公开(公告)号：US20230090706A1

公开(公告)日：2023-03-23

申请号：US17905116

申请日：2021-02-26

Applicant: The University of Chicago

Inventor： Bryan DICKINSON ,  Yang CAO

IPC: C12N15/113 ,  C12N15/67

Abstract: The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA.

公开(公告)号：US20230073224A1

公开(公告)日：2023-03-09

申请号：US17904377

申请日：2021-02-17

Applicant: The University of Chicago

Inventor： David I. Schuster ,  Helin Zhang

IPC: H03K17/92 ,  G06N10/40

Abstract: Methods for initializing a qubit into a pure state, reading the qubit, and arbitrarily rotating the qubit into any quantum state complete in times shorter than the qubit's typical dephasing and relaxation times. These methods provide universal single-qubit control and may be used to implement quantum gates with high fidelity. The methods may be implemented with superconducting qubits, such as heavy fluxonium, and do not rely on a three-dimensional cavity for suppressing spontaneous emission. Therefore, the methods may be implemented using smaller two-dimensional architectures commonly used for superconducting circuits. The methods also work with low-frequency qubits, i.e., qubits for which the energy spacing between the two quantum-computational states is less than the mean thermal energy of a surrounding bath. This reduces the cooling requirements of the qubit while maintaining fidelity.

公开(公告)号：US20230071166A1

公开(公告)日：2023-03-09

申请号：US17819539

申请日：2022-08-12

Applicant: The University of Chicago

Inventor： Tong-Chuan He

IPC: C12N15/86 ,  C07K14/245

Abstract: The disclosure is directed to a gene transfer vector which comprises (i) all or part of a viral genome and (ii) a suicide gene flanked by unique cloning sequences. The disclosure also is directed to a system for producing an adenoviral vector comprising a destination vector comprising (i) all or part of an adenoviral genome and (ii) a suicide gene flanked by unique cloning sequences; a transgene flanked by unique cloning sequences; and (c) reagents for Gibson DNA Assembly (GDA). A method of producing an adenoviral vector using the aforementioned system also is provided.

公开(公告)号：US11598780B2

公开(公告)日：2023-03-07

申请号：US16753684

申请日：2018-10-05

Applicant: The University of Chicago ,  OncoTherapy Science, Inc.

Inventor： Yusuke Nakamura ,  Jae-Hyun Park ,  Sachiko Yoshimura ,  Tetsuro Hikichi

IPC: G01N33/68 ,  A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/85 ,  G01N33/50 ,  G01N33/569

Abstract: Provided herein are methods to identify TCR-recognizing cancer-specific antigens, and TCR-engineered T cells having antigen-specific cytotoxic activity. Provided herein are engineered T lymphocytes produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the engineered T lymphocytes described herein. Provided herein are antibodies, or fragments thereof, produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the antibodies described herein to a subject. In some embodiments, the therapeutic compositions (e.g., engineered lymphocytes, antibodies, etc.) and methods herein are provided as part of a kit or system.

公开(公告)号：US11575011B2

公开(公告)日：2023-02-07

申请号：US17515713

申请日：2021-11-01

Applicant: Samsung Electronics Co., Ltd. ,  THE UNIVERSITY OF CHICAGO ,  Center for Technology Licensing at Cornell University

Inventor： Minhyun Lee ,  Jiwoong Park ,  Saien Xie ,  Jinseong Heo ,  Hyeonjin Shin

IPC: H01L29/15 ,  H01L29/10

Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.

公开(公告)号：US20230021795A1

公开(公告)日：2023-01-26

申请号：US17778550

申请日：2020-11-11

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Xunshan LIU ,  Luping YU ,  Valerii SHARAPOV

IPC: C08G61/12 ,  G03F7/11

Abstract: Described herein is a novel polymerization method that is useful for synthesizing regioregular conjugated polymers from electron rich aromatic monomers and oligomers of electron rich aromatic monomers.

公开(公告)号：US20220383989A1

公开(公告)日：2022-12-01

申请号：US17773647

申请日：2020-11-03

Applicant: The University of Chicago

Inventor： Eric JONAS

IPC: G16C20/30 ,  G16C20/20 ,  G16C20/70

Abstract: A method of determining a molecular structure of a compound includes obtaining a known molecular formula of the compound based on at least one of an observed spectrum and stoichiometric calculations. Edges that meet per-vertex constraints of the molecular formula are determined, and a plurality of candidate structures is generated based on the determined edges. The plurality of candidate structures are evaluated, and one candidate structure of the plurality of candidate structures is determined as the molecular structure of the compound based on the evaluation of the plurality of candidate structures.

公开(公告)号：US20220374390A1

公开(公告)日：2022-11-24

申请号：US17641036

申请日：2020-09-09

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Frederic T. CHONG ,  Pranav GOKHALE ,  Yongshan DING ,  Thomas PROPSON

IPC: G06F15/82 ,  G06N10/40

Abstract: A computing system includes a quantum processor with qubits, a classical memory including a quantum program defining a plurality of instructions in a source language, and a classical processor configured to: (i) receive a circuit of gates representing a quantum program for a variational algorithm in which computation is interleaved with compilation; (ii) identify a plurality of blocks, each block includes a subcircuit of gates, leaving one or more remainder subcircuits of the circuit of gates outside of the plurality of blocks; (iii) pre-compile each block of the plurality of blocks with a pulse generation program to generate a plurality of pre-compiled blocks including control pulses configured to perform the associated block on the quantum processor; and (iv) iteratively execute the quantum program using the pre-compiled blocks as static during runtime and recompiling the one or more remainder subcircuits on the classical processor at each iteration of execution.

公开(公告)号：US20220362368A1

公开(公告)日：2022-11-17

申请号：US17764434

申请日：2020-10-02

Applicant: Janssen Vaccines & Prevention B.V. ,  The University of Chicago

Inventor： Jan Theunis POOLMAN ,  Olaf SCHNEEWIND ,  Dominique MISSIAKAS ,  Yan SUN ,  Hwan Keun KIM ,  Miaomiao SHI ,  Xinhai CHEN ,  Jeffrey A. FERNANDEZ

IPC: A61K39/085 ,  A61P31/04

Abstract: Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.

公开(公告)号：US20220355248A1

公开(公告)日：2022-11-10

申请号：US17728453

申请日：2022-04-25

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Steven J. Sibener ,  Michelle R. Brann ,  Stephen P. Hansknecht

IPC: B01D59/34

Abstract: Provided are apparatus and methods for enriching and separating isotopologues or isotopes. The apparatus and methods enrich and/or separate isotopes or isotopologues present in a substantially monovelocity supersonic beam incident upon a solid surface comprising condensed forms of the isotopologues or the isotopes via the differential condensation of the different isotopologues or isotopes on the surface or the differential reflection of the different isotopologues or isotopes from the surface.