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    ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN
    61.
    发明申请
    ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN 审中-公开
    抗原结合分子诱导针对目标抗原的免疫应答

    公开(公告)号：US20140255398A1

    公开(公告)日：2014-09-11

    申请号：US14347448

    申请日：2012-09-28

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

    发明人： Tomoyuki Igawa ,  Atsuhiko Maeda ,  Kenta Haraya ,  Tatsuhiko Tachibana

    IPC分类号： C07K16/28

    摘要： The present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced. Furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds.

    摘要翻译： 本发明人已经发现，在已经接受含有抗原结合结构域的生物体中，所述抗原结合分子含有与抗原结合的抗原依赖于离子浓度条件而变化，并且含有在中性中具有FcRn结合活性的FcRn结合结构域 诱导pH范围，对抗原的免疫应答。 此外，本发明人已经发现，在已经接受含有抗原结合结构域的抗原结合分子的活生物体中，所述抗原结合结构域与抗原的结合活性根据离子浓度条件而变化，并且含有具有FcRn结合活性的FcRn结合结构域 中性pH范围，诱导对抗原的免疫应答，并且抗原结合分子对癌细胞，外来生物物种或表达抗原结合分子所结合的抗原具有细胞毒性或抗增殖作用。