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79 条记录 (耗时 0.037 秒)

    Antibodies specific for DKK-1 and their uses
    64.
    发明授权
    Antibodies specific for DKK-1 and their uses 失效
    特异于DKK-1的抗体及其用途

    公开(公告)号：US08338576B2

    公开(公告)日：2012-12-25

    申请号：US12777806

    申请日：2010-05-11

    申请人： Vishwas Madhav Paralkar ,  Donna Marie Stone ,  Mei Li ,  Jaume Pons

    发明人： Vishwas Madhav Paralkar ,  Donna Marie Stone ,  Mei Li ,  Jaume Pons

    IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/70 ,  C12N15/85

    摘要： The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone. Methods of treating or preventing a loss of bone mass, methods of inducing increased bone mass, and methods of inducing Wnt activity are also provided.

    摘要翻译： 本发明提供了与Dkk-1结合的抗体及其片段，特别是结合Dkk-1的人源化抗体及其片段，更具体地，涉及与Dkk-1结合的完全人源化抗体和免疫功能片段 。 还提供了与抗小鼠Dkk-1单克隆抗体与Dkk-1 +细胞的结合竞争的抗体及其片段。 还提供了编码抗-Dkk-1抗体或其片段的核酸，以及掺入这些核酸用于重组表达抗-Dkk-1抗体及其片段的表达载体和宿主细胞。 还提供了制备本发明的抗体及其片段的方法。 还提供骨合成代谢剂。 还提供了包含本发明的抗体或其片段的药物组合物。 还提供了治疗导致骨丢失的疾病，病症和障碍（例如骨骼疾病）的方法。 还提供了治疗或预防骨量丧失的方法，诱导骨量增加的方法和诱导Wnt活性的方法。

    Customs information system with selective transaction audit
    67.
    发明授权
    Customs information system with selective transaction audit 有权
    海关信息系统有选择性的交易审核

    公开(公告)号：US08103605B2

    公开(公告)日：2012-01-24

    申请号：US10121268

    申请日：2002-04-12

    申请人： Mei Li ,  Theresa M. Ellis

    发明人： Mei Li ,  Theresa M. Ellis

    IPC分类号： G06Q30/00

    CPC分类号： G06Q10/10 ,  G06Q30/0619

    摘要： A system for generating and auditing customs documents for the importation of goods purchased by a buyer from a seller. The system includes a customs information system database that features records configured to record transaction information identifying the goods purchased, a customs classification of the purchased goods, and a valuation of the purchased goods. The system further includes an audit module configured periodically to audit the information in the records using a set of audit criteria. The audit module selectively audits only records containing transaction information that has been sent to a customs broker to be submitted to a customs authority.

    摘要翻译： 用于生成和审核由买方从卖方购买的货物进口的海关文件的制度。 该系统包括一个海关信息系统数据库，其中记录配置为记录识别所购货物的交易信息，所购货物的海关分类和所购商品的估价。 该系统还包括周期性地配置的审核模块，以使用一组审核标准对记录中的信息进行审核。 审计模块仅选择性地审核包含已经发送给海关经纪人以提交给海关当局的交易信息的记录。