公开(公告)号：US11286266B2

公开(公告)日：2022-03-29

申请号：US17052978

申请日：2019-05-06

Applicant: UCB Biopharma SRL

Inventor： Hugues Chanteux ,  Yannick Quesnel ,  Claude Delatour ,  Laurent Provins

IPC: C07D513/04

Abstract: The present invention relates to 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US11155566B2

公开(公告)日：2021-10-26

申请号：US16771787

申请日：2018-12-04

Applicant: UCB Biopharma SRL

Inventor： Laurent Provins ,  Hugues Chanteux

IPC: C07D513/04

Abstract: The present invention relates to 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US20240083925A1

公开(公告)日：2024-03-14

申请号：US18267946

申请日：2021-12-16

Applicant: UCB Biopharma SRL

Inventor： Ali Ates ,  Celal Ates ,  Laurent Provins

IPC: C07F9/6558 ,  C07D401/06

CPC classification number: C07F9/65583 ,  C07D401/06

Abstract: The present invention relates to a prodrug of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, which prodrug is represented by formula (II).

公开(公告)号：US20240043400A1

公开(公告)日：2024-02-08

申请号：US18265156

申请日：2021-12-01

Applicant: UCB Biopharma SRL

Inventor： Ali Ates ,  Pierre Burssens ,  Adrian Hall ,  Laurent Provins ,  David Skolc ,  Anne Valade

IPC: C07D401/06 ,  C07D217/04 ,  C07D471/04 ,  C07D401/10

CPC classification number: C07D401/06 ,  C07D217/04 ,  C07D471/04 ,  C07D401/10

Abstract: The present invention relates to octahydroisoquinolinyl derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US20210047326A1

公开(公告)日：2021-02-18

申请号：US16749537

申请日：2020-01-22

Applicant: UCB Biopharma SRL

Inventor： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC: C07D471/14 ,  A61K51/04 ,  C07B59/00

Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.

公开(公告)号：US10889584B2

公开(公告)日：2021-01-12

申请号：US16480254

申请日：2018-01-23

Applicant: UCB Biopharma SRL

Inventor： Adrian Hall ,  Laurent Provins ,  Malcolm Maccoss

IPC: C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28

Abstract: The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

公开(公告)号：US11155565B2

公开(公告)日：2021-10-26

申请号：US16629776

申请日：2018-07-05

Applicant: UCB Biopharma SRL

Inventor： Laurent Provins ,  Hugues Chanteux ,  Yannick Quesnel

IPC: C07D513/04 ,  A61P25/08

Abstract: The present invention relates to 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US11155564B2

公开(公告)日：2021-10-26

申请号：US16629774

申请日：2018-07-05

Applicant: UCB Biopharma SRL

Inventor： Laurent Provins ,  Hugues Chanteux

IPC: C07D513/04 ,  A61P25/08

Abstract: The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US20210107922A1

公开(公告)日：2021-04-15

申请号：US17052978

申请日：2019-05-06

Applicant: UCB Biopharma SRL

Inventor： Hugues Chanteux ,  Yannick Quesnel ,  Claude Delatour ,  Laurent Provins

IPC: C07D513/04

Abstract: The present invention relates to 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：US11312716B2

公开(公告)日：2022-04-26

申请号：US16749537

申请日：2020-01-22

Applicant: UCB Biopharma SRL

Inventor： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC: C07D471/14 ,  A61K31/437 ,  A61K51/04 ,  C07B59/00

Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.