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336 条记录 (耗时 0.045 秒)

    Human pancreatitis-associated protein
    63.
    发明授权
    Human pancreatitis-associated protein 失效
    人胰腺炎相关蛋白

    公开(公告)号：US06492499B1

    公开(公告)日：2002-12-10

    申请号：US09226852

    申请日：1999-01-07

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C07K100

    CPC分类号： C07K14/4733 ,  A61K38/00

    摘要： The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provides methods for treating or preventing diseases associated with expression of human PAP-2.

    摘要翻译： 本发明提供了一种鉴定和编码人PAP-2的新型人C型凝集素（人PAP-2）和多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体或拮抗剂。 本发明还提供了治疗或预防与人PAP-2表达相关的疾病的方法。

    Human LEA-motif developmental protein
    65.
    发明授权
    Human LEA-motif developmental protein 失效
    人类LEA主题发育蛋白

    公开(公告)号：US06281190B1

    公开(公告)日：2001-08-28

    申请号：US09213391

    申请日：1998-12-15

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C07K1400

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The present invention provides a human LEA motif protein (HuLEAP) and polynucleotides which identify and encode HuLEAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HuLEAP and a method for producing HuLEAP. The invention also provides for agonists, antibodies, or antagonists specifically binding HuLEAP, and their use, in the prevention and treatment of diseases associated with expression of HuLEAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HuLEAP for the treatment of diseases associated with the expression of HuLEAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HuLEAP.

    摘要翻译： 本发明提供了人LEA基序蛋白（HuLEAP）和识别和编码HuLEAP的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HuLEAP的核酸序列和生产HuLEAP的方法。 本发明还提供了特异性结合HuLEAP的激动剂，抗体或拮抗剂及其在预防和治疗与HuLEAP表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码HuLEAP的多核苷酸用于治疗与HuLEAP表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合HuLEAP的抗体的诊断测定法。

    Microtubule-associated protein
    66.
    发明授权
    Microtubule-associated protein 失效
    微管相关蛋白

    公开(公告)号：US06280733B1

    公开(公告)日：2001-08-28

    申请号：US09199838

    申请日：1998-11-24

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K3900

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human microtubule-associated protein (hLC3) and the polynucleotides which identify and encode hLC3. The invention also provides genetically engineered expression vectors, host cells, and a method for producing hLC3. The invention also provides hLC3 as well as agonists, antibodies, and antagonists of hLC3, and the use thereof for the prevention and treatment of diseases associated with the expression of hLC3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding hLC3 for the treatment of diseases associated with the expression of hLC3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding hLC3.

    摘要翻译： 本发明提供了人微管相关蛋白（hLC3）和识别和编码hLC3的多核苷酸。 本发明还提供基因工程表达载体，宿主细胞和生产hLC3的方法。 本发明还提供hLC3以及hLC3的激动剂，抗体和拮抗剂，以及其用于预防和治疗与hLC3表达有关的疾病的用途。 另外，本发明提供了将反义分子用于编码hLC3的多核苷酸用于治疗与hLC3表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合hLC3的抗体的诊断测定法。

    Protein phosphatase regulatory subunit
    67.
    发明授权
    Protein phosphatase regulatory subunit 失效
    蛋白磷酸酶调节亚基

    公开(公告)号：US6093565A

    公开(公告)日：2000-07-25

    申请号：US764563

    申请日：1996-12-12

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C12N1/21 ,  C12N9/16 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The present invention provides a human protein phosphatase regulatory subunit (HCNB) and polynucleotides which identify and encode HCNB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCNB and a method for producing HCNB. The invention also provides for agonists, antibodies, or antagonists specifically binding HCNB, and their use, in the prevention and treatment of diseases associated with expression of HCNB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCNB for the treatment of diseases associated with the expression of HCNB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCNB.

    摘要翻译： 本发明提供了人类蛋白磷酸酶调控亚基（HCNB）和识别和编码HCNB的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HCNB的核酸序列和生产HCNB的方法。 本发明还提供特异性结合HCNB的激动剂，抗体或拮抗剂及其在预防和治疗与HCNB表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码HCNB的多核苷酸用于治疗与HCNB表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HCNB的抗体的诊断测定法。

    Disease associated acidic protein
    68.
    发明授权
    Disease associated acidic protein 失效
    疾病相关酸性蛋白

    公开(公告)号：US6090577A

    公开(公告)日：2000-07-18

    申请号：US859937

    申请日：1997-05-22

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides a human disease associated acidic protein and polynucleotides which identify and encode DAAP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DAAP.

    摘要翻译： 本发明提供了一种人类疾病相关的酸性蛋白质和鉴定和编码DAAP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与DAAP表达相关的疾病的方法。

    Human proton atpase subunit
    69.
    发明授权
    Human proton atpase subunit 失效
    人质子atpase亚基

    公开(公告)号：US6010852A

    公开(公告)日：2000-01-04

    申请号：US807300

    申请日：1997-02-27

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12N9/14 ,  C12Q1/68 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C12N9/14

    摘要： The present invention provides a human proton ATPase subunit (HPAS) and polynucleotides which encode HPAS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HPAS.

    摘要翻译： 本发明提供人质子ATP酶亚基（HPAS）和编码HPAS的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。 本发明还提供了治疗与HPAS表达相关的疾病的方法。

    Human selenoprotein
    70.
    发明授权
    Human selenoprotein 失效
    人类硒蛋白

    公开(公告)号：US05998371A

    公开(公告)日：1999-12-07

    申请号：US127289

    申请日：1998-07-13

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/17 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human selenoprotein (HSEL) and polynucleotides which identify and encode HSEL. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEL and a method for producing HSEL. The invention also provides for agonists, antibodies, or antagonists specifically binding HSEL, and their use, in the prevention and treatment of diseases associated with expression of HSEL. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEL for the treatment of diseases associated with the expression of HSEL. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEL.

    摘要翻译： 本发明提供鉴定和编码HSEL的人类硒蛋白（HSEL）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSEL的核酸序列和生产HSEL的方法。 本发明还提供特异性结合HSEL的激动剂，抗体或拮抗剂及其在预防和治疗与HSEL表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码HSEL的多核苷酸用于治疗与HSEL表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HSEL的抗体的诊断测定法。