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185 条记录 (耗时 0.03 秒)

    Gremlin-1 antibody
    64.
    发明授权
    Gremlin-1 antibody 有权

    公开(公告)号：US10947304B2

    公开(公告)日：2021-03-16

    申请号：US16470996

    申请日：2017-12-19

    申请人： UCB BIOPHARMA SRL

    发明人： Neesha Dedi ,  Breda Twomey ,  Michael John Wright ,  Gareth Davies ,  David James McMillan

    IPC分类号： C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68 ,  A61K39/00

    摘要： This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

    Obtaining an Improved Therapeutic Ligand
    66.
    发明申请
    Obtaining an Improved Therapeutic Ligand 有权

    公开(公告)号：US20210005277A1

    公开(公告)日：2021-01-07

    申请号：US16823055

    申请日：2020-03-18

    申请人： UCB Biopharma SRL

    发明人： Jiye Shi ,  Terence Seward Baker ,  Alastair David Griffiths Lawson ,  Xiaofeng Liu

    IPC分类号： G16B5/00 ,  G16C20/90 ,  G16C20/50 ,  C07K16/24

    摘要： Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

    CHROMATOGRAPHY
    67.
    发明申请
    CHROMATOGRAPHY 审中-公开

    公开(公告)号：US20200331960A1

    公开(公告)日：2020-10-22

    申请号：US16629609

    申请日：2018-07-16

    申请人： UCB BIOPHARMA SRL

    发明人： MICHAEL HARRY ROSE

    IPC分类号： C07K1/22 ,  B01D15/38 ,  B01D15/24 ,  B01D15/18 ,  C07K1/34

    摘要： The present invention is in the field of purification and protein purification in particular. The invention provides improved techniques for the industrial-scale purification of proteins and other biomolecules. More specifically, it relates to a process for the purification of a compound of interest, such as a protein, preferably an antibody or an antibody fragment using a chromatography step, preferably a semi-continuous chromatography step.