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公开(公告)号：US09475776B2
公开(公告)日：2016-10-25
申请号：US14675781
申请日：2015-04-01
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Lorna Helen Mitchell , Gideon Shapiro , Richard Chesworth , Paula Ann Boriack-Sjodin
IPC: C07D231/12 , A61K31/415
CPC classification number: C07D231/12
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
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62.发明申请7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF 审中-公开HISTONE甲基转移酶的7-二氮丙啶调节剂及其使用方法公开(公告)号：US20160251390A1
公开(公告)日：2016-09-01
申请号：US14867356
申请日：2015-09-28
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
IPC: C07H19/14
CPC classification number: C07H19/14 , C07D487/04
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
Abstract translation: 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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公开(公告)号：US20160244464A1
公开(公告)日：2016-08-25
申请号：US15004224
申请日：2016-01-22
Applicant: Epizyme, Inc.
Inventor： John Emmerson Campbell , Kevin Wayne Kuntz
IPC: C07D513/04 , C07D231/56 , C07D233/64 , C07D417/12 , C07D277/28 , C07D277/64 , C07D263/56 , C07D405/12 , C07D471/04 , C07D235/14
CPC classification number: C07D513/04 , C07D231/56 , C07D233/64 , C07D235/14 , C07D263/56 , C07D277/28 , C07D277/30 , C07D277/64 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
Abstract: The present invention relates to azole compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及唑化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US09394283B2
公开(公告)日：2016-07-19
申请号：US14394431
申请日：2013-04-11
Applicant: EPIZYME, INC. , EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Frances Fang
IPC: C07D405/12
CPC classification number: A61K31/5377 , C07D405/12
Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
Abstract translation: 本文提供的是N - （（4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基）甲基）-5-（乙基（四氢-2H-吡喃-4-基）氨基）-4- 甲基-4' - （吗啉代甲基） - [1,1'-联苯] -3-甲酰胺氢溴酸盐。 本文还提供了该化合物的特定多晶型物。
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公开(公告)号：US20160031907A1
公开(公告)日：2016-02-04
申请号：US14774935
申请日：2014-03-14
Applicant: EPIZYME, INC.
Inventor： John Emmerson Campbell , Kevin Wayne Kuntz
IPC: C07D513/04 , C07D231/56 , C07D233/61 , C07D405/12 , C07D277/28 , C07D277/64 , C07D263/56 , C07D471/04 , C07D235/14
CPC classification number: C07D513/04 , C07D231/12 , C07D231/56 , C07D233/61 , C07D233/64 , C07D235/06 , C07D235/14 , C07D263/56 , C07D277/28 , C07D277/64 , C07D401/06 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: The present invention relates to compounds of Formula (I), wherein the variables are as defined herein. Pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof are disclosed.
Abstract translation: 本发明涉及式（I）的化合物，其中变量如本文所定义。 公开了含有这些化合物的药物组合物和通过将这些化合物和药物组合物给予需要的受试者来治疗癌症的方法。
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Patent Agency Ranking
公开(公告)号：US20160024081A1
公开(公告)日：2016-01-28
申请号：US14774937
申请日：2014-03-14
Applicant: EPIZYME, INC.
Inventor： John Emmerson Campbell , Kevin Wayne Kuntz
IPC: C07D471/04 , C07D231/56
CPC classification number: C07D471/04 , C07D231/56
Abstract: The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及唑类双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US09206157B2
公开(公告)日：2015-12-08
申请号：US14733690
申请日：2015-06-08
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Edward James Olhava , Richard Chesworth , Kenneth William Duncan
IPC: C07D401/12 , C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
CPC classification number: C07D401/12 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的6,5-稠合双环杂芳基化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。
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公开(公告)号：US20150284334A1
公开(公告)日：2015-10-08
申请号：US14675781
申请日：2015-04-01
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Lorna Helen Mitchell , Gideon Shapiro , Richard Chesworth , Paula Ann Boriack-Sjodin
IPC: C07D231/12
CPC classification number: C07D231/12
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
Abstract translation: 本文描述了式（I）的化合物，其药学上可接受的盐及其药物组合物。 本文所述的化合物可用于抑制PRMT1活性。 还描述了使用该化合物治疗PRMT1介导的病症的方法。
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公开(公告)号：US09089575B2
公开(公告)日：2015-07-28
申请号：US14639878
申请日：2015-03-05
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki
IPC: A61K31/535 , A61K31/44 , C07D213/64 , A61K31/445 , C07D211/68 , A61K31/5377 , A61K31/4412 , A61K31/4545
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20140288141A1
公开(公告)日：2014-09-25
申请号：US14212354
申请日：2014-03-14
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Lorna Helen Mitchell , Gideon Shapiro , Richard Chesworth , Paula Ann Boriack-Sjodin
IPC: C07D231/12
CPC classification number: C07D231/12
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
Abstract translation: 本文描述了式（I）的化合物，其药学上可接受的盐及其药物组合物。 本文所述的化合物可用于抑制PRMT1活性。 还描述了使用该化合物治疗PRMT1介导的病症的方法。
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