摘要:
Compounds of Formula I ##STR1## wherein the bond is a single bond or a double bond,X is hydrogen, fluorine, chlorine, or bromine,R.sub.1 is formyl, alkanoyl or alkoxyalkyl each of which contains 2-8 carbon atoms, or benzoyl, andY is chlorine, hydroxy, formyl, alkanoyloxy of 2-8 carbon atoms, or benzoyloxy,have valuable anti-inflammatory properties.
摘要:
17.alpha.-Alkyl-17.beta.-hydroxy-1.alpha.-methyl-4-androsten-3-ones of the formula ##STR1## wherein R is a straight-chain alkyl residue of 3-8 carbon atoms, i.e., C.sub.3-8 -n-alkyl, are pharmacologically active compounds distinguished by antiandrogenic activity, especially upon topical application.
摘要:
6.alpha.-Methyl corticoids of formula I ##STR1## wherein is a single bond or a double bond, R is acyloxy of up to 8 carbon atoms, and X is chlorine, hydroxy, or acyloxy of up to 8 carbon atoms, are pharamacologically effective substances.
摘要:
6.alpha.-Methylprednisolone derivatives of Formula I ##STR1## wherein R.sub.1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl andR.sub.2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious compounds, e.g., as antiinflammatories.
摘要:
17-haloethynyl steroids of the partial formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate,X is bromine or iodine, andV is methylene, ethylene, vinylene, ethylidene, vinylidene or cyclopropylene,can be prepared by treating an ethynyl steroid of the partial formula ##STR2## wherein R.sub.1, R.sub.2, and V are as defined above, in an inert solvent with a brominating agent or an iodinating agent in the presence of a silver salt. Certain new compounds are also provided.
摘要:
A process for preparing 6-methyl-.DELTA..sup.4,6 -3-keto steroids of the formula ##STR1## comprises reacting a corresponding .DELTA..sup.4 -3-keto steroid with methoxymethyl acetate (CH.sub.3 --O--CH.sub.2 --OAc) in an inert solvent at temperatures above room temperature in the presence of an alkali metal acetate.
摘要:
Corticoid 21-sulfopropionates of the formula ##STR1## wherein St is a steroid nucleus of a corticoid having anti-inflammatory activity,and the salts thereof with physiologically acceptable bases, simultaneously form stable, sterilizable and storable solutions and also are very rapidly cleaved after i.v. administration, yielding the free corticoids as the cleavage product.
摘要:
Corticoids of the formula ##STR1## wherein X is .beta.-hydroxymethylene or carbonyl, and 21-esters thereof with physiologically acceptable acids possess topical anti-inflammatory activity with relatively little systemic activity.
摘要:
11.beta.-Fluoroandrostenes of the formula ##SPC1##Wherein R.sub.1 and R.sub.2 are hydrogen atoms, methylene or another C--C bond; R.sub.3 is H or Cl, R.sub.4 is H, F or Cl; and X is carbonyl, .beta.-hydroxymethylene, or an ester or ether thereof or .alpha.-alkyl-.beta.-hydroxymethylene or an ester thereof, possess androgenic activity and can be prepared by the dehalogenation of a corresponding 9.alpha.-halo-11.beta.-F steroid.
摘要:
8.alpha.-Estratrienes of the formula ##SPC1##Wherein R is lower alkyl and X is an oxygen atom, a .beta.-hydroxy or .beta.-hydroxy-.alpha.-substituted or unsubstituted saturated or unsaturated hydrocarbon group, and the esters and ethers thereof, possess strong vaginotropic but only weak utertropic activity and are useful in the treatment of estrogenic deficiency conditions where uteral effects are not desired.