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    ANTI-IgE ANTIBODIES
    65.
    发明申请
    ANTI-IgE ANTIBODIES 有权

    公开(公告)号：US20220235146A1

    公开(公告)日：2022-07-28

    申请号：US17541932

    申请日：2021-12-03

    Applicant: UCB BIOPHARMA SRL

    Inventor： Ralph ADAMS ,  Thomas Allen CESKA ,  Anna Marie DAVIES ,  Alistair James HENRY ,  Xiaofeng LIU ,  James Michael MCDONNELL ,  Brian John SUTTON ,  Marta Katarzyna WESTWOOD

    IPC: C07K16/42 ,  C07K16/28 ,  C07K14/735 ,  A61P37/08

    Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the FcεRI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the Cε2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the Cε2 domain of IgE) and/or the ability to disassociate IgE from the FcεRI receptor for instance at pharmaceutically-relevant concentrations. In one aspect, improved or novel treatments for IgE mediated disorders are disclosed in which IgE is targeted (for instance free IgE and/or IgE complexed with the FcεRI receptor).

    MEDICAL IMAGE ANALYSIS SYSTEM AND METHOD FOR IDENTIFICATION OF LESIONS
    66.
    发明申请
    MEDICAL IMAGE ANALYSIS SYSTEM AND METHOD FOR IDENTIFICATION OF LESIONS 有权

    公开(公告)号：US20220222816A1

    公开(公告)日：2022-07-14

    申请号：US17607307

    申请日：2020-04-28

    Applicant: UCB Biopharma SRL

    Inventor： Andrew Robert CARNELL ,  Joeri NICOLAES

    IPC: G06T7/00 ,  G06T15/08

    Abstract: A machine-based learning system for predicting the presence of lesions indicative of axial spondyloarthritis in medical imaging data includes an image processor for receiving and processing one or more MRI image data set containing pelvic region and sacroiliac joint of a subject, and dividing said MRI image data set into a set of 3D voxels. The system also includes a voxel classifier for calculating for each of said the voxels one or more class probabilities of such voxel to contain a lesion of a particular type or being a non-lesion. The system also includes a lesion probability map generator for receiving the data produced by the voxel classifier and producing a probability intensity map for each of lesion types, in which one or more areas classified as lesion are highlighted; and an image display for displaying the output of the lesion probability map generator.

    DRY MICROPARTICLES
    67.
    发明申请
    DRY MICROPARTICLES 有权

    公开(公告)号：US20220211627A1

    公开(公告)日：2022-07-07

    申请号：US17595176

    申请日：2020-05-13

    Applicant: UCB BIOPHARMA SRL

    Inventor： Audrey Françoise ARRIGHI ,  Jonathan Eleuthère Maurice GOOLE ,  Sarah MARQUETTE

    IPC: A61K9/16 ,  A61K9/19 ,  A61K39/395

    Abstract: The present invention is directed to pharmaceutical compositions, and in particular to slow release pharmaceutical compositions comprising antibody molecule-loaded polymeric microspheres, in the form of dry microparticles. The dry microparticles, and pharmaceutical compositions comprising said dry microparticles, are stable during manufacturing and upon storage and demonstrate interesting slow-release characteristics. In addition, the invention relates to methods for preparing said dry microparticles.

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