公开(公告)号：US4233241A

公开(公告)日：1980-11-11

申请号：US31634

申请日：1979-04-19

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07C275/40 ,  C07C103/375

CPC分类号： A61K8/415 ,  A61K8/413 ,  A61Q5/10 ,  C07C275/40

摘要： Diphenylamine which is N-monosubstituted in the 4'-position carries at least one acylamino group at the 2- or 6-position. The diphenylamine is usefully employed in a composition for dyeing keratinic fibers.

摘要翻译： 在4'-位上被N-单取代的二苯胺在2-或6-位带有至少一个酰氨基。 二苯胺可用于染色角蛋白纤维的组合物中。

公开(公告)号：US4204064A

公开(公告)日：1980-05-20

申请号：US871839

申请日：1978-01-24

申请人： Gregoire Kalopissis

发明人： Gregoire Kalopissis

IPC分类号： A61K8/44 ,  A61K8/46 ,  A61Q5/00 ,  A61Q19/00 ,  C07D211/20 ,  C07D213/82

CPC分类号： C07D213/82 ,  A61K8/447 ,  A61K8/46 ,  A61Q19/008 ,  A61Q5/00 ,  A61Q5/008 ,  Y10S424/04

摘要： A method, composition and compounds useful in said compositions for treating the skin and scalp characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum includes topically applying to a human having skin and/or a scalp so characterized a cosmetic composition containing as an active ingredient a derivative of cysteine or cysteamine. The composition contains about 0.1-5 weight percent of said derivative and also contains as a carrier for the active ingredient, water, a mixture of water and a lower alkanol, a lower alkanol, a mixture of a lower alkanol and a cosmetic resin, a reducing agent, a neutralizing agent or a vegetable oil.

摘要翻译： 用于治疗皮肤和头皮的所述组合物中的用于治疗皮肤和头皮的方法，组合物和化合物，其特征在于通过减少皮脂的过度分泌来改善其状况，从而局部施用于具有皮肤和/或头皮的人 含有半胱氨酸或半胱胺衍生物作为活性成分的化妆品组合物。 该组合物含有约0.1-5重量％的所述衍生物，并且还含有活性成分的载体，水，水和低级链烷醇的混合物，低级链烷醇，低级链烷醇和化妆品树脂的混合物， 还原剂，中和剂或植物油。

公开(公告)号：US4112229A

公开(公告)日：1978-09-05

申请号：US798011

申请日：1977-05-18

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07C275/40 ,  C09B53/02 ,  C07D265/14

CPC分类号： C07C275/40 ,  A61K8/413 ,  A61Q5/10 ,  C09B53/02

摘要： Diphenylamines of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halogen or lower alkyl containing 1-4 carbon atoms with at least one of R.sub.1 and R.sub.2 being other than hydrogen; R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 each independently represent hydrogen or lower alkyl optionally substituted with hydroxy, carbamyl, piperidinyl or acylamino; R.sub.3 and R.sub.6 or R.sub.4 and R.sub.7 also optionally forming together with the carbon and nitrogen atoms to which they are attached, a dihydrooxazine or pyrroline heterocycle; and Z represents amino, acylamino or hydroxy; and the acid salts of said diphenylamines. These diphenylamines are usefully employed in cosmetic compositions for the hair including hair dye compositions and hair setting lotion compositions.

摘要翻译： 其中R 1和R 2各自独立地表示氢，卤素或含有1-4个碳原子的低级烷基，其中R 1和R 2中的至少一个不是氢; R3，R4，R5，R6和R7各自独立地表示氢或任选被羟基，氨基甲酰基，哌啶基或酰基氨基取代的低级烷基; R 3和R 6或R 4和R 7还任选地与它们所连接的碳原子和氮原子一起形成，二氢恶嗪或吡咯啉杂环; Z表示氨基，酰氨基或羟基; 和所述二苯胺的酸式盐。 这些二苯胺可用于头发的化妆品组合物中，包括染发组合物和头发定型洗剂组合物。

公开(公告)号：US4101576A

公开(公告)日：1978-07-18

申请号：US762329

申请日：1977-01-25

申请人： Gregoire Kalopissis ,  Andree Bugaut

发明人： Gregoire Kalopissis ,  Andree Bugaut

IPC分类号： C07C103/29 ,  C07C103/76

CPC分类号： A61K8/42 ,  A61Q5/10

摘要： The dye coupling compounds 2-carbamylmethylamino-4-hydroxy toluene and 2-diethylcarbamylmethylamino-4-hydroxy toluene.

摘要翻译： 染料偶联化合物2-氨基甲酰基甲基氨基-4-羟基甲苯和2-二乙基氨基甲酰基甲基氨基-4-羟基甲苯。

公开(公告)号：US4085217A

公开(公告)日：1978-04-18

申请号：US714000

申请日：1976-08-12

申请人： Gregoire Kalopissis

发明人： Gregoire Kalopissis

IPC分类号： A61K8/44 ,  A61K8/46 ,  A61Q5/00 ,  A61Q19/00 ,  C07D213/82 ,  C07K1/00 ,  A61K31/455

CPC分类号： C07K1/006 ,  A61K8/447 ,  A61K8/46 ,  A61Q19/008 ,  A61Q5/00 ,  A61Q5/008 ,  C07D213/82 ,  A61Q5/02 ,  Y10S514/846 ,  Y10S514/859

摘要： A method, composition and compounds useful in said compositions for treating the skin and scalp characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum includes topically applying to a human having skin and/or a scalp so characterized a cosmetic composition containing as an active ingredient a derivative of cysteine or cysteamine. The composition contains about 0.1-5 weight percent of said derivative and also contains as a carrier for the active ingredient, water, a mixture of water and a lower alkanol, a lower alkanol, a mixture of a lower alkanol and a cosmetic resin, a reducing agent, a neutralizing agent or a vegetable oil.

摘要翻译： 用于治疗皮肤和头皮的所述组合物中的用于治疗皮肤和头皮的方法，组合物和化合物，其特征在于通过减少皮脂的过度分泌来改善其状况，从而局部施用于具有皮肤和/或头皮的人 含有半胱氨酸或半胱胺衍生物作为活性成分的化妆品组合物。 该组合物含有约0.1-5重量％的所述衍生物，并且还含有活性成分的载体，水，水和低级链烷醇的混合物，低级链烷醇，低级链烷醇和化妆品树脂的混合物， 还原剂，中和剂或植物油。

公开(公告)号：US4067869A

公开(公告)日：1978-01-10

申请号：US727480

申请日：1976-09-28

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07D213/74 ,  D06P3/08

CPC分类号： C07D213/74 ,  A61K8/413 ,  A61Q5/10 ,  D06P3/08

摘要： A process for producing indamine by condensing 2,6-diamino pyridine on a paraphenylene diamine or a benzoquinone diimine or a paranitroso N,N-dialkyl aniline. The resulting indamine can be incorporated into a dye composition for keratinic fibers, especially human hair.

摘要翻译： 通过在对苯二胺或苯醌二亚胺或亚硝基二氮烷N，N-二烷基苯胺上缩合2,6-二氨基吡啶来制备吲哚的方法。 所得的吲哚胺可以并入用于角质纤维，特别是人类头发的染料组合物中。

公开(公告)号：US4054147A

公开(公告)日：1977-10-18

申请号：US551662

申请日：1975-02-21

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07C275/40 ,  A61K7/13

CPC分类号： A61K8/415 ,  A61K8/413 ,  A61Q5/10 ,  C07C275/40 ,  Y10S424/01 ,  Y10S424/02

摘要： Diphenylamine of the formula ##STR1## wherein R.sub.1 and R.sub.4 each independently represent a member selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, amino, lower alkyl amino, acylamino, lower carbamylalkyl amino, lower hydroxyalkyl amino, lower carbalkoxy amino and ureido;R.sub.2 and R.sub.3 each independently represent a member selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, acylamino and ureido;R.sub.5 represents a member selected from the group consisting of hydrogen, halogen, lower alkyl and lower alkoxy;R.sub.6 represents a member selected from the group consisting of lower hydroxyalkyl, lower amino alkyl, lower acylamino alkyl, lower mesylamino alkyl, lower carbamylalkyl, lower sulfoalkyl, lower piperidinoalkyl, lower morpholinoalkyl, lower mono alkyl lower amino alkyl and lower dialkyl lower amino alkyl; andR.sub.7 represents a member selected from the group consisting of lower alkyl, lower hydroxyalkyl, lower aminoalkyl, lower acylamino alkyl, lower mesylamino alkyl, lower carbamyl alkyl, lower sulfoalkyl, lower piperidinoalkyl, lower morpholinoalkyl, lower monoalkyl lower amino alkyl and lower dialkyl lower amino alkyl, each of said alkyl and alkoxy moieties containing 1-6 carbon atoms and each of said acyl moieties representing R-CO- wherein R is selected from the group consisting of an aliphatic and aromatic group.The said diphenylamine is usefully employed in a dye composition for dyeing keratinic fibers.

摘要翻译： 其中R 1和R 4各自独立地表示选自氢，卤素，低级烷基，低级烷氧基，氨基，低级烷基氨基，酰氨基，低级氨基甲酰基烷基氨基，低级羟烷基氨基，低级烷氧基 氨基和脲基; R2和R3各自独立地表示选自氢，卤素，低级烷基，低级烷氧基，酰氨基和脲基的成员; R5表示选自氢，卤素，低级烷基和低级烷氧基的成员; R6代表选自低级羟烷基，低级氨基烷基，低级酰氨基烷基，下甲磺酰氨基烷基，低级氨基甲酰基烷基，低级磺基烷基，低级哌啶子基烷基，低级吗啉代烷基，低级单烷基低级氨基烷基和低级二烷基低级氨基烷基的成员。 并且R 7表示选自低级烷基，低级羟烷基，低级氨基烷基，低级酰氨基烷基，下甲磺酰氨基烷基，低级氨基甲酰基烷基，低级磺基烷基，低级哌啶子基烷基，低级吗啉代烷基，低级单烷基低级氨基烷基和低级二烷基低级 氨基烷基，所述烷基和烷氧基部分各自含有1-6个碳原子，并且每个所述酰基部分代表R-CO-，其中R选自脂族和芳族基团。

公开(公告)号：US4046786A

公开(公告)日：1977-09-06

申请号：US619477

申请日：1975-10-03

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07C275/26 ,  C07D295/13 ,  C07D295/135 ,  C07C119/12 ,  C07C127/17 ,  C07C143/75

CPC分类号： C07D295/135 ,  A61K8/413 ,  A61Q5/10 ,  C07C275/26 ,  C07D295/13 ,  Y10S424/01 ,  Y10S424/02

摘要： Indoaniline of the formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, alkyl or alkoxy;R.sub.2 represents alkyl, hydroxyalkyl, carbamylalkyl, piperidinoalkyl, morpholinoalkyl, sulfoalkyl, dialkylaminoalkyl, acylaminoalkyl, (preferably acetylaminoalkyl or benzoylaminoalkyl) and mesylaminoalkyl;R.sub.3 represents hydroxyalkyl, carbamylalkyl, piperidinoalkyl, morpholinoalkyl, sulfoalkyl, dialkylaminoalkyl, acylaminoalkyl, (preferably acetylaminoalkyl or benzoylaminoalkyl), mesylaminoalkyl; or R.sub.2 and R.sub.3 together form with the nitrogen atom to which they are attached a heterocycle selected from piperidino or morpholino;R.sub.4, r.sub.5 and R.sub.6 each independently represents hydrogen, halogen, alkyl, alkoxy, acylamino, ureido or carbalkoxyamino, and R.sub.5 can also represent amino, alkylamino, hydroxyalkylamino or carbamylalkylamino. The alkyl and alkoxy groups above can contain from 1 to 6 carbon atoms and the acyl group can contain from 2 to 7 carbon atoms. The present invention also relates to a process for the preparation of the above indoanilines and to dye compositions for keratinic fibers, and in particular living human hair, containing said indoanilines.

摘要翻译： 其中R 1表示氢，卤素，烷基或烷氧基; R 2表示烷基，羟基烷基，氨基甲酰基烷基，哌啶子基烷基，吗啉代烷基，磺基烷基，二烷基氨基烷基，酰氨基烷基（优选乙酰氨基烷基或苯甲酰基氨基烷基）和甲磺酰氨基烷基; R 3表示羟烷基，氨基甲酰基烷基，哌啶子基烷基，吗啉代烷基，磺基烷基，二烷基氨基烷基，酰氨基烷基（优选乙酰氨基烷基或苯甲酰氨基烷基），甲磺酰氨基烷基; 或者R 2和R 3与它们所连接的氮原子一起形成选自哌啶子基或吗啉代的杂环; R 4，R 5和R 6各自独立地表示氢，卤素，烷基，烷氧基，酰氨基，脲基或烷氧基氨基，R 5也可以表示氨基，烷基氨基，羟基烷基氨基或氨基甲酰基烷基氨基。 上述烷基和烷氧基可含有1至6个碳原子，酰基可含有2至7个碳原子。 本发明还涉及制备上述吲哚苯胺的方法和用于角蛋白纤维的染色组合物，特别是包含所述吲哚苯胺的活人的头发。

公开(公告)号：US4008272A

公开(公告)日：1977-02-15

申请号：US578318

申请日：1975-05-16

申请人： Gregoire Kalopissis ,  Jean Gascon ,  Andree Bugaut ,  Jacqueline Gallien ,  Hubert Gaston-Breton

发明人： Gregoire Kalopissis ,  Jean Gascon ,  Andree Bugaut ,  Jacqueline Gallien ,  Hubert Gaston-Breton

IPC分类号： C07C275/14 ,  C07C127/15 ,  C07C87/52

CPC分类号： A61K8/42 ,  A61Q5/10 ,  C07C275/14

摘要： Dye compositions containing the oxidation dye: ##STR1## and the method of using it to dye live human hair.

摘要翻译： 含有氧化染料的染料组合物：＆lt; IMAGE＆gt;和使用它染色活人的头发的方法。

公开(公告)号：US4008043A

公开(公告)日：1977-02-15

申请号：US551627

申请日：1975-02-21

申请人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

发明人： Gregoire Kalopissis ,  Andree Bugaut ,  Francoise Estradier

IPC分类号： A61K8/41 ,  A61Q5/10 ,  C07C275/40 ,  A61K7/13

CPC分类号： A61K8/415 ,  A61K8/413 ,  A61Q5/10 ,  C07C275/40

摘要： Diphenylamine of the formula: ##STR1## wherein R.sub.1 and R.sub.4 each independently represent a member selected from the group consisting of hydrogen, halogen, lower alkyl having 1-6 carbon atoms, lower alkoxy having 1-6 carbon atoms, amino, N-lower alkyl amino wherein the alkyl moiety has 1-6 carbon atoms, N-lower hydroxy alkyl amino wherein the alkyl moiety has 1-6 carbon atoms, N-lower carbamylalkyl amino wherein the alkyl moiety has 1-6 carbon atoms, acylamino, wherein the acyl moiety has 2-7 carbon atoms, ureido and carbalkoxyamino wherein the alkoxy moiety has 1-6 carbon atoms;R.sub.2 and R.sub.3 each independently represent a member selected from the group consisting of hydrogen, halogen, lower alkyl having 1-6 carbon atoms, lower alkoxy having 1-6 carbon atoms, acylamino wherein the acyl moiety has 2-7 carbon atoms and ureido;R.sub.5 and R.sub.6 each independently represent a member selected from the group consisting of hydrogen, halogen, lower alkyl having 1-6 carbon atoms and lower alkoxy having 1-6 carbon atoms with the proviso that when both R.sub.5 and R.sub.6 are other than hydrogen at least one of R.sub.5 and R.sub.6 occupies a position meta to --NHR.sub.7 ; andR.sub.7 represents a member selected from the group consisting of alkyl having 1-6 carbon atoms, hydroxy alkyl having 1-6 carbon atoms, amino alkyl having 1-6 carbon atoms, acylamino alkyl wherein the acyl moiety has 2-7 carbon atoms and the alkyl moiety has 1-6 carbon atoms, mesylamino alkyl having 1-6 carbon atoms, carbamyl alkyl having 1-6 carbon atoms, sulfo alkyl having 1-6 carbon atoms, piperidino alkyl having 1-6 carbon atoms, morpholino alkyl having 1-6 carbon atoms, mono alkyl amino alkyl wherein each alkyl moiety has 1-6 carbon atoms, dialkyl amino alkyl wherein each alkyl moiety has 1-6 carbon atoms.The said diphenylamine is usefully employed in a dye composition for dyeing keratinic fibers.

摘要翻译： 具有下式的二苯胺：其中R 1和R 4各自独立地表示选自氢，卤素，具有1-6个碳原子的低级烷基，具有1-6个碳原子的低级烷氧基，氨基， 其中烷基部分具有1-6个碳原子的N-低级烷基氨基，其中烷基部分具有1-6个碳原子的N-羟基烷基氨基，其中烷基部分具有1-6个碳原子的N-低级氨基甲酰基烷基氨基，酰基氨基 其中酰基部分具有2-7个碳原子，脲基和烷氧基氨基，其中烷氧基部分具有1-6个碳原子; R2和R3各自独立地表示选自氢，卤素，具有1-6个碳原子的低级烷基，具有1-6个碳原子的低级烷氧基，酰基氨基，其中酰基部分具有2-7个碳原子和脲基的成员; R 5和R 6各自独立地表示选自氢，卤素，具有1-6个碳原子的低级烷基和具有1-6个碳原子的低级烷氧基的成员，条件是当R 5和R 6至少不同于氢时， R5和R6之一占据了对-NHR7的位置; 并且R 7表示选自1-6个碳原子的烷基，具有1-6个碳原子的羟基烷基，具有1-6个碳原子的氨基烷基，酰基部分具有2-7个碳原子的酰基氨基烷基和 烷基部分具有1-6个碳原子，具有1-6个碳原子的甲磺酰氨基烷基，具有1-6个碳原子的氨基甲酰基烷基，具有1-6个碳原子的磺基烷基，具有1-6个碳原子的哌啶子基烷基，具有1个碳原子的吗啉代烷基 -6个碳原子，其中每个烷基部分具有1-6个碳原子的单烷基氨基烷基，其中每个烷基部分具有1-6个碳原子的二烷基氨基烷基。