利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.02 秒)

    2′-Fluoronucleosides
    1.
    发明授权
    2′-Fluoronucleosides 有权
    2'-氟核苷

    公开(公告)号：US07307065B2

    公开(公告)日：2007-12-11

    申请号：US10796529

    申请日：2004-03-08

    申请人： Raymond F. Schinazi ,  Dennis C. Liotta ,  Chung K. Chu ,  J. Jeffrey McAtee ,  Junxing Shi ,  Yongseok Choi ,  Kyeong Lee ,  Joon H. Hong

    发明人： Raymond F. Schinazi ,  Dennis C. Liotta ,  Chung K. Chu ,  J. Jeffrey McAtee ,  Junxing Shi ,  Yongseok Choi ,  Kyeong Lee ,  Joon H. Hong

    IPC分类号： A61K38/00 ,  A01N61/00 ,  C07H1/00 ,  C07G3/00

    CPC分类号： A61K31/7076 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708 ,  C07D405/04 ,  C07D473/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16

    摘要： A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base; R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 公开了一类可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。 所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，包括F或CF 3 N ，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基，碱是指嘌呤或嘧啶碱基; R 2是H，磷酸盐，包括单磷酸盐，二磷酸盐，三磷酸盐或稳定化的磷酸盐前药; 酰基或其它药学上可接受的离去基团，其当在体内施用时能够提供其中R 2是H或磷酸酯的化合物; 磺酸酯，包括烷基或芳基烷基磺酰基，包括甲磺酰基，苄基，其中苯基任选被一个或多个取代基取代，如上述芳基定义中所述，脂质，氨基酸，肽或胆固醇; 并且R 3是酰基，烷基，磷酸酯或其它药学上可接受的离去基团，当其在体内施用时，其能够被切割成母体化合物或其药学上可接受的盐。

    BATTERY PACK PROVIDING IMPROVED DISTRIBUTION UNIFORMITY OF COOLANT
    4.
    发明申请
    BATTERY PACK PROVIDING IMPROVED DISTRIBUTION UNIFORMITY OF COOLANT 有权
    电池组提供改进的冷却剂分配均匀性

    公开(公告)号：US20130280566A1

    公开(公告)日：2013-10-24

    申请号：US13878522

    申请日：2011-11-02

    申请人： Chae Ho Chung ,  Ye Hoon Im ,  WonChan Park ,  DalMo Kang ,  YongSeok Choi

    发明人： Chae Ho Chung ,  Ye Hoon Im ,  WonChan Park ,  DalMo Kang ,  YongSeok Choi

    IPC分类号： H01M10/50

    CPC分类号： H01M10/5004 ,  H01M2/1077 ,  H01M2/1083 ,  H01M2/206 ,  H01M10/613 ,  H01M10/625 ,  H01M10/6557

    摘要： Disclosed herein is a battery pack having a plurality of battery cells or unit modules (‘unit cells’) electrically connected to each other, wherein the unit cells are arranged in a width direction (traverse direction) of the battery pack in an upright fashion in a state in which the unit cells are spaced apart from each other to form coolant flow channels, thereby constituting a battery module layer, and two or more battery module layers are mounted in a pack case such that the battery module layers are stacked in a height direction (vertical direction) of the battery pack, and wherein the battery pack includes a coolant introduction part, through which a coolant is introduced into the two or more battery module layers to simultaneously cool some or all of the unit cells in the two or more battery module layers, and a coolant discharge part, through which the coolant, having passed the unit cells, is discharged.

    摘要翻译： 这里公开了具有彼此电连接的多个电池单元或单元模块（“单元电池”）的电池组，其中单元电池以直立方式布置在电池组的宽度方向（横向）上 其中单元电池彼此间隔开以形成冷却剂流动通道的状态，由此构成电池模块层，并且两个或更多个电池模块层安装在包装盒中，使得电池模块层以高度堆叠 电池组的方向（垂直方向），并且其中电池组包括冷却剂引入部分，通过该冷却剂引入部分将冷却剂引入到两个或更多个电池模块层中，以同时冷却两个或更多个中的单元电池中的一些或全部 电池模块层和冷却剂排出部分，通过该冷却剂排放部分已经通过单电池的冷却剂被排出。

    Memory system and method of managing a memory system
    8.
    发明申请
    Memory system and method of managing a memory system 审中-公开
    存储器系统和管理存储器系统的方法

    公开(公告)号：US20050081002A1

    公开(公告)日：2005-04-14

    申请号：US10962406

    申请日：2004-10-13

    申请人： Naehyuck Chang ,  Hojun Shim ,  Yongsoo Joo ,  Yongseok Choi ,  Hyung Lee

    发明人： Naehyuck Chang ,  Hojun Shim ,  Yongsoo Joo ,  Yongseok Choi ,  Hyung Lee

    IPC分类号： G11C5/14 ,  G06F1/32 ,  G06F12/00

    CPC分类号： G06F1/3275 ,  G06F1/3225 ,  Y02D10/14

    摘要： A method to reduce consumption of static and dynamic energy in a memory system. The method efficiently reduces dynamic and static energy consumed by the memory system by analyzing factors including characteristics of application programs, hardware performance, and the state of memory address buses, which may affect energy consumption, and by controlling a memory device based on the analysis.

    摘要翻译： 一种减少存储系统中静态和动态能量消耗的方法。 该方法通过分析包括应用程序的特性，硬件性能以及可能影响能量消耗的存储器地址总线的状态以及基于分析来控制存储器件的因素，来有效地降低存储器系统消耗的动态和静态能量。

    Battery pack providing improved distribution uniformity of coolant
    9.
    发明授权
    Battery pack providing improved distribution uniformity of coolant 有权
    电池组提供了改善的冷却剂分配均匀性

    公开(公告)号：US09203124B2

    公开(公告)日：2015-12-01

    申请号：US13878522

    申请日：2011-11-02

    申请人： Chae Ho Chung ,  Ye Hoon Im ,  WonChan Park ,  DalMo Kang ,  YongSeok Choi

    发明人： Chae Ho Chung ,  Ye Hoon Im ,  WonChan Park ,  DalMo Kang ,  YongSeok Choi

    IPC分类号： H01M10/50 ,  H01M10/613 ,  H01M2/10 ,  H01M2/20 ,  H01M10/625 ,  H01M10/6557

    CPC分类号： H01M10/5004 ,  H01M2/1077 ,  H01M2/1083 ,  H01M2/206 ,  H01M10/613 ,  H01M10/625 ,  H01M10/6557

    摘要： Disclosed herein is a battery pack having a plurality of battery cells or unit modules (‘unit cells’) electrically connected to each other, wherein the unit cells are arranged in a width direction (traverse direction) of the battery pack in an upright fashion in a state in which the unit cells are spaced apart from each other to form coolant flow channels, thereby constituting a battery module layer, and two or more battery module layers are mounted in a pack case such that the battery module layers are stacked in a height direction (vertical direction) of the battery pack, and wherein the battery pack includes a coolant introduction part, through which a coolant is introduced into the two or more battery module layers to simultaneously cool some or all of the unit cells in the two or more battery module layers, and a coolant discharge part, through which the coolant, having passed the unit cells, is discharged.

    摘要翻译： 这里公开了具有彼此电连接的多个电池单元或单元模块（“单元电池”）的电池组，其中单元电池以直立方式布置在电池组的宽度方向（横向）上 其中单元电池彼此间隔开以形成冷却剂流动通道的状态，由此构成电池模块层，并且两个或更多个电池模块层安装在包装盒中，使得电池模块层以高度堆叠 电池组的方向（垂直方向），并且其中电池组包括冷却剂引入部分，通过该冷却剂引入部分将冷却剂引入到两个或更多个电池模块层中，以同时冷却两个或更多个中的单元电池中的一些或全部 电池模块层和冷却剂排出部分，通过该冷却剂排放部分已经通过单电池的冷却剂被排出。