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    Compositions, splice variants and methods relating to colon specific genes and proteins
    63.
    发明申请
    Compositions, splice variants and methods relating to colon specific genes and proteins 审中-公开

    公开(公告)号：US20060269918A1

    公开(公告)日：2006-11-30

    申请号：US10537402

    申请日：2003-12-04

    Applicant: Roberto Macina ,  Leah Turner ,  Yongming Sun

    Inventor： Roberto Macina ,  Leah Turner ,  Yongming Sun

    IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  A61K38/17 ,  A61K48/00 ,  C07K14/82

    CPC classification number: G01N33/57419 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886

    Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

    Compositions, splice variants and methods relating to colon specific gene and proteins
    64.
    发明申请
    Compositions, splice variants and methods relating to colon specific gene and proteins 审中-公开
    与结肠特异性基因和蛋白质有关的组合物，剪接变体和方法

    公开(公告)号：US20060269917A1

    公开(公告)日：2006-11-30

    申请号：US10537121

    申请日：2003-12-04

    Applicant: Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Maria Rodriquez

    Inventor： Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Maria Rodriquez

    IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30 ,  A61K38/17 ,  A61K48/00

    CPC classification number: G01N33/57419 ,  A61K38/00 ,  A61K39/0011 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6886

    Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

    Abstract translation: 本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

    Composition splice variants and methods relating to cancer specific genes and proteins
    65.
    发明申请
    Composition splice variants and methods relating to cancer specific genes and proteins 审中-公开
    与癌症特异性基因和蛋白质相关的组合剪接变体和方法

    公开(公告)号：US20060160090A1

    公开(公告)日：2006-07-20

    申请号：US10553436

    申请日：2004-04-12

    Applicant: Robert Macina ,  Leah Turner ,  Yongming Sun ,  Albert Tam

    Inventor： Robert Macina ,  Leah Turner ,  Yongming Sun ,  Albert Tam

    IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC classification number: C07K14/82 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57449

    Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, colon, lung, ovarian or prostate, identifying breast, colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered normal or cancerous breast, colon, lung, ovarian or prostate tissue for treatment and research.

    Abstract translation: 本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗乳腺，结肠，肺，卵巢或前列腺中的乳腺癌，结肠癌，肺癌，卵巢癌或前列腺癌和非癌性疾病状态，鉴别乳腺癌，结肠癌，肺癌，卵巢癌或卵巢癌 前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生，以及生产工程化的正常或癌性乳腺癌，结肠癌，肺癌，卵巢癌或前列腺组织用于治疗和研究。

    Compositions and methods relating to endometrial specific genes and proteins
    68.
    发明申请
    Compositions and methods relating to endometrial specific genes and proteins 审中-公开
    与子宫内膜特异性基因和蛋白质有关的组成和方法

    公开(公告)号：US20050130154A1

    公开(公告)日：2005-06-16

    申请号：US10499352

    申请日：2002-12-23

    Applicant: Yongming Sun ,  Chenghua Liu

    Inventor： Yongming Sun ,  Chenghua Liu

    IPC: A61K39/00 ,  C07H21/04 ,  C12N9/64 ,  C12Q1/68 ,  G01N33/574

    CPC classification number: G01N33/57442 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

    Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic endometrial cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating endometrial cancer and non-cancerous disease states in endometria, identifying endometrial tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered endometrial tissue for treatment and research.

    Abstract translation: 本发明涉及存在于正常和肿瘤性子宫内膜细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗子宫内膜中的子宫内膜癌和非癌性疾病状态，鉴定子宫内膜组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生，以及用于治疗和研究的工程子宫内膜组织的产生。

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