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61.发明授权Modulation of L-selectin shedding via inhibition of tumor necrosis factor-&agr; converting enzyme (TACE) 有权通过抑制肿瘤坏死因子-α转化酶（TACE）调节L-选择素脱落公开(公告)号：US06632667B1
公开(公告)日：2003-10-14
申请号：US09429096
申请日：1999-10-28
IPC分类号： A61K3170
CPC分类号： C12N15/1137 , A61K31/00 , A61K38/00 , A61K2039/505 , C07K16/40 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/24086 , Y02P20/582 , C12N2310/3525
摘要： The present invention provides methods of modulating the shedding of L-selectin in cells or tissues using an inhibitor of TACE expression or activity. Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred forms of TACE inhibitors. These methods are believed to be useful both therapeutically and diagnostically and as research tools. The present invention further comprises methods of treating conditions associated with altered L-selectin shedding or altered L-selectin levels.
摘要翻译： 本发明提供使用TACE表达或活性抑制剂调节细胞或组织中L-选择素脱落的方法。 靶向编码TACE的核酸的反义寡核苷酸是TACE抑制剂的优选形式。 认为这些方法在治疗和诊断上都是有用的，并且作为研究工具。 本发明还包括治疗与改变的L-选择蛋白脱落或改变的L-选择素水平相关的病症的方法。
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公开(公告)号：US06613567B1
公开(公告)日：2003-09-02
申请号：US09663834
申请日：2000-09-15
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Her-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-2. Methods of using these compounds for modulation of Her-2 expression and for treatment of diseases associated with expression of Her-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Her-2的表达。 组合物包含靶向编码Her-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Her-2表达和治疗与Her-2表达相关的疾病的方法。
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公开(公告)号：US06537973B1
公开(公告)日：2003-03-25
申请号：US10025139
申请日：2001-12-18
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , A61K38/00 , C07H21/00 , C12N9/12 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q1/6876 , C12Q2600/158 , C12Y207/11013
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
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公开(公告)号：US06440739B1
公开(公告)日：2002-08-27
申请号：US09907843
申请日：2001-07-17
申请人： C. Frank Bennett , Susan M. Freier
发明人： C. Frank Bennett , Susan M. Freier
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glioma-associated oncogene-2. Methods of using these compounds for modulation of glioma-associated oncogene-2 expression and for treatment of diseases associated with expression of glioma-associated oncogene-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节胶质瘤相关致癌基因-2的表达。 组合物包含靶向编码胶质瘤相关致癌基因-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节神经胶质瘤相关致癌基因-2表达和治疗与神经胶质瘤相关致癌基因-2表达有关的疾病的方法。
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公开(公告)号：US06426220B1
公开(公告)日：2002-07-30
申请号：US09702327
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
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公开(公告)号：US06410324B1
公开(公告)日：2002-06-25
申请号：US09844634
申请日：2001-04-27
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Tumor Necrosis Factor Receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Tumor Necrosis Factor Receptor 2. Methods of using these compounds for modulation of Tumor Necrosis Factor Receptor 2 expression and for treatment of diseases associated with expression of Tumor Necrosis Factor Receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节肿瘤坏死因子受体2的表达。该组合物包含靶向编码肿瘤坏死因子受体2的核酸的反义化合物，特别是反义寡核苷酸2.使用这些化合物调节肿瘤坏死的方法 因子受体2表达和治疗与肿瘤坏死因子受体2表达相关的疾病。
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公开(公告)号：US06372433B1
公开(公告)日：2002-04-16
申请号：US09561497
申请日：2000-04-28
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Inhibitor of DNA binding-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Inhibitor of DNA binding-1. Methods of using these compounds for modulation of Inhibitor of DNA binding-1 expression and for treatment of diseases associated with expression of Inhibitor of DNA binding-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节DNA结合-1的抑制剂的表达。 组合物包含靶向编码DNA结合-1的抑制剂的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节DNA结合-1表达抑制剂和治疗与DNA结合-1抑制剂表达有关的疾病的方法。
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公开(公告)号：US06365354B1
公开(公告)日：2002-04-02
申请号：US09629645
申请日：2000-07-31
申请人： C. Frank Bennett , Jacqueline Wyatt
发明人： C. Frank Bennett , Jacqueline Wyatt
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01005 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Lysophospholipase I. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Lysophospholipase I. Methods of using these compounds for modulation of Lysophospholipase I expression and for treatment of diseases associated with expression of Lysophospholipase I are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节溶血磷脂酶I的表达。组合物包含靶向编码溶血磷脂酶I的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节溶血磷脂酶I表达和治疗疾病的方法 提供与溶血磷脂酶I的表达相关的。
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公开(公告)号：US06335194B1
公开(公告)日：2002-01-01
申请号：US09496694
申请日：2000-02-02
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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公开(公告)号：US06329203B1
公开(公告)日：2001-12-11
申请号：US09657042
申请日：2000-09-08
申请人： C. Frank Bennett , Jacqueline Wyatt
发明人： C. Frank Bennett , Jacqueline Wyatt
IPC分类号： C12N1511
CPC分类号： C12N15/1135 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glioma-associated oncogene-1. Methods of using these compounds for modulation of glioma-associated oncogene-1 expression and for treatment of diseases associated with expression of glioma-associated oncogene-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节胶质瘤相关致癌基因-1的表达。 组合物包含靶向编码胶质瘤相关致癌基因-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节神经胶质瘤相关致癌基因-1表达和治疗与神经胶质瘤相关致癌基因-1表达有关的疾病的方法。
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