公开(公告)号：US20070022081A1

公开(公告)日：2007-01-25

申请号：US11184613

申请日：2005-07-19

申请人： Gerd Ritter

发明人： Gerd Ritter

IPC分类号： G06F17/30

CPC分类号： G06F16/20

摘要： The disclosure relates to computer systems that include 1) a data repository containing several data records and 2) several executable application processes that can cause the computer system to access the data records. A method includes accessing a data record in a data repository, the access of the data record being caused by an application process that is being executed. An electronic record of the data record access is generated, indicating the data record that was accessed and the application process that caused the data record access to occur. The record may reflect data repository access(es) performed during a client-server roundtrip. User behavior may be registered to generate recommendations for improving a data repository access strategy.

摘要翻译： 本公开涉及计算机系统，其包括1）包含若干数据记录的数据存储库和2）可使计算机系统访问数据记录的几个可执行应用程序进程。 一种方法包括访问数据存储库中的数据记录，由正在执行的应用进程引起的数据记录的访问。 生成数据记录访问的电子记录，指示访问的数据记录和导致数据记录访问的应用程序进程发生。 该记录可能反映了在客户端 - 服务器往返期间执行的数据存储库访问。 可以注册用户行为以产生改进数据存储库访问策略的建议。

公开(公告)号：US20060015878A1

公开(公告)日：2006-01-19

申请号：US10890778

申请日：2004-07-14

申请人： Gerd Ritter

发明人： Gerd Ritter

IPC分类号： G06F13/00

CPC分类号： G06F3/0489

摘要： Methods and computer program products that enable command entry portal navigation (CEPN) permit a portal user to navigate directly to a desired tile of information by entering a textual navigation command (TNC) into an input field associated with the portal. The TNC may include a command directing the computer system to interpret the TNC to determine which of a plurality of application programs is to be accessed and displayed on the portal. The TNC may also allow the user to directly perform some action within the target application by entering a single textual command. In some embodiments, the TNC may include additional commands that may be interpreted according to predefined grammar rules. In response to the TNC, the computer system may send information generated by the access to be displayed in a tile within the portal frame.

摘要翻译： 启用命令入口门户导航（CEPN）的方法和计算机程序产品允许门户用户通过将文本导航命令（TNC）输入到与门户相关联的输入字段中直接导航到期望的信息块。 TNC可以包括指示计算机系统解释TNC以确定要在门户上访问和显示多个应用程序中的哪一个的命令。 TNC还可以允许用户通过输入单个文本命令直接在目标应用程序中执行某些操作。 在一些实施例中，TNC可以包括可以根据预定义的语法规则来解释的附加命令。 响应于TNC，计算机系统可以发送由门禁帧内的瓦片中显示的访问生成的信息。

公开(公告)号：US20050216444A1

公开(公告)日：2005-09-29

申请号：US10809087

申请日：2004-03-25

申请人： Gerd Ritter ,  Volkmar Stegmann

发明人： Gerd Ritter ,  Volkmar Stegmann

IPC分类号： G06F7/00 ,  G06F17/30 ,  H04L29/12

CPC分类号： H04L29/12132 ,  G06F16/28 ,  G06F16/288 ,  H04L61/1552

摘要： One embodiment provides a method to retrieve information that contains name and relationship information. A computing system accepts input from a user to create a search request that contains a number of text characters. One or more of the text characters specify a name identifier, and one or more of the text characters specify a relationship to the name identifier. The computing system uses the search request to retrieve search results. Each search result contains the name identifier and also contains information representing the specified relationship to the name identifier. The computing system then displays to the user the name identifier for each search result in textual form.

摘要翻译： 一个实施例提供了一种检索包含名称和关系信息的信息的方法。 计算系统接受来自用户的输入以创建包含多个文本字符的搜索请求。 一个或多个文本字符指定名称标识符，并且一个或多个文本字符指定与名称标识符的关系。 计算系统使用搜索请求来检索搜索结果。 每个搜索结果包含名称标识符，并且还包含表示与名称标识符的指定关系的信息。 然后，计算系统向用户显示文本形式的每个搜索结果的名称标识符。

公开(公告)号：US06652853B2

公开(公告)日：2003-11-25

申请号：US09800522

申请日：2001-03-08

申请人： Sydney Welt ,  Nancy Kemeny ,  Gerd Ritter ,  Achim A. Jungbluth ,  Leonard Cohen ,  Lloyd J. Old

发明人： Sydney Welt ,  Nancy Kemeny ,  Gerd Ritter ,  Achim A. Jungbluth ,  Leonard Cohen ,  Lloyd J. Old

IPC分类号： A61K39395

CPC分类号： A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3046 ,  C07K2317/24 ,  A61K31/70 ,  A61K31/555 ,  A61K31/52 ,  A61K31/505 ,  A61K31/475 ,  A61K31/47 ,  A61K31/17 ,  A61K2300/00

摘要： This invention relates to a combination of immunotherapy and chemotherapy to promote tumor regression by treating a patient in need thereof with a combination of a humanized antibody that binds to A33 antigen and one or more chemotherapeutic agents. The method is useful for treating patients with colorectal cancer and gastric carcinomas. The method is particularly useful for treating patients who have tumors that are resistant to one or more chemotherapeutic agents and/or have metastasized.

公开(公告)号：US06346249B1

公开(公告)日：2002-02-12

申请号：US09543004

申请日：2000-04-04

申请人： Carlos F. Barbas, III ,  Christoph Rader ,  Gerd Ritter ,  Sydney Welt ,  Lloyd J. Old

发明人： Carlos F. Barbas, III ,  Christoph Rader ,  Gerd Ritter ,  Sydney Welt ,  Lloyd J. Old

IPC分类号： A61K39395

CPC分类号： C07K16/3046 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

摘要： The invention is directed to methods of reducing the effects of cancer in a subject by administering to said subject a pharmaceutically effective amount of an anti-cancer agent conjugated to an inmmunoglobulin product which comprises one or more novel complementarity determining region and framework regions.

摘要翻译： 本发明涉及通过向所述受试者施用药学有效量的与包含一个或多个新的互补决定区和框架区的免疫球蛋白产物缀合的抗癌剂来减少受试者中癌症的影响的方法。

公开(公告)号：US06190640B1

公开(公告)日：2001-02-20

申请号：US08752693

申请日：1996-11-19

申请人： Sydney Welt ,  Gerd Ritter ,  Leonard Cohen ,  Clarence Williams, Jr. ,  Elizabeth Carswell Richards ,  Mary John ,  Lloyd J. Old

发明人： Sydney Welt ,  Gerd Ritter ,  Leonard Cohen ,  Clarence Williams, Jr. ,  Elizabeth Carswell Richards ,  Mary John ,  Lloyd J. Old

IPC分类号： A61K5100

CPC分类号： C07K16/3046 ,  A61K38/00 ,  A61K47/6863 ,  A61K51/1063 ,  A61K2039/505 ,  A61K2121/00 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/77 ,  C07K2319/00

摘要： The invention involves the therapeutic use of humanized antibodies, fragments, etc., which bind to the antigen A33. These antibody molecules are useful in the treatment of various neoplasias, including colon cancer. Various modes of administration, and doses are described.

摘要翻译： 本发明涉及结合抗原A33的人源化抗体，片段等的治疗用途。 这些抗体分子可用于治疗各种肿瘤，包括结肠癌。 描述了各种给药方式和剂量。

公开(公告)号：US5712369A

公开(公告)日：1998-01-27

申请号：US597495

申请日：1996-02-02

申请人： Lloyd J. Old ,  Sydney Welt ,  Gerd Ritter ,  Richard J. Simpson ,  Edouard Nice ,  R. L. Moritz ,  B. Catimel ,  Hong Ji ,  Anthony W. Burgess ,  Joan K. Heath ,  Sara J. White ,  Cameron Johnstone

发明人： Lloyd J. Old ,  Sydney Welt ,  Gerd Ritter ,  Richard J. Simpson ,  Edouard Nice ,  R. L. Moritz ,  B. Catimel ,  Hong Ji ,  Anthony W. Burgess ,  Joan K. Heath ,  Sara J. White ,  Cameron Johnstone

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C07K14/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/38

CPC分类号： C07K16/3046 ,  C07K14/47 ,  C07K14/705

摘要： This invention relates to isolated protein and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor-associated antibodies, such as mAb A33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.

摘要翻译： 本发明涉及分离的蛋白质和在结肠细胞和结肠癌细胞的表面上发现的肽，以及编码所述蛋白质和肽的核酸分子。 蛋白质和肽结合肿瘤相关抗体，如mAb A33。 单体蛋白质在非还原条件下通过SDS凝胶电泳测定的分子量为约43kD。 此外，本发明涉及在诊断，筛选和治疗方法中所述核酸分子，蛋白质，单体或多聚体形式以及所述肽的抗体的用途。 本发明还涉及以单体或多聚体形式对所述蛋白质特异性的抗体以及针对所述肽的抗体。

公开(公告)号：US09928220B2

公开(公告)日：2018-03-27

申请号：US13919954

申请日：2013-06-17

申请人： Gerd Ritter ,  Guenter Wilmer

发明人： Gerd Ritter ,  Guenter Wilmer

IPC分类号： G06F17/24 ,  G06F17/21 ,  G06F17/25

CPC分类号： G06F17/218

摘要： Approaches are presented for temporary highlighting of selected fields of a document. For example, a user can select which fields of a document or class of documents he wishes to have highlighted. The user can also select (a) when he wishes the selected fields to be highlighted, for example, if a field exceeds a threshold and/or (b) how he wishes the selected fields to be highlighted, e.g., overlay the field with a contrasting color. When the user performs a specified action, for example, opens a document, the selected field is selectively highlighted according to the rules for when and how to highlight the selected field. This can help a user quickly recognize important fields in the context of the document.

公开(公告)号：US09072798B2

公开(公告)日：2015-07-07

申请号：US13201061

申请日：2010-02-17

申请人： Gerd Ritter ,  Anne Murray ,  George Mark ,  Christoph Renner

发明人： Gerd Ritter ,  Anne Murray ,  George Mark ,  Christoph Renner

IPC分类号： C07K16/28 ,  A61K51/10 ,  A61K39/395 ,  C07K16/30 ,  C07K16/42 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K31/495 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6871 ,  A61K51/103 ,  A61K51/1045 ,  A61K51/1078 ,  A61K2039/505 ,  A61K2300/00 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/4258 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

摘要翻译： 本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。 特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。 这些特异性结合成员可用于癌症的诊断和治疗。 本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

公开(公告)号：US09053445B2

公开(公告)日：2015-06-09

申请号：US13705534

申请日：2012-12-05

申请人： Frank Brunswig ,  Dirk Giebel ,  Ralph Rillig ,  Jens Weiler ,  Michael Hartel ,  Daniel Zoch ,  Gerd Ritter

发明人： Frank Brunswig ,  Dirk Giebel ,  Ralph Rillig ,  Jens Weiler ,  Michael Hartel ,  Daniel Zoch ,  Gerd Ritter

IPC分类号： G06F3/00 ,  G06Q10/06

CPC分类号： G06Q10/06

摘要： In accordance with aspects of the disclosure, a system and methods are provided for managing business objects in memory. The system and methods may be provided for defining a context of one or more input parameters of data used to determine one or more properties of one or more business objects, defining one or more rules associated with the one or more properties of each business object, and generating a metadata model for each business object based on the context of the one or more input parameters of each business object and the one or more rules associated with the one or more properties of each business object.

摘要翻译： 根据本公开的方面，提供了一种用于管理存储器中的业务对象的系统和方法。 可以提供系统和方法来定义用于确定一个或多个业务对象的一个​​或多个属性的数据的一个或多个输入参数的上下文，定义与每个业务对象的一个​​或多个属性相关联的一个或多个规则， 以及基于每个业务对象的一个​​或多个输入参数的上下文以及与每个业务对象的一个​​或多个属性相关联的一个或多个规则，为每个业务对象生成元数据模型。