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1.发明申请Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins 审中-公开与卵巢特异性核酸和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20070166318A1
公开(公告)日：2007-07-19
申请号：US10558861
申请日：2004-06-01
Applicant: Roberto Macina , Leah Turner , Yongming Sun
Inventor： Roberto Macina , Leah Turner , Yongming Sun
IPC: A61K39/00 , C12Q1/68 , G01N33/574 , C07H21/04 , A61K48/00
CPC classification number: C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57449
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。
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2.发明申请公开(公告)号：US20060269918A1
公开(公告)日：2006-11-30
申请号：US10537402
申请日：2003-12-04
Applicant: Roberto Macina , Leah Turner , Yongming Sun
Inventor： Roberto Macina , Leah Turner , Yongming Sun
CPC classification number: G01N33/57419 , A61K38/00 , C07K14/47 , C12Q1/6886
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
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3.发明申请Compositions, splice variants and methods relating to colon specific gene and proteins 审中-公开与结肠特异性基因和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20060269917A1
公开(公告)日：2006-11-30
申请号：US10537121
申请日：2003-12-04
Applicant: Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez
Inventor： Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez
CPC classification number: G01N33/57419 , A61K38/00 , A61K39/0011 , A61K48/00 , C07K14/47 , C12Q1/6886
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。
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4.发明申请Composition splice variants and methods relating to cancer specific genes and proteins 审中-公开与癌症特异性基因和蛋白质相关的组合剪接变体和方法公开(公告)号：US20060160090A1
公开(公告)日：2006-07-20
申请号：US10553436
申请日：2004-04-12
Applicant: Robert Macina , Leah Turner , Yongming Sun , Albert Tam
Inventor： Robert Macina , Leah Turner , Yongming Sun , Albert Tam
CPC classification number: C07K14/82 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, colon, lung, ovarian or prostate, identifying breast, colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered normal or cancerous breast, colon, lung, ovarian or prostate tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗乳腺，结肠，肺，卵巢或前列腺中的乳腺癌，结肠癌，肺癌，卵巢癌或前列腺癌和非癌性疾病状态，鉴别乳腺癌，结肠癌，肺癌，卵巢癌或卵巢癌 前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生，以及生产工程化的正常或癌性乳腺癌，结肠癌，肺癌，卵巢癌或前列腺组织用于治疗和研究。
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5.发明申请Compositions, splice variants and methods relating to cancer specific genes and proteins 审中-公开与癌症特异性基因和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20060078913A1
公开(公告)日：2006-04-13
申请号：US11183261
申请日：2005-07-15
Applicant: Roberto Macina , Leah Turner , Steffan Vartanian , Shu-Hui Liu , Maria Rodriguez , Huei-Mei Chen
Inventor： Roberto Macina , Leah Turner , Steffan Vartanian , Shu-Hui Liu , Maria Rodriguez , Huei-Mei Chen
CPC classification number: C07K14/4748 , G01N33/57484
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, intestine and colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, intestine and colon, lung, ovarian or prostate, identifying breast, intestine and colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast, intestine and colon, lung, ovarian or prostate tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在乳腺，肠和结肠，肺，卵巢或前列腺中识别，诊断，监测，分期，成像和治疗乳腺，肠和结肠，肺，卵巢或前列腺癌和非癌性疾病状态，鉴定乳腺，肠和 结肠，肺，卵巢或前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生以及工程乳房，肠和结肠，肺，卵巢或前列腺组织的生产用于治疗和研究。
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Patent Agency Ranking
公开(公告)号：US20050095640A1
公开(公告)日：2005-05-05
申请号：US11013179
申请日：2004-12-15
Applicant: Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
Inventor： Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
CPC classification number: C12Q1/6809 , C12Q2545/101
Abstract: Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. Ten specific control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.
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7.发明授权Design of artificial genes for use as controls in gene expression analysis systems 失效人工基因设计用作基因表达分析系统中的对照公开(公告)号：US06943242B2
公开(公告)日：2005-09-13
申请号：US10140545
申请日：2002-05-07
Applicant: Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
Inventor： Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
CPC classification number: C12Q1/6809 , C12Q2545/101
Abstract: Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. Ten specific control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.
Abstract translation: 生产用于基因表达分析系统如大阵列，实时PCR，Northern印迹，SAGE和微阵列的对照的方法。 对照是从DNA的近随机序列或基因组的内部或内部区域产生的。 还公开了10个特异性控制序列。 还提出了使用这些对照的方法，包括作为阴性对照，阳性对照和作为基因表达分析系统的校准物。
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8.发明申请Compositions, splice variants and methods relating to lung specific nucleic acids and proteins 审中-公开与肺特异性核酸和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20050142572A1
公开(公告)日：2005-06-30
申请号：US10852707
申请日：2004-05-24
Applicant: Roberto Macina , Leah Turner , Yongming Sun
Inventor： Roberto Macina , Leah Turner , Yongming Sun
CPC classification number: C12Q1/6886 , A61K48/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。
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9.发明申请公开(公告)号：US20070032415A1
公开(公告)日：2007-02-08
申请号：US10537695
申请日：2003-12-05
Applicant: Roberto Macina , Leah Turner , Yongming Sun
Inventor： Roberto Macina , Leah Turner , Yongming Sun
CPC classification number: C07K14/47 , A61K38/00 , C07H21/04 , C12Q1/6886 , C12Q2600/112 , G01N33/57415
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
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10.发明申请Compositions, splice variants and methods relating to colon specific genes and proteins 审中-公开与结肠特异性基因和蛋白质有关的组合物，剪接变体和方法公开(公告)号：US20060252922A1
公开(公告)日：2006-11-09
申请号：US10538002
申请日：2003-12-04
Applicant: Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez , Timothy Burcham
Inventor： Roberto Macina , Leah Turner , Yongming Sun , Maria Rodriquez , Timothy Burcham
CPC classification number: C12Q1/6886 , A61K39/00 , C07K14/47 , C12Q2600/112
Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
Abstract translation: 本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。
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