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110 条记录 (耗时 0.056 秒)

    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
    64.
    发明授权
    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane 有权
    2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷的抗病毒活性和拆分

    公开(公告)号：US07402588B2

    公开(公告)日：2008-07-22

    申请号：US11390861

    申请日：2006-03-28

    申请人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    发明人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    IPC分类号： A61K31/506 ,  C07D411/04

    CPC分类号： C07D327/04 ,  A61K31/513 ,  C07D405/04 ,  C07D411/04 ,  C07H19/06 ,  C07H19/10 ,  Y10S514/885

    摘要： A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.

    摘要翻译： 公开了用于治疗人体中HIV和HBV感染的方法和组合物，其包括给予有效量的2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷，其药学上可接受的衍生物 ，包括在药学上可接受的载体中的5'或N 4 S 4烷基化或酰化衍生物或其药学上可接受的盐。 还公开了一种用于拆分核苷对映异构体外消旋混合物的方法，其包括将外消旋混合物暴露于优先催化其中一种对映异构体中的反应的酶的步骤。

    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
    67.
    发明授权
    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane 失效
    2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷的抗病毒活性和拆分

    公开(公告)号：US06642245B1

    公开(公告)日：2003-11-04

    申请号：US08475339

    申请日：1995-06-07

    申请人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    发明人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    IPC分类号： A61K31506

    CPC分类号： C07D327/04 ,  A61K31/513 ,  C07D405/04 ,  C07D411/04 ,  C07H19/06 ,  C07H19/10 ,  Y10S514/885

    摘要： A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.

    摘要翻译： 公开了用于治疗人体中HIV和HBV感染的方法和组合物，其包括给予有效量的2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷，其药学上可接受的衍生物 包括在药学上可接受的载体中包括5'或N 4烷基化或酰化衍生物或其药学上可接受的盐。还公开了用于拆分核苷对映异构体外消旋混合物的方法，其包括将 外消旋混合物到优先催化其中一种对映异构体中的反应的酶。

    [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
    69.
    发明授权
    [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides 失效
    [5-羧甲酰氨基或5-氟] - [2'，3'-不饱和或3'-修饰] - 嘧啶核苷

    公开(公告)号：US06391859B1

    公开(公告)日：2002-05-21

    申请号：US09677161

    申请日：2000-10-02

    申请人： Raymond F. Schinazi ,  Dennis C. Liotta

    发明人： Raymond F. Schinazi ,  Dennis C. Liotta

    IPC分类号： A01N4304

    CPC分类号： A61K31/7068 ,  A61K31/70 ,  A61K45/06 ,  C07H19/06 ,  A61K2300/00

    摘要： A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于治疗人和其他宿主动物中的HIV和HBV感染的方法和组合物，其包括给予有效量的[5-甲酰氨基或5-氟] -2'，3'-二脱氧-2' ，3'-二脱氢嘧啶核苷或[5-甲酰氨基或5-氟] -3'-修饰的嘧啶核苷或其混合物或药学上可接受的衍生物，包括5'或N4烷基化或酰化衍生物，或 其药学上可接受的盐在药学上可接受的载体中。