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    Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery
    1.
    发明授权
    Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery 有权
    用于口服胰岛素递送的含有阳离子纳米颗粒的肠溶胶囊

    公开(公告)号：US09101547B2

    公开(公告)日：2015-08-11

    申请号：US13561105

    申请日：2012-07-30

    申请人： Yu Qian ,  Li Juan Zhang ,  Zhi Min Wu ,  Li Ying Zhou ,  Wei Jiang ,  Li Ling ,  Qian Luo ,  Xin Dong Guo

    发明人： Yu Qian ,  Li Juan Zhang ,  Zhi Min Wu ,  Li Ying Zhou ,  Wei Jiang ,  Li Ling ,  Qian Luo ,  Xin Dong Guo

    IPC分类号： A61K9/50 ,  A61K38/28 ,  A61K9/16 ,  A61K9/48 ,  B82Y5/00

    CPC分类号： A61K9/5026 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/4891 ,  A61K38/28 ,  B82Y5/00

    摘要： The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.

    摘要翻译： 本发明涉及含有用于口服胰岛素递送的阳离子纳米颗粒的肠溶衣胶囊，特别涉及一种阳离子纳米颗粒，包括聚阳离子和粘膜粘附聚合物和可生物降解的聚合物，其中每种纳米颗粒具有正表面电荷并且增加细胞旁通道的渗透性 胰岛素分泌 肠溶衣胶囊还包括作为涂层的pH敏感聚合物。 包含阳离子纳米颗粒的肠溶衣胶囊当被口服给药时被配置成防止活性物质如胰岛素在从所述阳离子纳米颗粒释放到沿着胃肠道的特定吸收部位之前的酸性降解。

    pH-sensitive nanoparticles for oral insulin delivery
    2.
    发明授权
    pH-sensitive nanoparticles for oral insulin delivery 有权
    用于口服胰岛素递送的pH敏感纳米颗粒

    公开(公告)号：US08859004B2

    公开(公告)日：2014-10-14

    申请号：US13561106

    申请日：2012-07-30

    申请人： Lijuan Zhang ,  Li Ling ,  Li Ying Zhou ,  Zhi Min Wu ,  Xin Dong Guo ,  Wei Jiang ,  Qian Luo ,  Yu Qian

    发明人： Lijuan Zhang ,  Li Ling ,  Li Ying Zhou ,  Zhi Min Wu ,  Xin Dong Guo ,  Wei Jiang ,  Qian Luo ,  Yu Qian

    IPC分类号： A61K9/51 ,  A61K38/28

    CPC分类号： A61K9/5153 ,  A61K9/5161 ,  A61K9/5192 ,  A61K38/28 ,  Y10S977/906

    摘要： The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.

    摘要翻译： 本发明公开了由pH敏感聚合物，疏水材料，内部稳定剂，外部稳定剂含量和胰岛素药物组成的pH敏感纳米颗粒。 本发明还包括用于制备pH敏感性纳米颗粒的方法，特别是多重乳液溶剂蒸发法。 本发明的pH敏感纳米颗粒具有100-300纳米粒度的良好的pH敏感性质。 在链脲佐菌素（STZ）诱导的糖尿病大鼠中观察到血糖水平的显着降低，并且口服施用负载胰岛素的pH敏感纳米颗粒后胰岛素的生物利用度大于10％。

    Message categorization
    5.
    发明授权
    Message categorization 有权
    消息分类

    公开(公告)号：US09087324B2

    公开(公告)日：2015-07-21

    申请号：US13180838

    申请日：2011-07-12

    申请人： Ivan Osipkov ,  Wei Jiang ,  Malcolm Hollis Davis ,  Douglas Hines ,  Joshua Korb

    发明人： Ivan Osipkov ,  Wei Jiang ,  Malcolm Hollis Davis ,  Douglas Hines ,  Joshua Korb

    IPC分类号： G06F15/16 ,  G06Q10/10

    CPC分类号： H04L51/22 ,  G06Q10/107 ,  H04L67/306

    摘要： One or more techniques and/or systems are provided for defining a message behavior profile for a sender, which may be used to categorize messages from the sender. A message behavior profile may be defined based upon, for example, message distribution behavior of the sender (e.g., volume, frequency, variance in content amongst messages sent to recipients, etc.); recipient interactions with messages from the sender (e.g., message read rates, message response rates, etc.); unsubscription options comprised within messages from the sender; and/or other factors. In this way, the message behavior profile and/or features extracted from a message may be used to categorize a message from the sender (e.g., newsletter, commercial advertisements, alert, social network etc.). Categorized messages may be organized into folders, displayed or hidden within views, and/or processed based upon their respective categorizations.

    摘要翻译： 提供一个或多个技术和/或系统来定义用于发送者的消息行为简档，其可以用于对来自发送者的消息进行分类。 可以基于例如发送者的消息分发行为（例如，音量，频率，发送给接收者的消息中的内容的差异等）来定义消息行为简档; 收件人与来自发送者的消息的交互（例如，消息读取速率，消息响应速率等）; 来自发件人的邮件中包含的取消订阅选项; 和/或其他因素。 以这种方式，消息行为简档和/或从消息提取的特征可以用于对来自发送者的消息进行分类（例如，通讯，商业广告，警报，社交网络等）。 分类的消息可以被组织成在视图内显示或隐藏的文件夹，和/或基于它们各自的分类进行处理。

    Electronic terminal and ring prompt method of the electronic terminal
    6.
    发明授权
    Electronic terminal and ring prompt method of the electronic terminal 有权
    电子终端的电子终端和铃声提示方法

    公开(公告)号：US08954116B2

    公开(公告)日：2015-02-10

    申请号：US13978401

    申请日：2011-04-18

    申请人： Wei Jiang

    发明人： Wei Jiang

    IPC分类号： H04B1/38 ,  H04M19/04 ,  H04M1/03

    CPC分类号： H04M19/042 ,  H04M1/035 ,  H04M19/04

    摘要： The invention discloses an electronic terminal and a ringtone prompt method for the electronic terminal. A control module of the electronic terminal instructs a ringtone sound source module to play a test ringtone signal, and instructs a ringtone channel switch system to switch all sound channels one by one to output the test ringtone signal; a sound collection module collects an exterior sound signal while each channel is outputting the test ringtone signal and feeds it back to a signal processing module; the signal processing module processes the intensity of the test ringtone signal therein; the control module determines the output channel of a prompt ringtone signal according to the processing result of the collected signal, instructs the ringtone channel switch system to switch to the determined output channel, and instructs the ringtone sound source module to play the prompt ringtone signal.

    摘要翻译： 本发明公开了一种用于电子终端的电子终端和铃声提示方法。 电子终端的控制模块指示铃声声源模块播放测试铃声信号，并指示铃声通道切换系统逐个切换所有声道以输出测试铃声信号; 声音收集模块收集外部声音信号，同时每个声道输出测试铃声信号并将其馈送回信号处理模块; 信号处理模块处理其中的测试铃声信号的强度; 控制模块根据收集信号的处理结果确定提示铃声信号的输出通道，指示铃声通道切换系统切换到确定的输出通道，并指示铃声声源模块播放提示铃声信号。

    Semiconductor structure and method for manufacturing the same
    7.
    发明授权
    Semiconductor structure and method for manufacturing the same 有权
    半导体结构及其制造方法

    公开(公告)号：US08889554B2

    公开(公告)日：2014-11-18

    申请号：US13380486

    申请日：2011-04-18

    申请人： Haizhou Yin ,  Wei Jiang ,  Zhijiong Luo ,  Huilong Zhu

    发明人： Haizhou Yin ,  Wei Jiang ,  Zhijiong Luo ,  Huilong Zhu

    IPC分类号： H01L29/78 ,  H01L29/417 ,  H01L29/66

    CPC分类号： H01L29/41775 ,  H01L29/456 ,  H01L29/6653 ,  H01L29/66545 ,  H01L29/6656

    摘要： The present invention provides a method for manufacturing a semiconductor structure, comprising: forming a first contact layer on an exposed active region of a first spacer; forming a second spacer at a region of the first contact layer close to a gate stack to partially cover the exposed active region; forming a second contact layer in the uncovered exposed active region, wherein when a diffusion coefficient of the first contact layer is the same as that of the second contact layer, the first contact layer has a thickness less than that of the second contact layer; and when the diffusion coefficient of the first contact layer is different from that of the second contact layer, the diffusion coefficient of the first contact layer is smaller than that of the second contact layer. Correspondingly, the present invention also provides a semiconductor structure. The present invention is beneficial to the suppression of the diffusion of corresponding compositions from the contact layers into the channel region, reduction of the short channel effects, and improvement of the reliability of the semiconductor structure.

    摘要翻译： 本发明提供一种制造半导体结构的方法，包括：在第一间隔物的暴露的有源区上形成第一接触层; 在所述第一接触层的靠近栅极堆叠的区域处形成第二间隔物以部分地覆盖所述暴露的有源区; 在未覆盖的暴露的有源区中形成第二接触层，其中当第一接触层的扩散系数与第二接触层的扩散系数相同时，第一接触层的厚度小于第二接触层的厚度; 并且当第一接触层的扩散系数与第二接触层的扩散系数不同时，第一接触层的扩散系数小于第二接触层的扩散系数。 相应地，本发明还提供一种半导体结构。 本发明有利于抑制相应组合物从接触层扩散到沟道区中，减少短沟道效应，提高半导体结构的可靠性。

    Electronic Terminal and Ring Prompt Method of the Electronic Terminal
    9.
    发明申请
    Electronic Terminal and Ring Prompt Method of the Electronic Terminal 有权
    电子终端电子终端和振铃提示方法

    公开(公告)号：US20140004909A1

    公开(公告)日：2014-01-02

    申请号：US13978401

    申请日：2011-04-18

    申请人： Wei Jiang

    发明人： Wei Jiang

    IPC分类号： H04M19/04

    CPC分类号： H04M19/042 ,  H04M1/035 ,  H04M19/04

    摘要： The invention discloses an electronic terminal and a ringtone prompt method for the electronic terminal. A control module of the electronic terminal instructs a ringtone sound source module to play a test ringtone signal, and instructs a ringtone channel switch system to switch all sound channels one by one to output the test ringtone signal; a sound collection module collects an exterior sound signal while each channel is outputting the test ringtone signal and feeds it back to a signal processing module; the signal processing module processes the intensity of the test ringtone signal therein; the control module determines the output channel of a prompt ringtone signal according to the processing result of the collected signal, instructs the ringtone channel switch system to switch to the determined output channel, and instructs the ringtone sound source module to play the prompt ringtone signal.

    摘要翻译： 本发明公开了一种用于电子终端的电子终端和铃声提示方法。 电子终端的控制模块指示铃声声源模块播放测试铃声信号，并指示铃声通道切换系统逐个切换所有声道以输出测试铃声信号; 声音收集模块收集外部声音信号，同时每个声道输出测试铃声信号并将其馈送回信号处理模块; 信号处理模块处理其中的测试铃声信号的强度; 控制模块根据收集信号的处理结果确定提示铃声信号的输出通道，指示铃声通道切换系统切换到确定的输出通道，并指示铃声声源模块播放提示铃声信号。

    Intelligent doghouse
    10.
    发明授权
    Intelligent doghouse 有权
    智能狗屋

    公开(公告)号：US08544418B2

    公开(公告)日：2013-10-01

    申请号：US13109244

    申请日：2011-05-17

    申请人： Wei Jiang ,  Hailong Qin

    发明人： Wei Jiang ,  Hailong Qin

    IPC分类号： A01K5/02 ,  A01K7/02 ,  A01K39/012 ,  A01K5/00

    CPC分类号： A01K1/033 ,  A01K1/0047 ,  A01K1/01 ,  A01K1/035 ,  A01K1/0356

    摘要： An intelligent doghouse full-automatic processor includes a cage bracket module, and an automatic excrement treating device, a feeding module, a water feeding module, a snack feeding module, a disinfection and heat preservation device and a video/audio module which are arranged on the cage bracket module as well as an automatic door control module, a host computer control module, a network communication module, a background control service module, a terminal use program and the like. With the modules, an owner can remotely monitor an intelligent doghouse, perform video/audio conversation with a pet dog and control and manage the eating and drinking, defecation and entering and exiting cage of the pet dog, disinfection of the cage and temperature regulation of air inside the cage by a computer or a mobile phone through a network browser. Moreover, parameters of the intelligent doghouse can be set through network.

    摘要翻译： 一种智能狗箱全自动处理器，包括一个笼托架模块，一个自动排粪处理装置，一个喂食模块，一个给水模块，一个零食喂养模块，一个消毒和保温装置以及视频/音频模块， 笼支架模块以及自动门控模块，主机控制模块，网络通信模块，后台控制服务模块，终端使用程序等。 使用模块，业主可以远程监控智能狗屋，与宠物狗进行视频/音频对话，并控制和管理宠物狗的饮食，排便和进出笼子，笼子的消毒和温度调节 通过计算机或手机通过网络浏览器在笼子内的空气。 此外，可以通过网络设置智能狗屋的参数。