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公开(公告)号：US4865845A
公开(公告)日：1989-09-12
申请号：US90720
申请日：1987-08-28
申请人： James B. Eckenhoff , John Urquhart
发明人： James B. Eckenhoff , John Urquhart
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictable alteration in delivery rate. Among other attachment means, a water soluble adhesive maintains the structure on the delivery device.
摘要翻译： 套筒形结构覆盖扩散或渗透输送装置的输送区域的一部分。 该结构对使用环境是耐用的和惰性的。 结构上的标记表明断裂或切割会产生预期的输送率变化。 在其他附着装置中，水溶性粘合剂将结构保持在输送装置上。
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62.发明授权Dispensing system with means for increasing delivery of beneficial agent from the system 失效分配系统，具有从系统中增加有益剂的输送的手段
公开(公告)号：US4844984A
公开(公告)日：1989-07-04
申请号：US173479
申请日：1988-03-24
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
摘要翻译： 公开了一种分配系统，其包括围绕管腔的壁。 所述内腔包括（1）包含有益剂的热响应组合物，（2）用于占据所述内腔中用于从所述分配系统推动所述热响应组合物的空间的装置，和（3）用于增强分配的有益剂量的装置 从位于热敏组合物和用于占据空间的装置之间的系统。
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公开(公告)号：US4717718A
公开(公告)日：1988-01-05
申请号：US895612
申请日：1986-08-11
CPC分类号： A61K9/0004 , A61M31/002
摘要： A device for the controlled delivery of a beneficial agent is disclosed. The device comprises (a) a formulation layer and (b) a layer comprising means for pushing the formualtion layer from said device. The formulation layer comprises the beneficial agent avermectin or ivermectin.
摘要翻译： 公开了一种用于控制传递有益剂的装置。 该装置包括（a）制剂层和（b）包含用于从所述装置推动制剂层的装置的层。 制剂层包含有益剂阿维菌素或伊维菌素。
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公开(公告)号：US4684524A
公开(公告)日：1987-08-04
申请号：US763493
申请日：1985-08-08
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial agent. The dispenser comprises (1) a housing defining an internal space, (2) a heat-responsive composition containing a beneficial agent in the space, (3) an osmotically effective solute in the space, and (4) at least one passageway in the housing for delivering the beneficial agent from the dispenser.
摘要翻译： 公开了用于递送有益剂的分配器。 分配器包括（1）限定内部空间的壳体，（2）在空间中含有有益剂的热响应组合物，（3）空间中的渗透有效溶质，和（4）至少一个通道 用于从分配器传送有益剂的壳体。
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公开(公告)号：US4663148A
公开(公告)日：1987-05-05
申请号：US829633
申请日：1986-02-14
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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公开(公告)号：US4643731A
公开(公告)日：1987-02-17
申请号：US766454
申请日：1985-08-16
申请人： James B. Eckenhoff
发明人： James B. Eckenhoff
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispensing system is disclosed for delivering a beneficial agent formulation instantly and continuously over time to an environment of use. The dispensing system comprises an outer housing surrounding at least a part of a dispensing device. The dispensing device comprises a wall surrounding a compartment with a passageway in the wall connecting the compartment with the interior of the dispensing device. A beneficial agent formulation is present in the housing for instant delivery and a beneficial agent formulation is present in the compartment for continuous delivery.
摘要翻译： 公开了一种分配系统，用于随着时间的推移立即和持续地将有益剂制剂递送到使用环境。 分配系统包括围绕分配装置的至少一部分的外壳。 分配装置包括围绕隔室的壁，壁中的通道将隔室与分配装置的内部连接。 在壳体中存在有益剂制剂用于即时递送，并且在隔室中存在有益剂制剂用于连续输送。
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67.发明授权Dispensing system with means for increasing delivery of beneficial agent from the system 失效分配系统，具有从系统中增加有益剂的输送的手段
公开(公告)号：US4624945A
公开(公告)日：1986-11-25
申请号：US764143
申请日：1985-08-09
CPC分类号： A61K9/0068 , A61K9/0004 , A61M31/002
摘要： A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) heat responsive means containing a beneficial agent in the space, (3) means for increasing the amount of beneficial agent delivered from the device in the space, (4) expandable means in the space, (5) an optional dense means in the space, and (6) means in the housing for delivering the beneficial agent from the dispensing device.
摘要翻译： 公开了用于递送有益剂的分配装置。 该装置包括（1）限定内部空间的壳体，（2）在该空间中含有有益试剂的热响应装置，（3）用于增加在该空间中从该装置输送的有益试剂的量的装置，（4） 在该空间中的装置，（5）该空间中可选的致密装置，以及（6）壳体中用于从分配装置输送有益剂的装置。
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68.发明授权
公开(公告)号：US4595583A
公开(公告)日：1986-06-17
申请号：US590778
申请日：1984-03-19
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining an internal space, (2) a dense member in the space, (3) a heat responsive composition containing a beneficial agent in the space, (4) an expandable member in the space, and (5) a passageway in the semipermeable housing for delivering the beneficial agent from the dispensing device.
摘要翻译： 公开了用于递送有益剂的分配装置。 该装置包括（1）限定内部空间的半透明壳体，（2）空间中的致密构件，（3）在空间中含有有益剂的热响应组合物，（4）空间中的可扩张构件，以及 （5）半透膜壳体中的通道，用于从分配装置输送有益剂。
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公开(公告)号：US4539004A
公开(公告)日：1985-09-03
申请号：US602937
申请日：1984-04-23
CPC分类号： A61M5/1409 , A61M5/145
摘要： A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a receptacle into which actuating fluid may be charged. The active agent is dispensed from the pump after the pump is exposed to the fluid. Means to vary or stop the pump by obdurating all or a portion of the exterior surface of the pump can also be provided. Variation in flow rates can also be obtained by changing the composition of the actuating fluid.
摘要翻译： 一种泵组件，其特别用作用于以基本恒定的速率肠胃外施用少量治疗活性物质长时间的输注体，包括安装在可在其中加载致动流体的容器内的流体吸收泵。 在泵暴露于流体之后，活性剂从泵中分配。 还可以提供通过使泵的全部或一部分外露而改变或停止泵的装置。 也可以通过改变致动流体的组成来获得流速的变化。
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公开(公告)号：US4300558A
公开(公告)日：1981-11-17
申请号：US170079
申请日：1980-07-18
CPC分类号： A61K9/0004
摘要： An improvement in self-driven miniature fluid dispensers is disclosed. The basic components of the dispensers are: an outer rigid semipermeable cellulose membrane that acts as a housing, an inner collapsible bag housed within the membrane that is adapted to contain the fluid, a water-imbibing composition interposed between the outer membrane and the inner bag, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged to and discharged from the dispenser. The improvement lies in using a blend of cellulose acetate butyrate and polymethylmethacrylate to make the outer membrane, thereby forming a membrane of reduced water permeability.
摘要翻译： 公开了一种改进的自驱动微型流体分配器。 分配器的基本部件是：用作壳体的外部刚性半透膜纤维素膜，容纳在膜内的适于容纳流体的内部可折叠袋;插入在外膜和内袋之间的吸水组合物 以及从袋的内部延伸到分配器的外部的端口，流体可以通过所述端口从分配器充电并从分配器排出。 改进在于使用乙酸丁酸纤维素和聚甲基丙烯酸甲酯的共混物来制造外膜，由此形成具有降低的透水性的膜。
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