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    9-Oxoxanthene-N,N{40 -bis(substituted)-2,7-disulfonamides
    63.
    发明授权
    9-Oxoxanthene-N,N{40 -bis(substituted)-2,7-disulfonamides 失效
    9-氧氧杂蒽-N，N {40-双（取代）-2,7-二磺酰胺

    公开(公告)号：US3919211A

    公开(公告)日：1975-11-11

    申请号：US33139273

    申请日：1973-02-12

    Applicant: AMERICAN HOME PROD

    Inventor： SANTILLI ARTHUR A ,  SCOTESE ANTHONY C ,  BELL STANLEY C

    IPC: C07D311/84 ,  C07D7/44 ,  C07D29/34 ,  C07D87/46

    CPC classification number: C07D311/84 ,  Y10S514/889

    Abstract: WHERE R1 is hydrogen or lower alkyl; R2 is lower alkoxy(lower)alkyl, di(lower)alkylamino (lower)alkyl, halobenzyl or morpholino(lower)alkyl; and R1 and R2 taken together with the nitrogen of the sulfonamide group are piperidino, piperazino, phenylpiperazino and morpholino. The compounds have activity as central nervous system depressants.

    The disclosure is directed to 9-oxoxanthene-N,N''bis(substituted)-2,7-disulfonamides which have the formula

    Abstract translation: 本发明涉及9-氧代呫吨-N，N'-双（取代的）-2,7-二磺酰胺，其具有下式：其中R 1是氢或低级烷基; R2是低级烷氧基（低级）烷基，二（低级）烷基氨基（低级）烷基，卤代苄基或吗啉代（低级）烷基; 并且R 1和R 2与磺酰胺基团的氮一起是哌啶子基，哌嗪基，苯基哌嗪基和吗啉代。

    1,3-Dihydro-3 -hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts in compositions and methods for inducing a calming effect
    64.
    发明授权
    1,3-Dihydro-3 -hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts in compositions and methods for inducing a calming effect 失效
    1,3-二氢-3-羟基-5-苯基-2H-1,4-苯并二氮杂-2-酮，取代二氨基乙酸酯及其酸盐，用于诱导镇静作用的组合物和方法

    公开(公告)号：US3886276A

    公开(公告)日：1975-05-27

    申请号：US41074173

    申请日：1973-10-29

    Applicant: AMERICAN HOME PROD

    Inventor： MCCAULLY RONALD J ,  NUDELMAN ABRAHAM ,  BELL STANLEY C

    IPC: A61K31/55 ,  C07D243/24 ,  C07D403/06 ,  A61K27/00

    CPC classification number: C07D243/24 ,  A61K31/55 ,  C07D403/06

    Abstract: This invention is directed to novel central nervous system depressants of Formula I:

    wherein R1 is selected from the group consisting of (lower)alkyl and ar(lower)alkyl; R2 is selected from the group consisting of di(lower)alkylamino(lower)alkyl and diaryl(lower)alkylamino(lower)alkyl; R1 and R2 may be concatenated to form a radical selected from the group consisting of

    WHEREIN R4 is selected from the group consisting of (lower)alkyl, aryl, hydroxy(lower)alkyl, ar(lower)alkyl and (lower)alkoxy(lower)alkyl; R5 is selected from the group consisting of (lower)-alkylamino and piperidino; n is an integer from 3 to 5; m is an integer from 1 - 2; r is an integer from 2 to 3; s is an integer from 0 to 6; t is an integer from 0 - 6; with the proviso that the sum of s and t is 3 to 6; R3 is selected from the group consisting of hydrogen, (lower)alkyl, ar(lower)alkyl and (lower)alkoxy(lower)alkyl; X is selected from the group consisting of halogen, cyano, trifluoromethyl, nitro and (lower)alkylthio; Y is selected from the group consisting of hydrogen, halogen, trifluoromethyl, nitro and (lower)alkylthio; and the pharmaceutically acceptable salts thereof, in addition to the method of their preparation and administration and administrable compositions containing the active compounds.

    Abstract translation: 本发明涉及式I的新型中枢神经系统抑制剂：

    Certain thiazole(3,2-a)benzimidazole compounds
    67.
    发明授权
    Certain thiazole(3,2-a)benzimidazole compounds 失效
    某些噻唑（3,2-A）苯并咪唑化合物

    公开(公告)号：US3704239A

    公开(公告)日：1972-11-28

    申请号：US3704239D

    申请日：1971-03-17

    Applicant: AMERICAN HOME PROD

    Inventor： WEI PETER H L ,  BELL STANLEY C

    IPC: C07D235/28 ,  C07D513/04 ,  C07D99/08

    CPC classification number: C07D513/04 ,  C07D235/28 ,  Y10S514/924

    Abstract: COMPOUNDS OF FORMULA I AND FORMULA II HAVE BEEN PREPARED WHICH HAVE CNS DEPRESSANT AND ANTITUBERCULAR ACTIVITY:

    1-(R2-OOC-(CH2)N-CH2-),2-((R3-PHENYL)-O-),R1-

    1,3-THIAZETIDINO(3,2-A)BENZIMIDAZOLE (I)

    1-(R2-OOC-(CH2)N-),2-(HO-),3-(R3-PHENYL),R1-2,3-DIHYDRO

    THIAZOLO(3,2-A)BENZIMIDAZOLE

    WHEREIN

    R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, (LOWER) ALKYL, TRIFLUOROMETHYL, NITRO AND AMINO; R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND (LOWER) ALKYL; R3 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, (LOWER)ALKYL, TRIFLUOROMETHYL, NITRO, AMINO, PHENYL, HALOPHENYL AND (LOWER)PHENYL; N IS AN INTEGER OF FROM 1 TO 3;

    AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

    Process for preparing 4-phenyl-quinazolines
    70.
    发明授权
    Process for preparing 4-phenyl-quinazolines 失效
    制备4-苯基喹唑啉的方法

    公开(公告)号：US3629262A

    公开(公告)日：1971-12-21

    申请号：US3629262D

    申请日：1969-09-05

    Applicant: AMERICAN HOME PROD

    Inventor： BELL STANLEY C ,  WEI PETER H L

    IPC: C07C291/02 ,  C07D51/48

    CPC classification number: C07C291/02

    Abstract: 4-PHENYLQUINAZOLINES ARE PREPARED BY REACTING A 2-AMINODIPHENYLMETHYLENEIMINOACETIC ACID N-OXIDE WITH A REACTANT SELECTED FROM THE GROUP OF LOWER ALKANOYL ANHYDRIDES AND HALO-(LOWER)ALKANOYL ANHYDRIDES TO FORM THE CORRESPONDING 2''-(A-(HYDROXYMETHYLIMINO)BENZYL)-(LOWER)ALKANOYL ANILIDE, ALKANOATE WHICH IS THEN CYCLIZED TO FORM THE 4-PHENYLQUINAZOLINES. THE PRODUCTS HAVE KNOWN PHARMACEUTICAL PROPERTIES WHICH RENDER THEM USEFUL AS MUSCLE RELAXANTS AND VASODILATORS.

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