公开(公告)号：US20130034210A1

公开(公告)日：2013-02-07

申请号：US13647873

申请日：2012-10-09

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： G01N23/04

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

摘要翻译： 能够悬浮活性剂的非水性单相载体。 非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。 所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯， 不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。 在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。 还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

公开(公告)号：US08252303B2

公开(公告)日：2012-08-28

申请号：US10295814

申请日：2002-11-14

申请人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

发明人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

IPC分类号： A61F2/00 ,  A61K47/30

CPC分类号： A61K38/1858 ,  A61K9/0002 ,  A61K9/0024 ,  A61K9/1617 ,  A61K31/445 ,  A61K38/27 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

摘要翻译： 提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物基本上改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

公开(公告)号：US20120122782A1

公开(公告)日：2012-05-17

申请号：US13301739

申请日：2011-11-21

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Zhongli Ding ,  Stephen Andrew Berry ,  Latha Pisharody Narayanan ,  Michael Desjardin

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Zhongli Ding ,  Stephen Andrew Berry ,  Latha Pisharody Narayanan ,  Michael Desjardin

IPC分类号： A61K38/27 ,  A61P5/06 ,  A61K38/02

CPC分类号： A61K47/32 ,  A61K9/0019 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1688 ,  A61K38/27 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K47/44

摘要： Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.

摘要翻译： 提供了制备和方法，用于提高暴露于存在于非水悬浮载体中的多肽的水性介质时的稳定性。 在本发明的特定方面，提供了包含悬浮在非水生物相容性悬浮载体中的金属离子和多肽的复合物的制剂。 当将水性介质引入这种制剂用于稳定多肽时，单个多肽分子的聚集被降低。

公开(公告)号：US20120100149A1

公开(公告)日：2012-04-26

申请号：US13282416

申请日：2011-10-26

申请人： Paul R. Houston ,  Guohua Chen ,  Andrew Sheung-King Luk

发明人： Paul R. Houston ,  Guohua Chen ,  Andrew Sheung-King Luk

IPC分类号： A61K39/395 ,  A61K47/34 ,  A61K31/7088 ,  A61K38/02 ,  A61K31/7052

CPC分类号： A61K47/44 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/19 ,  A61K38/385 ,  A61K38/47 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/94 ,  C12Y302/01017

摘要： An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

摘要翻译： 包含悬浮在单一成分载体中的至少一种治疗剂的可注射非水悬浮液。 单组分载体是单个两亲性材料，例如聚乙氧基化蓖麻油或其衍生物，聚氧乙烯烷基醚，聚氧乙烯山梨糖醇酐脂肪酸酯，聚氧乙烯硬脂酸酯，聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷的嵌段共聚物， 聚氧化丙烯 - 聚环氧乙烷 - 聚环氧丙烷的嵌段共聚物，聚氧化乙烯 - 聚氧化丙烯的四官能嵌段共聚物，或聚氧化丙烯 - 聚环氧乙烷的四官能嵌段共聚物。 还公开了包含可注射的非水悬浮液的剂量试剂盒和施用可注射的非水悬浮液的方法。

公开(公告)号：US20100011139A1

公开(公告)日：2010-01-14

申请号：US12442838

申请日：2007-05-09

申请人： Ju Wang ,  Shunlin Zhou ,  Rui Wang ,  Chi Fan ,  Haidong Wang ,  Guohua Chen ,  Shilin Zhang

发明人： Ju Wang ,  Shunlin Zhou ,  Rui Wang ,  Chi Fan ,  Haidong Wang ,  Guohua Chen ,  Shilin Zhang

IPC分类号： G06F13/00 ,  G06F15/16

CPC分类号： H04L45/14 ,  G06F13/4221 ,  H04L12/403 ,  H04L12/66

摘要： The present invention discloses a method for communication among different components, including integrating a Network Forwarding Component (NFC) for forwarding messages and at least one Independent Application Component (IAC) for performing other service processing into one network device; setting at least one cooperation mode in the NFC and each of the at least one IAC; and communicating with each other, by the NFC and the at least one IAC, according to the at least one cooperation mode. The cooperation mode may be any or any combination of a host mode, a mirror mode, a redirection mode and a pass-through mode. According to the present invention, the NFC and the IAC may communicate according to the cooperation mode so as to ensure that the NFC and the IAC can cooperate to provide various service capabilities including message forwarding and other additional service capabilities.

摘要翻译： 本发明公开了一种用于不同组件之间的通信的方法，包括将用于转发消息的网络转发组件（NFC）和至少一个独立应用组件（IAC）集成到一个网络设备中执行其他服务处理; 在NFC中设置至少一个协作模式和所述至少一个IAC中的每一个; 以及根据所述至少一个协作模式，通过所述NFC和所述至少一个IAC彼此进行通信。 协作模式可以是主机模式，镜像模式，重定向模式和直通模式的任何或任意组合。 根据本发明，NFC和IAC可以根据协作模式进行通信，以便确保NFC和IAC可以协作来提供包括消息转发和其他附加服务能力的各种服务能力。

公开(公告)号：US20090111934A1

公开(公告)日：2009-04-30

申请号：US12285372

申请日：2008-10-02

申请人： Caideng Yuan ,  Guohua Chen ,  Xixiang Zhang ,  Zongjin Li ,  Zhimeng Liu

发明人： Caideng Yuan ,  Guohua Chen ,  Xixiang Zhang ,  Zongjin Li ,  Zhimeng Liu

IPC分类号： C08G18/32

CPC分类号： C08G18/6254 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/6692 ,  C08G18/675 ,  C08G18/755 ,  C08G18/7621 ,  C08G2270/00 ,  C09D175/04 ,  C08G18/3228 ,  C08G18/62

摘要： A novel method for the preparation of an aqueous polyacrylate modified polyurethane dispersion is disclosed. The preparation method includes three main steps: a) preparation of polyacrylate polymer or copolymer emulsion; b) preparation of polyurethane prepolymer with carboxylic groups and neutralization treatment to the carboxylic groups; and c) dispersion and chain-extension of polyurethane prepolymer by adding the polyacrylate emulsion into the polyurethane prepolymer under vigorous agitation, or other mechanical operation. The aqueous polyacrylate modified polyurethane dispersion has self-crosslinkability when an unsaturated acetoacetoxy compound is used for the preparation of the polyacrylate emulsion.

摘要翻译： 公开了一种制备聚丙烯酸酯改性聚氨酯水分散体的新方法。 制备方法包括三个主要步骤：a）制备聚丙烯酸酯聚合物或共聚物乳液; b）制备具有羧基的聚氨酯预聚物，并对羧基进行中和处理; 和c）通过在剧烈搅拌或其它机械操作下将聚丙烯酸酯乳液加入聚氨酯预聚物中，聚氨酯预聚物的分散和链延长。 当不饱和乙酰乙酰氧基化合物用于制备聚丙烯酸酯乳液时，聚丙烯酸酯改性聚氨酯分散体具有自交联性。

公开(公告)号：US07241457B2

公开(公告)日：2007-07-10

申请号：US10953895

申请日：2004-09-29

申请人： Guohua Chen ,  Rupal A. Ayer ,  Scott Lautenbach

发明人： Guohua Chen ,  Rupal A. Ayer ,  Scott Lautenbach

IPC分类号： A61K9/22

CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M5/145 ,  A61M2005/14513

摘要： In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.

摘要翻译： 一方面，本发明涉及一种渗透泵，其随着渗透泵在操作环境中的功能而自动提供活性剂的上升释放速率，并且可被设计用于植入期望的动物或人类受试者内。 根据本发明的渗透泵包括储存器，速率控制膜，可膨胀渗透组合物，活性剂制剂和出口孔。 一旦施用于操作环境，水通过速率控制膜并进入渗透组合物，其导致渗透组合物通过出口孔膨胀并排出活性剂制剂，速率与其速率成正比 水通过速率控制膜。 根据本发明的渗透泵允许通过速率控制膜的水流自动增加，而不需要在给药后操纵渗透泵。 随着通过速率控制膜的水流量增加，活性剂从渗透泵输送的速率也将成比例地增加。

公开(公告)号：US20070077304A1

公开(公告)日：2007-04-05

申请号：US11535398

申请日：2006-09-26

申请人： Andrew Luk ,  Gunjan Junnarkar ,  Guohua Chen

发明人： Andrew Luk ,  Gunjan Junnarkar ,  Guohua Chen

IPC分类号： A61K9/14

CPC分类号： A61K31/519 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1617 ,  A61K9/1647 ,  A61K31/341 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/34 ,  A61K51/1213

摘要： An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.

摘要翻译： 可注射的贮库制剂包括生物相容性聚合物，与生物相容性聚合物结合以形成粘性凝胶的有机溶剂和掺入粘性凝胶中的小分子药物，使得制剂表现出体内释放曲线，其具有C max / SUB>至C 比小于200，滞后时间小于0.2。

公开(公告)号：US20050281879A1

公开(公告)日：2005-12-22

申请号：US10985116

申请日：2004-11-10

申请人： Guohua Chen ,  David Priebe

发明人： Guohua Chen ,  David Priebe

IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K9/14

CPC分类号： A61K9/0024 ,  A61K31/445 ,  A61K38/27 ,  A61K47/34

摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

摘要翻译： 提供了提供用于调节释放速率和稳定有益剂的赋形剂的可注射贮库凝胶组合物和试剂盒。 还提供了施用和制备这种体系的方法。 凝胶组合物包含可生物降解的，可生物腐蚀的聚合物和与水不混溶的溶剂，其量有效地使聚合物增塑并与聚合物形成凝胶。 合适的赋形剂包括pH调节剂，还原剂和抗氧化剂。

公开(公告)号：US20050281877A1

公开(公告)日：2005-12-22

申请号：US11196758

申请日：2005-08-02

申请人： Guohua Chen ,  Scott Lautenbach ,  Keith Dionne ,  Scott Jordan ,  Steve Berry ,  Craig Rodenberger ,  Rupal Ayer

发明人： Guohua Chen ,  Scott Lautenbach ,  Keith Dionne ,  Scott Jordan ,  Steve Berry ,  Craig Rodenberger ,  Rupal Ayer

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/52

CPC分类号： A61K9/0004

摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

摘要翻译： 提供了渗透输送系统半透性体组件，其从包含半透性体组件的渗透输送系统控制有益剂的输送速率。 半透性体组件或塞子包括半渗透体，其可定位在渗透递送系统的开口中。 半透明体具有中空的内部部分，其具有选择的尺寸以获得通过半透性体的预定液体渗透速率。 由于渗透输送系统中的有益剂以基本上相同的速率递送，所以渗透剂吸收从周围环境透过塞子的液体，并且通过塞子的液体渗透速率控制有益剂的输送速率 渗透输送系统。 可以改变通过半透性体的液体渗透速率，以通过改变半透性体的厚度或通过改变暴露于液体的半透明体的表面积的量来控制有益剂从渗透递送系统的输送速率， 渗透输送系统位于使用的液体环境中。