公开(公告)号：US3691235A

公开(公告)日：1972-09-12

申请号：US3691235D

申请日：1965-06-29

Applicant: AMERICAN HOME PROD

Inventor： MCCAULLY RONALD J ,  BELL STANLEY C

IPC: A61K31/16 ,  C07D239/96 ,  C07D243/24 ,  C07D243/28 ,  C07C135/00

CPC classification number: C07D243/24 ,  A61K31/16 ,  C07D239/96 ,  C07D243/28

Abstract: A process for preparing intermediates useful in the preparation of diazepam and oxazepam type psycoleptic 1,4-benzodiazepines is described, which involves replacing in hydroxyaminoacetic acid, the hydrogen of the hydroxyl group attached to nitrogen and the hydrogen directly attached to nitrogen with acetyl groups, replacing the hydroxyl group attached to the carbonyl carbon with chlorine, and condensing the product with a 2-aminobenzophenone.

公开(公告)号：US3686210A

公开(公告)日：1972-08-22

申请号：US3686210D

申请日：1970-01-13

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  WEI PETER H L

IPC: C07D209/38 ,  C07D209/40 ,  C07D27/56

CPC classification number: C07D209/40 ,  C07D209/38

Abstract: THE INVENTION IS DIRECTED TO 2-ACRLAMIDO-3-ARYL-3$INDOL-3-OL ESTERS AND THEIR HYDROLYSIS DERIVATIVES, THE COMPOUNDS HAVE CENTRAL NERVOUS SYSTEM ACTIVITY AS DEPRESSANTS OR MAY BE USED AS INTERMEDIATES IN THE PREPARATION OF COMPOUNDS THAT HAVE SUCH ACTIVITY.

公开(公告)号：US3652547A

公开(公告)日：1972-03-28

申请号：US3652547D

申请日：1969-12-17

Applicant: AMERICAN HOME PROD

Inventor： WOLF MILTON ,  DIEBOLD JAMES L ,  BELL STANLEY C

IPC: C07D499/00 ,  C07D499/80 ,  C07D99/16

CPC classification number: C07D499/00

Abstract: THIS INVENTION IS CONCERNED WITH NOVEL 3-QUINAZOLINYLPENICILLANIC ACIDS.

公开(公告)号：US3631105A

公开(公告)日：1971-12-28

申请号：US3631105D

申请日：1970-06-08

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  MCCAULLY RONALD J ,  CHILDRESS SCOTT J

IPC: C07K1/00 ,  C07C103/44

CPC classification number: C07K1/006

Abstract: A PROCESS IS DISCLOSED IN WHICH AN N((4-OXO-4H-3,1BENZONXAZIN-2-YL) ACYLOXYMETHYL) LOWER FATTY ACID AMIDE IS PREPARED BY A REACTION OF AN ACID ANHYDRIDE WITH A SUBSTITUTED AMINOACETYL ANTHRANILIC ACID. THE REACTION PRODUCT IS THEN TREATED WITH A COMPOUND POSSESING AN ACTIVE HYDROGEN AND A NUCLEOPHILIC GROUP, I.E. AND AMINE, WHEREBY THERE IS FORMED A 2-CARBAMYL-ACETANILIDE IN WHICH ONE NUCLEOPHILIC GROUP ATTACHES TO THE METHYLENE RADICAL OF THE ACETYL GROUP AND ANOTHER TO THE CARBONYL GROUP OF THE ACETANILIDE. THE COMPOUNDS OF THE INVENTION ARE CENTRAL NERVOUS SYSTEM DEPRESSANTS, RESULTING IN A GENERALLY RELAXING OR SEDATIVE EFFECT.

公开(公告)号：US3544629A

公开(公告)日：1970-12-01

申请号：US3544629D

申请日：1968-11-12

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C

IPC: C07D285/24 ,  C07C143/78

CPC classification number: C07D285/24

公开(公告)号：US3534031A

公开(公告)日：1970-10-13

申请号：US3534031D

申请日：1967-10-23

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  MCCAULLY RONALD J ,  CHILDRESS SCOTT J

IPC: C07D213/64 ,  C07D265/22 ,  C07K1/06 ,  C07C103/50 ,  C07D87/16

CPC classification number: C07D265/22 ,  C07D213/64 ,  C07K1/064

公开(公告)号：US3516996A

公开(公告)日：1970-06-23

申请号：US3516996D

申请日：1968-02-12

Applicant: AMERICAN HOME PROD

Inventor： WEI PETER H L ,  BELL STANLEY C

IPC: C07D513/04 ,  C07D93/32

CPC classification number: C07D513/04 ,  Y10S514/867

公开(公告)号：US3505333A

公开(公告)日：1970-04-07

申请号：US3505333D

申请日：1968-02-12

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C

IPC: C07D487/04 ,  C07D57/16 ,  A61K27/00 ,  C07D49/18

CPC classification number: C07D487/04

公开(公告)号：US3475426A

公开(公告)日：1969-10-28

申请号：US3475426D

申请日：1967-11-09

Applicant: AMERICAN HOME PROD

Inventor： WEI PETER H L ,  BELL STANLEY C

IPC: C07D285/24 ,  C07D93/30

CPC classification number: C07D285/24

公开(公告)号：US3468878A

公开(公告)日：1969-09-23

申请号：US3468878D

申请日：1966-01-21

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C

IPC: C07C233/00 ,  C07D213/50 ,  C07D243/24 ,  C07D307/46 ,  C07D333/22 ,  C07D53/06 ,  A61K27/00

CPC classification number: C07D243/24 ,  C07C233/00 ,  C07D213/50 ,  C07D307/46 ,  C07D333/22