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110 条记录 (耗时 0.096 秒)

    Recuperator duct assembly line
    61.
    发明授权
    Recuperator duct assembly line 有权
    换热器管道装配线

    公开(公告)号：US06668446B2

    公开(公告)日：2003-12-30

    申请号：US10001510

    申请日：2001-10-31

    申请人： Charles W. Bucey ,  Steven W. Clayton ,  Douglas R. Ervin ,  Robert M. Jones ,  Chad Miars

    发明人： Charles W. Bucey ,  Steven W. Clayton ,  Douglas R. Ervin ,  Robert M. Jones ,  Chad Miars

    IPC分类号： B23P1526

    CPC分类号： F28D9/0018 ,  B23P15/26 ,  Y10T29/49357 ,  Y10T29/5188 ,  Y10T29/53052 ,  Y10T29/53087 ,  Y10T29/53113

    摘要： An assembly line for economically and efficiently assembling a core into a recuperator. The assembly line has an inlet end, an assembly station, a welding station, a control station and an outlet end. The inlet end has a plurality of the cores to be used for assembly thereat. The core is positioned within the assembly station and an assembly fixture locates a ducting structure in a preestablished relationship to the core. The control station using a plurality of sensors sends an input to a controller and the welding station performs a weld fixedly securing the ducting structure to the core.

    摘要翻译： 一种用于经济有效地将核心组装成换热器的装配线。 装配线具有入口端，组装站，焊接站，控制站和出口端。 入口端具有用于组装的多个芯。 芯部位于组装工位内，并且组装夹具将管道结构定位成与芯部预先建立的关系。 使用多个传感器的控制站向控制器发送输入，并且焊接站执行将导管结构固定地固定到芯的焊接。

    Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
    62.
    发明申请
    Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto 审中-公开
    GPR119受体的调节剂和与之相关的疾病的治疗

    公开(公告)号：US20140051714A1

    公开(公告)日：2014-02-20

    申请号：US14113081

    申请日：2012-04-20

    申请人： Robert M. Jones

    发明人： Robert M. Jones

    IPC分类号： C07D401/14 ,  A61K45/06 ,  A61K31/506

    CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K45/06

    摘要： The present invention relates to the GPR119 agonist, 4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)-5-fluoro-6-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)pyrimidine (Compound 1): and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing the secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.

    摘要翻译： 本发明涉及GPR119激动剂，4-（1-（5-乙基嘧啶-2-基）哌啶-4-基氧基）-5-氟-6-（2-甲基-6-（甲基磺酰基） 吡啶基氧基）嘧啶（化合物1）及其药学上可接受的盐，溶剂合物和水合物，其可用作单一药剂或与一种或多种另外的药剂如DPP-IV抑制剂，双胍类， α-葡萄糖苷酶抑制剂，胰岛素类似物，磺酰脲类，SGLT2抑制剂，氯噻嗪，噻唑烷二酮或抗糖尿病肽类似物，用于治疗例如选自以下的病症：GPR119-受体相关病症; 通过增加肠降血糖素的分泌而改善的状况; 通过增加血液肠降血糖水平来改善病情; 以低骨量为特征的病症; 神经障碍 代谢相关疾病; 2型糖尿病; 肥胖; 和相关的并发症。