公开(公告)号：US5948638A

公开(公告)日：1999-09-07

申请号：US839031

申请日：1997-04-23

申请人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

发明人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P29/00 ,  C07K14/47 ,  C07K14/715 ,  C07K16/24 ,  C12N1/19 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12N15/10

CPC分类号： C07K14/4743 ,  C07K14/47 ,  C07K16/24 ,  A61K38/00 ,  C07K2317/34

摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

公开(公告)号：US5843675A

公开(公告)日：1998-12-01

申请号：US602228

申请日：1996-02-15

申请人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

发明人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P29/00 ,  C07K14/47 ,  C07K14/715 ,  C07K16/24 ,  C12N1/19 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  G01N33/53 ,  C07K14/705

CPC分类号： C07K14/4743 ,  C07K14/47 ,  C07K16/24 ,  A61K38/00 ,  C07K2317/34

摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

公开(公告)号：US4123197A

公开(公告)日：1978-10-31

申请号：US765764

申请日：1977-02-04

申请人： Phillip W. Keem ,  Laimons Kaimins ,  James Graham

发明人： Phillip W. Keem ,  Laimons Kaimins ,  James Graham

IPC分类号： F04D25/10 ,  F16D7/02 ,  F16D7/00 ,  F16D63/00

CPC分类号： F16D7/022 ,  F04D25/10

摘要： A clutch mechanism suitable for connecting a rotatable member to an output shaft of a motor, which mechanism comprises a body which is attachable to the output shaft and a resilient arm, one end of which is fixed to the body the other end of which is capable of engaging the rotatable member or part thereof, wherein the body is capable of gripping the output shaft in secure frictional contact to transfer rotational drive from the output shaft to the rotatable member only when the rotatable member is not restrained against rotation.

摘要翻译： 一种适于将可旋转构件连接到电动机的输出轴的离合器机构，该机构包括可连接到输出轴的主体和弹性臂，弹性臂的一端固定到主体的另一端，该主体的另一端能够 使可旋转构件或其一部分接合，其中主体能够以可靠的摩擦接触来夹持输出轴，以便仅当可旋转构件不受阻止旋转时才将旋转驱动从输出轴传递到可旋转构件。