-
61.发明申请MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION 审中-公开DYSTROPHIA MYOTONICA - 蛋白激酶（DMPK）表达的调控公开(公告)号：US20130237585A1
公开(公告)日：2013-09-12
申请号：US13811181
申请日：2011-07-19
申请人： C. Frank Bennett , Susan M. Freier , Robert A. MacLeod , Sanjay K. Pandey , Charles A. Thornton , Thurman Wheeler , Seng H. Cheng , Andrew Leger , Bruce M. Wentworth
发明人： C. Frank Bennett , Susan M. Freier , Robert A. MacLeod , Sanjay K. Pandey , Charles A. Thornton , Thurman Wheeler , Seng H. Cheng , Andrew Leger , Bruce M. Wentworth
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y207/11 , C12N2310/322 , C12N2310/3533 , C12N2310/3527
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物体内DMPK mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于优先减少CUGexp DMPK RNA，减少肌动蛋白或减少动物中的拼接病变的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善1型肌强直营养不良症或其症状。
-
公开(公告)号：US08513400B2
公开(公告)日：2013-08-20
申请号：US12642534
申请日：2009-12-18
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
-
63.发明授权公开(公告)号：US08486904B2
公开(公告)日：2013-07-16
申请号：US12681360
申请日：2008-10-01
申请人： Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
发明人： Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
CPC分类号： C12N15/1138 , A61K31/7105 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节成纤维细胞生长因子受体4（FGFR4）的表达。 组合物包含靶向编码成纤维细胞生长因子受体4的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节成纤维细胞生长因子受体4表达和治疗与成纤维细胞生长因子受体4表达相关的疾病的方法是 提供。
-
公开(公告)号：US20120283319A1
公开(公告)日：2012-11-08
申请号：US13540097
申请日：2012-07-02
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K31/7088 , A61P3/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
-
65.发明申请Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs 有权用于调节小非编码RNA的低聚化合物和组合物公开(公告)号：US20110224277A1
公开(公告)日：2011-09-15
申请号：US12346919
申请日：2008-12-31
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K31/7125 , C07H21/02 , A61K31/712
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
-
公开(公告)号：US20110213011A1
公开(公告)日：2011-09-01
申请号：US13035772
申请日：2011-02-25
IPC分类号： A61K31/7088 , C07H21/00 , A61P17/02 , A61P43/00
CPC分类号： A61K31/7088
摘要： Provided are compounds capable of inhibiting SMAD3 and compositions containing same as well as methods using such compounds for treating fibrosis and scarring.
摘要翻译： 提供能够抑制SMAD3的化合物和含有它们的组合物以及使用这些化合物治疗纤维化和瘢痕形成的方法。
-
公开(公告)号：US20110190370A1
公开(公告)日：2011-08-04
申请号：US12642534
申请日：2009-12-18
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00 , C12N5/00
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
-
68.发明授权公开(公告)号：US07960355B2
公开(公告)日：2011-06-14
申请号：US10558216
申请日：2004-05-19
申请人： C. Frank Bennett , Susan M. Freier
发明人： C. Frank Bennett , Susan M. Freier
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , Y02P20/582 , C12N2310/3525
摘要： Antisense oligonucleotide compositions which specifically hybridize with nucleic acids encoding B7 proteins, and use of these compositions for inhibiting expression of B7 mRNA.
摘要翻译： 与编码B7蛋白的核酸特异性杂交的反义寡核苷酸组合物，以及这些组合物用于抑制B7 mRNA表达的反义寡核苷酸组合物。
-
公开(公告)号：US07919476B2
公开(公告)日：2011-04-05
申请号：US11697280
申请日：2007-04-05
申请人： Sanjay Bhanot , Lynnetta Watts , Robert McKay , Susan M. Freier
发明人： Sanjay Bhanot , Lynnetta Watts , Robert McKay , Susan M. Freier
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
-
70.发明授权公开(公告)号：US07816336B2
公开(公告)日：2010-10-19
申请号：US10511832
申请日：2003-04-21
申请人： Susan M. Freier
发明人： Susan M. Freier
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/02 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y101/01146 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of hydroxysteroid 11-beta dehydrogenase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hydroxysteroid 11-beta dehydrogenase 1. Methods of using these compounds for modulation of hydroxysteroid 11-beta dehydrogenase 1 expression and for treatment of diseases associated with expression of hydroxysteroid 11-beta dehydrogenase 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节羟基类固醇11-β脱氢酶1的表达。该组合物包含靶向编码羟基类固醇11-β脱氢酶的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节 提供羟基类固醇11-β脱氢酶1表达和用于治疗与羟基类固醇11-β脱氢酶1的表达相关的疾病。
-
-
-
-
-
-
-
-
-
搜索结果
160 条记录 (耗时 0.102 秒)
