公开(公告)号：US09156856B2

公开(公告)日：2015-10-13

申请号：US13682603

申请日：2012-11-20

Applicant: AbbVie Inc.

Inventor： Aaron R. Kunzer ,  Steven W. Elmore ,  Laura A. Hexamer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M Sullivan ,  Gary T. Wang ,  Xilu Wang ,  Michael D. Wendt

IPC: C07C311/00 ,  C07D513/04 ,  C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D277/60 ,  C07D285/125 ,  C07D285/135 ,  C07D295/155 ,  C07D295/26 ,  C07D333/34 ,  C07D333/36 ,  C07D333/62 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D487/04 ,  C07D333/42

CPC classification number: C07D277/54 ,  C07C311/00 ,  C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D277/60 ,  C07D285/125 ,  C07D285/135 ,  C07D295/155 ,  C07D295/26 ,  C07D333/34 ,  C07D333/36 ,  C07D333/42 ,  C07D333/62 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20150152097A1

公开(公告)日：2015-06-04

申请号：US14559828

申请日：2014-12-03

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: C07D417/14

CPC classification number: A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US09035047B2

公开(公告)日：2015-05-19

申请号：US13868951

申请日：2013-04-23

Applicant: AbbVie Inc.

Inventor： Xilu Wang ,  Xiaohong Song ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Lisa A. Hasvold ,  Le Wang ,  Zhi-Fu Tao ,  Aaron R. Kunzer

IPC: C07D413/14 ,  A61K31/5377 ,  C07D209/42 ,  C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  C07D401/04 ,  C07D413/12

CPC classification number: C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

公开(公告)号：US08952157B2

公开(公告)日：2015-02-10

申请号：US13952278

申请日：2013-07-26

Applicant: AbbVie Inc. ,  The Walter and Eliza Hall Institue of Medical Research

Inventor： Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Laura Hexamer ,  Aaron R. Kunzer ,  Cheol-Min Park ,  Xiahong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Le Wang ,  Michael D. Wendt ,  Peter Edward Czabotar ,  Guillaume Laurent Lessene ,  Peter Malcolm Colman

IPC: C07D241/12 ,  C07D401/10 ,  C07D401/12 ,  C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D309/08

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08889675B2

公开(公告)日：2014-11-18

申请号：US13649900

申请日：2012-10-11

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: A61K31/54 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04

CPC classification number: A61K31/4725 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.