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Patent Agency Ranking
1.发明申请7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF 审中-公开HISTONE甲基转移酶的7-二氮丙啶调节剂及其使用方法公开(公告)号：US20160251390A1
公开(公告)日：2016-09-01
申请号：US14867356
申请日：2015-09-28
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
IPC: C07H19/14
CPC classification number: C07H19/14 , C07D487/04
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
Abstract translation: 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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2.发明授权7-deazapurine modulators of histone methyltransferase, and methods of use thereof 有权组氨酸甲基转移酶的7-脱氮嘌呤调节剂及其使用方法公开(公告)号：US08722877B2
公开(公告)日：2014-05-13
申请号：US14018171
申请日：2013-09-04
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
CPC classification number: C07H19/14 , C07D487/04
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
Abstract translation: 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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公开(公告)号：US20170198006A1
公开(公告)日：2017-07-13
申请号：US15321280
申请日：2015-06-25
Applicant: Epizyme, Inc.
Inventor： Kenneth W. Duncan , Richard Chesworth , Gideon Shapiro , Edward James Olhava , Michael A. Patane , Michael John Munchhof , Kevin Wayne Kuntz , Lei Jin
IPC: C07H19/16 , C07D405/06 , C07D401/12 , C07D403/04 , C07C311/41 , C07D233/64 , C07D207/14
CPC classification number: C07H19/16 , A61P3/00 , A61P3/10 , A61P7/00 , A61P35/00 , C07C311/41 , C07D205/04 , C07D207/14 , C07D207/273 , C07D211/28 , C07D231/12 , C07D233/64 , C07D233/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12 , C07D487/04 , C07D513/04 , C07H19/167
Abstract: Described herein are compounds of Formula (I)-(XIII), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
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公开(公告)号：US20160068559A1
公开(公告)日：2016-03-10
申请号：US14680339
申请日：2015-04-07
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
IPC: C07H19/16
CPC classification number: C07H19/16 , C07D473/34 , C07H19/167
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.
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5.发明申请7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof 有权组氨酸甲基转移酶的7-脱氮嘌呤调节剂及其使用方法公开(公告)号：US20140073597A1
公开(公告)日：2014-03-13
申请号：US14018171
申请日：2013-09-04
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Kevin Wayne Kuntz , Edward James Olhava , Michael A. Patane
IPC: C07H19/14
CPC classification number: C07H19/14 , C07D487/04
Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
Abstract translation: 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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