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1.发明申请Compositions, splice variants and methods relating to lung specific nucleic acids and proteins 审中-公开与肺特异性核酸和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20050142572A1
公开(公告)日：2005-06-30
申请号：US10852707
申请日：2004-05-24
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
CPC分类号： C12Q1/6886 , A61K48/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。
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2.发明申请公开(公告)号：US20070032415A1
公开(公告)日：2007-02-08
申请号：US10537695
申请日：2003-12-05
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
IPC分类号： A61K38/17 , A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07K14/47 , A61K38/00 , C07H21/04 , C12Q1/6886 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
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3.发明申请Compositions, splice variants and methods relating to colon specific genes and proteins 审中-公开与结肠特异性基因和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20060252922A1
公开(公告)日：2006-11-09
申请号：US10538002
申请日：2003-12-04
申请人： Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez , Timothy Burcham
发明人： Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez , Timothy Burcham
CPC分类号： C12Q1/6886 , A61K39/00 , C07K14/47 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。
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4.发明申请Composition, splice variants and methods relating to ovarian specific genes and proteins 审中-公开与卵巢特异性基因和蛋白质相关的组合物，剪接变体和方法公开(公告)号：US20070154886A1
公开(公告)日：2007-07-05
申请号：US10537743
申请日：2003-12-08
申请人： Roberto Macina , Leah Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto Macina , Leah Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。
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5.发明申请Compositions, splice variants and methods relating to breast specific genes and proteins 审中-公开与乳腺特异性基因和蛋白质相关的组合物，剪接变体和方法公开(公告)号：US20060205934A1
公开(公告)日：2006-09-14
申请号：US10538001
申请日：2003-12-05
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
CPC分类号： C12Q1/6886 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。
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6.发明申请公开(公告)号：US20060199180A1
公开(公告)日：2006-09-07
申请号：US10523834
申请日：2003-08-06
申请人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
发明人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
IPC分类号： C12Q1/68
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。
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7.发明申请公开(公告)号：US20060051759A1
公开(公告)日：2006-03-09
申请号：US10517696
申请日：2003-06-16
申请人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
CPC分类号： C12Q1/6886 , A61K38/00 , A61K39/00 , C07K14/4748 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。
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8.发明申请Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins 审中-公开与卵巢特异性核酸和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20050214781A1
公开(公告)日：2005-09-29
申请号：US10858412
申请日：2004-06-01
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/30 , C07K2319/60
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。
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公开(公告)号：US20050084899A1
公开(公告)日：2005-04-21
申请号：US11005609
申请日：2004-12-06
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , C12Q1/6886 , G01N33/574 , C07H21/04 , C07K14/72
CPC分类号： G01N33/57415 , A61K2039/505 , C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
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10.发明申请Compositions, splice variants and methods relating to breast specific nucleic acids and proteins 审中-公开与乳腺特异性核酸和蛋白质相关的组合物，剪接变体和方法公开(公告)号：US20050079515A1
公开(公告)日：2005-04-14
申请号：US10852074
申请日：2004-05-24
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574 , C07K14/72
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。
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