公开(公告)号：US11566781B1

公开(公告)日：2023-01-31

申请号：US17855458

申请日：2022-06-30

申请人： Xin Dong

发明人： Xin Dong

IPC分类号： F21V23/00 ,  F21V23/06 ,  F21V19/00 ,  F21Y115/10 ,  F21S45/00

摘要： The present disclosure provides a light bulb for use in a lamp housing of a vehicle. The light bulb includes a bulb body assembly having one or more light sources fixedly attached thereto, and a mounting assembly configured to mount on the lamp housing. The bulb body assembly and the mounting assembly are connected by a rotatable joint such that positions of the one or more light sources can be adjusted after the mounting assembly is mounted on the lamp housing. In some embodiments, a key portion is attached to the bulb body assembly to rotate the bulb body assembly relative to the mounting assembly.

公开(公告)号：US20180161401A1

公开(公告)日：2018-06-14

申请号：US15579589

申请日：2016-07-05

申请人： Zheng Xin Dong

发明人： Zheng Xin Dong

IPC分类号： A61K38/29 ,  A61K47/10 ,  A61K9/00 ,  A61P19/10

CPC分类号： A61K38/29 ,  A61K9/0019 ,  A61K47/10 ,  A61P19/10

摘要： The present invention provides a non-buffered, neutral pH easily prepared, storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition has a non-buffered neutral pH which avoids injection site reactions and is easy to prepare and storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

公开(公告)号：US09398788B2

公开(公告)日：2016-07-26

申请号：US14411529

申请日：2013-07-01

申请人： Xin Dong

发明人： Xin Dong

IPC分类号： A43D1/06 ,  A43D1/02

CPC分类号： A43D1/06 ,  A43D1/02

摘要： Disclosed is a method for measuring inside dimensions of shoes. In this method a foot model can be obtained after the processes of a plastic filling material being filled into the shoe, shaping, being taken out from the shoe and being restored; then more accurate data of the inside dimensions of the shoe can be obtained by measuring the foot model. Further disclosed is a measuring tool able to be used in the present measuring method. By using the measuring method and the measuring tool, errors encountered when going shopping for shoes can be reduced to the maximum degree by a simple operation, such that the problem that an ordinary consumer could buy a pair of perfect fitting shoes only if he/she tries them personally can be solved.

摘要翻译： 公开了一种用于测量鞋的内部尺寸的方法。 在这种方法中，在塑料填充材料被填充到鞋中，成形，从鞋中取出并被还原之后，可以获得足部模型; 那么可以通过测量脚模型来获得鞋的内部尺寸的更准确的数据。 进一步公开的是能够用于本测量方法的测量工具。 通过使用测量方法和测量工具，通过简单的操作可以在最大程度上减少购物时遇到的错误，使普通消费者只有在他/她 尝试他们个人可以解决。

公开(公告)号：US09101547B2

公开(公告)日：2015-08-11

申请号：US13561105

申请日：2012-07-30

申请人： Yu Qian ,  Li Juan Zhang ,  Zhi Min Wu ,  Li Ying Zhou ,  Wei Jiang ,  Li Ling ,  Qian Luo ,  Xin Dong Guo

发明人： Yu Qian ,  Li Juan Zhang ,  Zhi Min Wu ,  Li Ying Zhou ,  Wei Jiang ,  Li Ling ,  Qian Luo ,  Xin Dong Guo

IPC分类号： A61K9/50 ,  A61K38/28 ,  A61K9/16 ,  A61K9/48 ,  B82Y5/00

CPC分类号： A61K9/5026 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/4891 ,  A61K38/28 ,  B82Y5/00

摘要： The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.

摘要翻译： 本发明涉及含有用于口服胰岛素递送的阳离子纳米颗粒的肠溶衣胶囊，特别涉及一种阳离子纳米颗粒，包括聚阳离子和粘膜粘附聚合物和可生物降解的聚合物，其中每种纳米颗粒具有正表面电荷并且增加细胞旁通道的渗透性 胰岛素分泌 肠溶衣胶囊还包括作为涂层的pH敏感聚合物。 包含阳离子纳米颗粒的肠溶衣胶囊当被口服给药时被配置成防止活性物质如胰岛素在从所述阳离子纳米颗粒释放到沿着胃肠道的特定吸收部位之前的酸性降解。

公开(公告)号：US08871706B2

公开(公告)日：2014-10-28

申请号：US12672681

申请日：2008-08-07

申请人： Zheng Xin Dong ,  Michael DeWitt Culler ,  Rakesh Datta ,  John E. Taylor

发明人： Zheng Xin Dong ,  Michael DeWitt Culler ,  Rakesh Datta ,  John E. Taylor

IPC分类号： A61K38/22 ,  A61K38/05 ,  A61K38/25

CPC分类号： A61K38/22 ,  A61K38/05 ,  A61K38/06 ,  A61K38/25 ,  C07K7/06 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/484

摘要： The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogous of native hGhrelin.

摘要翻译： 本发明提供了一种在需要治疗这些病症的受试者中通过施用天然的选择类似物来改善炎症，抑制促炎细胞因子和/或趋化因子表达并且治疗与发作炎症相关的各种疾病和/或病症的方法 hGhrelin。

公开(公告)号：US20130144843A1

公开(公告)日：2013-06-06

申请号：US13311034

申请日：2011-12-05

申请人： Divesh Srivastava ,  Xin Dong ,  Xuan Liu

发明人： Divesh Srivastava ,  Xin Dong ,  Xuan Liu

IPC分类号： G06F17/30

CPC分类号： G06F17/30634

摘要： An online data fusion system receives a query, probes a first source for an answer to the query, returns the answer from the first source, refreshes the answer while probing an additional source, and applies fusion techniques on data associated with an answer that is retrieved from the additional source. For each retrieved answer, the online data fusion system computes the probability that the answer is correct and stops retrieving data for the answer after gaining enough confidence that data retrieved from the unprocessed sources are unlikely to change the answer. The online data fusion system returns correct answers and terminates probing additional sources in an expeditious manner without sacrificing the quality of the answers.

摘要翻译： 在线数据融合系统接收查询，探索第一个来源以获得查询的答案，从第一个源返回答案，在探索附加的源时刷新答案，并对与检索到的答案相关联的数据应用融合技术 从额外的来源。 对于每个检索到的答案，在线数据融合系统计算出答案正确的概率，并且在获得足够的信心从而从未处理的源中检索的数据不太可能改变答案之后，停止检索答案数据。 在线数据融合系统返回正确的答案，并以迅速的方式终止探测附加来源，而不牺牲答案的质量。

公开(公告)号：US08450266B2

公开(公告)日：2013-05-28

申请号：US13057864

申请日：2009-08-07

申请人： Zheng Xin Dong ,  Yeelana Shen ,  Daniel B. DeOliveira

发明人： Zheng Xin Dong ,  Yeelana Shen ,  Daniel B. DeOliveira

IPC分类号： A61K38/00

CPC分类号： C07K14/605 ,  A61K38/00

摘要： There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide compounds, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP-receptor agonists or antagonists for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.

摘要翻译： 提供了一系列葡萄糖依赖性促胰岛素多肽化合物的类似物，含有所述化合物的药物组合物，以及所述化合物作为GIP-受体激动剂或拮抗剂用于治疗GIP-受体介导的病症例如非胰岛素依赖性 糖尿病和肥胖。

公开(公告)号：US08404804B2

公开(公告)日：2013-03-26

申请号：US12675777

申请日：2008-08-27

申请人： Zheng Xin Dong ,  John S. Eynon

发明人： Zheng Xin Dong ,  John S. Eynon

IPC分类号： C07K1/08

CPC分类号： C07K1/08 ,  C07K1/02 ,  C07K1/026 ,  C07K1/04 ,  C07K1/084 ,  C07K1/086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0821

摘要： The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

摘要翻译： 本发明涉及用于化学合成多肽和蛋白质的方法和中间体，更具体地涉及用于化学连接含有N-末端N-甲基半胱氨酸（SEQ ID NO：1）的肽片段与另一个具有 C端硫代酯，产生自发重排以形成酰胺键的（甲氨基） - 硫代酯中间体。 此外，本发明涉及将N-甲基 - 噻唑烷转化为多肽和蛋白质的N-甲基 - 半胱氨酸（SEQ ID NO：1）的方法。 本发明还涉及从肽 - 氟化物合成肽 - 硫酯的方法。

公开(公告)号：US20130030148A1

公开(公告)日：2013-01-31

申请号：US13120195

申请日：2009-09-22

申请人： Zheng Xin Dong ,  Thomas Ciaran Loughman ,  Fionn Hurley ,  Steven R. Johnson

发明人： Zheng Xin Dong ,  Thomas Ciaran Loughman ,  Fionn Hurley ,  Steven R. Johnson

IPC分类号： C07K1/04

CPC分类号： C07K14/605

摘要： The present invention relates to a process for the large-scale synthesis of (Aib8,35)hGLP-1(7-36)-NH2 (SEQ ED NO:2), i.e., His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gb-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 (SEQ ID NO:2), which comprises solid-phase Fmoc-chemistry.

摘要翻译： 本发明涉及大规模合成（Aib8,35）hGLP-1（7-36）-NH2（SEQ ID NO：2），即His-Aib-Glu-Gly-Thr-Phe -Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gb-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 （SEQ ID NO：2），其包括固相Fmoc化学。

公开(公告)号：US08339108B2

公开(公告)日：2012-12-25

申请号：US12568981

申请日：2009-09-29

申请人： Guoxing Li ,  Xin Dong

发明人： Guoxing Li ,  Xin Dong

IPC分类号： H02J7/06

CPC分类号： H02J7/0072 ,  Y02B40/90

摘要： A circuit for charging a battery may include a switch operable for conducting a current flowing through the switch, and a first amplifier coupled to the switch and operable for adjusting the current according to an amount of power dissipation associated with the switch.

摘要翻译： 用于对电池充电的电路可以包括可操作以传导流过开关的电流的开关，以及耦合到开关的第一放大器，并且可操作用于根据与开关相关联的功率量来调节电流。