公开(公告)号：US20240307531A1

公开(公告)日：2024-09-19

申请号：US18588667

申请日：2024-02-27

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Alex Yee-Chen Huang ,  Jay T. Myers

IPC分类号： A61K39/395 ,  A61K31/663 ,  A61K38/17 ,  A61K39/00 ,  A61K41/17 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/28

CPC分类号： A61K39/3955 ,  A61K31/663 ,  A61K38/1774 ,  A61K41/17 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/2842 ,  A61K2039/505 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/585 ,  A61K2300/00 ,  C07K2317/76

摘要： A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/α4β1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing α4ρ1.

公开(公告)号：US20240181477A1

公开(公告)日：2024-06-06

申请号：US18418467

申请日：2024-01-22

申请人： Boehringer Ingelheim Animal Health USA Inc.

发明人： Christopher Davis Leslie ,  Ludovic Porcher

IPC分类号： B05B3/10 ,  A01K45/00 ,  A61D1/02 ,  A61K9/00 ,  A61K9/06 ,  A61K35/00 ,  A61K35/741 ,  A61K39/00 ,  A61K39/17 ,  A61K39/215 ,  A61M11/00 ,  B01F23/213 ,  B01F35/32 ,  B01F101/00 ,  B05B1/28 ,  B05B7/24 ,  B05B9/08 ,  C12N7/00

CPC分类号： B05B3/1014 ,  A01K45/00 ,  A61D1/025 ,  A61K9/0073 ,  A61K9/06 ,  A61K35/741 ,  A61K39/17 ,  A61K39/215 ,  B01F23/21311 ,  B01F35/32025 ,  B05B1/28 ,  B05B3/105 ,  B05B3/1092 ,  B05B7/2416 ,  B05B7/2478 ,  B05B9/085 ,  B05B9/0894 ,  C12N7/00 ,  A61K2035/115 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/552 ,  A61M11/00 ,  B01F2101/2202 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2770/20034 ,  C12N2770/20071

摘要： The disclosure relates to an extended-range spray applicator, and methods of making and use thereof, for dosing vaccines and/or probiotics to avian animals at a distance.

公开(公告)号：US11911468B2

公开(公告)日：2024-02-27

申请号：US17307709

申请日：2021-05-04

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Alex Yee-Chen Huang ,  Jay T. Myers

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61K45/06 ,  A61K38/17 ,  A61K31/663 ,  C07K16/28 ,  A61K41/17 ,  A61P35/04

CPC分类号： A61K39/3955 ,  A61K31/663 ,  A61K38/1774 ,  A61K41/17 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/2842 ,  A61K2039/505 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/585 ,  A61K2300/00 ,  C07K2317/76

摘要： A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/α4β1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing α4β1.

公开(公告)号：US20240042007A1

公开(公告)日：2024-02-08

申请号：US18133767

申请日：2023-04-12

申请人： Altimmune UK Ltd

发明人： Carlton Bradley Brown ,  Bertrand Victor Gilbert Georges ,  Jean Francois Thaburet

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  A61K39/12 ,  C12N7/00

CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61K47/646 ,  A61K39/12 ,  C12N7/00 ,  A61K2039/6093 ,  C12N2760/16034 ,  C12N2760/16134 ,  A61K2039/60 ,  Y02A50/30 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/544 ,  C12N2760/16122

摘要： The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles.

公开(公告)号：US11839652B2

公开(公告)日：2023-12-12

申请号：US16630744

申请日：2018-07-17

申请人： University of Saskatchewan

发明人： Susantha Gomis ,  Shelly Popowich ,  Kalhari Venukala Bandara Goonewardene ,  Suresh Tikoo ,  Marianna Foldvari

IPC分类号： A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117 ,  A61K47/69 ,  A61K47/58 ,  A61K47/61 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/24 ,  A61K39/00

CPC分类号： A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117 ,  A61K9/0078 ,  A61K47/10 ,  A61K47/183 ,  A61K47/24 ,  A61K47/58 ,  A61K47/61 ,  A61K47/6911 ,  A61K47/6929 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/6093 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2320/32

摘要： This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.

公开(公告)号：US11730803B2

公开(公告)日：2023-08-22

申请号：US17680813

申请日：2022-02-25

申请人： CASE WESTERN RESERVE UNIVERSITY ,  Trustees of Dartmouth College

发明人： Nicole F. Steinmetz ,  Amy M. Wen ,  Steven Fiering ,  Patrick H. Lizotte

IPC分类号： A61K39/125 ,  C12N7/00 ,  A61P35/04 ,  A61K39/12 ,  A61P35/00 ,  A61K31/704 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K31/704 ,  A61P35/00 ,  A61P35/04 ,  C12N7/00 ,  A61K2039/5258 ,  A61K2039/544 ,  A61K2039/585 ,  C12N2770/00023 ,  C12N2770/00034 ,  C12N2770/00071 ,  C12N2770/32022 ,  C12N2770/32023 ,  C12N2770/32034 ,  C12N2770/32071

摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

公开(公告)号：US20230256084A1

公开(公告)日：2023-08-17

申请号：US18005146

申请日：2021-07-15

申请人： INSTITUT PASTEUR ,  THERAVECTYS

发明人： Pierre CHARNEAU ,  Min-Wen KU ,  Pierre AUTHIE ,  Nicolas ESCRIOU ,  Maryline BOURGINE ,  Laleh MAJLESSI

IPC分类号： A61K39/215 ,  A61P31/14

CPC分类号： A61K39/215 ,  A61P31/14 ,  A61K2039/544

摘要： A method of inducing a protective immune response against Severe Acute Respiratory Syndrome beta-coronavirus 2 (SARS-CoV-2), comprising administering to the upper respiratory tract of a subject an effective amount of an agent that induces a protective immune response against SARS-CoV-2. A dosage form for administration to the upper respiratory tract of a pseudotyped lentiviral vector particle encoding a Severe Acute Respiratory Syndrome beta-coronavirus 2 (SARS-CoV-2) spike (S) protein or a derivative or fragment thereof.

公开(公告)号：US20230233461A1

公开(公告)日：2023-07-27

申请号：US18172403

申请日：2023-02-22

申请人： Haixiang LIN

发明人： Haixiang LIN ,  Fang LIU ,  Li ZHA ,  Xiaolin SUN

IPC分类号： A61K9/00 ,  A61K39/145 ,  A61K47/34 ,  A61K39/39 ,  A61K47/36 ,  A61K39/00

CPC分类号： A61K9/008 ,  A61K39/145 ,  A61K9/0073 ,  A61K47/34 ,  A61K39/39 ,  A61K9/0043 ,  A61K47/36 ,  A61K2039/6087 ,  A61K2039/541 ,  A61K2039/60 ,  A61K2039/543 ,  A61K2039/6093 ,  A61K2039/544

摘要： An immune preparation includes an immune substance formed by polyinosinic-polycytidylic acid, a non-antibiotic amino compound, polyethyleneimine, and at least one metal ion. The immune preparation does not include any antibiotics to prevent potential side effects. The amino compound may be chitosan oligosaccharide. The immune preparation is suitable for mucosal administration. The mucosal immune preparation facilitates mucosal immunity of human body allowing for the activation and proliferation of various immune cells.

公开(公告)号：US20190247303A1

公开(公告)日：2019-08-15

申请号：US16346051

申请日：2017-10-31

申请人： VECTURA LIMITED ,  UCB BIOPHARMA SPRL

发明人： Frazer Giles MORGAN ,  Mark Jonathan MAIN ,  Roger PALFRAMAN ,  David KIRKE

IPC分类号： A61K9/00 ,  A61K9/16 ,  C07K16/24 ,  A61P11/06

CPC分类号： A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61K2039/505 ,  A61K2039/544 ,  A61K2039/545 ,  A61P11/06 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/90

摘要： An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy chain, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:3 and a light chain, wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:1. Also described is the use of such compositions in the treatment of asthma, as well as inhalers containing such compositions.

公开(公告)号：US20190142934A1

公开(公告)日：2019-05-16

申请号：US16246652

申请日：2019-01-14

申请人： Joseph E. Kovarik

发明人： Joseph E. Kovarik

IPC分类号： A61K39/35 ,  A61K9/00 ,  A61K35/74 ,  A61K45/06 ,  A61K35/747 ,  A61K35/742 ,  A61K35/741 ,  A61K39/395 ,  A61K35/745 ,  C07K16/00 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K39/35 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/007 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K35/745 ,  A61K35/747 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/541 ,  A61K2039/544 ,  A61K2039/55 ,  A61K2039/55583 ,  A61K2039/577 ,  A61K2039/58 ,  A61K2039/70 ,  C07K16/00

摘要： A method and system for the treatment of honey bees (Apis mellifera), bats, and butterflies protects them from various life threatening conditions, including Colony Collapse Disorder, white nose syndrome, etc. and in particular, provides honey bees, bats and butterflies with the ability to assimilate and degrade pesticides such as neonicotinoids and fipronil.