摘要:
A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要:
The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要:
A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
摘要:
A method for improving the sound quality of voice signals transmitted during a call between two digital wireless telephones by diverting the call from a circuit switched network to a data network is disclosed. In accordance with the present invention, a call setup procedure using the circuit switched network is modified so that the calling party may determine the following information: I) whether the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and 2) whether both wireless telephones have access to the same data network. If the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and both wireless telephones have access to the same data network, the circuit switched network call setup procedure is abandoned before the called party answers the call and the call is completed using the data network. Completing the call by encoding voice signals using a common voice compression algorithm executed by the digital wireless telephones and by sending the encoded voice signals through a data network eliminates the drawbacks associated with the additional intermediate encoding which would have been required if the call had been completed using the circuit switched network.
摘要:
Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Vancomycin-polymer conjugates made by the methods and methods of treatment using the conjugates are also disclosed.
摘要:
The present invention provides polymeric linkers containing branching moieties. Methods of making the polymeric linkers and methods of making conjugates using the same are also disclosed.
摘要:
Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is Methods of making and using the compounds and conjugates described herein are also provided.
摘要:
A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要:
A new method of preparing a tertiary alkyl ester of a polyalkylene oxide is provided. The new method employs milder conditions that avoid the back reaction to the starting polyalkylene oxide. The tertiary alkyl ester of a polyalkylene oxide is then reacted with a suitable acid to produce a polyalkylene oxide acid.
摘要:
Disclosed is an improved approach for performing crosstalk and signal integrity analysis in which multiple variables are taken into account when analyzing the effects of on-chip crosstalk, such as for example coupled wire length, ration of coupling capacitance, and aggressor and victim driver types. Rather than performing a full-chip simulation, the potential crosstalk effects can be pre-characterized by performing simulation/modeling over specific net portions by systematically changing the values of these multiple variables. A set of patterns characterized from the variables are formed from the modeling. During the analysis process, the IC design is checked of the presence of the patterns, from which is produced the expected delay impact for crosstalk in the design.