请号：US17779214
申请日：2020-11-24
Applicant: Iwao OJIMA , Martin Martin KACZOCHA , Gregory CARBONETTI , The Research Foundation for The State University of New York
Inventor： Iwao Ojima , Martin Kaczocha , Gregory Carbonetti
IPC: A61K31/216 , A61K31/337 , A61K45/06 , A61P35/00 , C07C69/757
Abstract: This invention provides a method of treating a subject afflicted with a cancer comprising periodically administering to the subject an amount of a FABP5 inhibitor and an amount of an anticancer therapy, wherein the amounts when taken together are effective to treat the subject. This invention also provides FABP5 inhibitors for use as an add-on therapy or in combination with an anticancer therapy or in treating a subject afflicted with a cancer. This invention also provides the use of a FABP5 inhibitor in the manufacturing of a medicament for use in combination or as an add on with an anticancer therapy in treating a subject afflicted with cancer, wherein the FABP5 inhibitor and the anticancer therapy are administered simultaneously, contemporaneously or concomitantly. This invention also provides a pharmaceutical composition comprising an amount of a FABP5 inhibitor and an amount of an anticancer therapy for use in treating a subject afflicted with a cancer, wherein the FABP5 inhibitor and an anticancer therapy are administered sequentially or simultaneously.
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公开(公告)号：US11550173B2
公开(公告)日：2023-01-10
申请号：US16952013
申请日：2020-11-18
Applicant: The Research Foundation for The State University of New York , Government of the United States, as Represented by the Secretary of the Air Force , Morton Photonics Incorporated
Inventor： Douglas Coolbaugh , Douglas La Tulipe , Paul A. Morton , Nicholas G. Usechak
Abstract: There is set forth herein an integrated photonics structure having a waveguide disposed within a dielectric stack of the integrated photonics structure, wherein the integrated photonics structure further includes a field generating electrically conductive structure disposed within the dielectric stack; and a heterogenous structure attached to the integrated photonics structure, the heterogenous structure having field sensitive material that is sensitive to a field generated by the field generating electrically conductive structure. There is set forth herein a method including fabricating an integrated photonics structure, wherein the fabricating an integrated photonics structure includes fabricating a waveguide within a dielectric stack, wherein the fabricating an integrated photonics structure further includes fabricating a field generating electrically conductive structure within the dielectric stack; and attaching a heterogenous structure to the integrated photonics structure, the heterogenous structure having field sensitive material that is sensitive to a field generated by the field generating electrically conductive structure.
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公开(公告)号：US11550099B2
公开(公告)日：2023-01-10
申请号：US16575938
申请日：2019-09-19
Inventor： William Charles , Douglas Coolbaugh , Douglas La Tulipe , Gerald L. Leake, Jr.
IPC: G02B6/12 , G02B6/42 , G02B6/43 , H01S5/026 , G02B6/13 , H01L31/101 , H01S5/02345 , H01S5/02
Abstract: There is set forth herein a method including building a first photonics structure using a first wafer having a first substrate, wherein the building the first photonics structure includes integrally fabricating within a first photonics dielectric stack one or more photonics device, the one or more photonics device formed on the first substrate; building a second photonics structure using a second wafer having a second substrate, wherein the building the second photonics structure includes integrally fabricating within a second photonics dielectric stack a laser stack structure active region and one or more photonics device, the second photonics dielectric stack formed on the second substrate; and bonding the first photonics structure and the second photonics structure to define an optoelectrical system having the first photonics structure bonded the second photonics structure.
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70.发明申请公开(公告)号：US20220410171A1
公开(公告)日：2022-12-29
申请号：US17898437
申请日：2022-08-29
Inventor： Kanad Ghose
IPC: B03B1/00 , A61K36/185 , B03B5/02 , B03B11/00 , B03B5/58
Abstract: A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.
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