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    Metabolically stable puromycin analogs
    3.
    发明授权
    Metabolically stable puromycin analogs 有权
    代谢稳定的嘌呤霉素类似物

    公开(公告)号：US07897759B2

    公开(公告)日：2011-03-01

    申请号：US12164900

    申请日：2008-06-30

    申请人： Giuseppe Gumina ,  Roger L. White

    发明人： Giuseppe Gumina ,  Roger L. White

    IPC分类号： C07H19/00 ,  C07H19/22

    CPC分类号： C07H19/16

    摘要： Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure further relates to pharmaceutical compositions comprising one or more disclosed modified nucleosides and to methods of use thereof.

    摘要翻译： 公开了具有抗肿瘤活性的结构修饰的，代谢稳定的核苷，其中有毒代谢物的形成被阻断和抗微生物活性。 本公开还涉及包含一种或多种公开的修饰核苷的药物组合物及其使用方法。

    L-nucleosides as ligands to adenosine receptors
    4.
    发明授权
    L-nucleosides as ligands to adenosine receptors 失效
    L-核苷作为腺苷受体的配体

    公开(公告)号：US07423025B2

    公开(公告)日：2008-09-09

    申请号：US11517977

    申请日：2006-09-08

    申请人： Giuseppe Gumina ,  Craig C. Beeson ,  Gary L. Wright

    发明人： Giuseppe Gumina ,  Craig C. Beeson ,  Gary L. Wright

    IPC分类号： A61K31/70 ,  C07H19/16

    CPC分类号： A61K31/7076

    摘要： Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries; and neurodegenerative diseases. The compounds disclosed herein have the formula: wherein R1 and R2 are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl; R3 is branched or straight-chain, substituted or unsubstituted alkyl, hydroxy-alkyl, or —C(═O)NR6R7; and R4 and R5 are, independently, H, hydroxy, halogen, and NR8R9, wherein R6, R7, R8, and R9 are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl.

    摘要翻译： 本文公开了具有式I的化合物，其是非天然L-腺苷类似物。 还公开了它们的制造方法。 更进一步地，公开了所公开的化合物用于治疗心血管疾病，缺血相关损伤的用途; 和神经变性疾病。 本文公开的化合物具有下式：其中R 1和R 2独立地为H，支链或直链，取代或未取代的烷基，烯基，炔基或 芳基; R 3是支链或直链，取代或未取代的烷基，羟基 - 烷基或-C（-O）NR 6 R 7， ; R 4和R 5独立地是H，羟基，卤素和NR 8 R 9， 其中R 6，R 7，R 8和R 9独立地为H，支链或直链 链，取代或未取代的烷基，烯基，炔基或芳基。

    L-nucleosides as ligands to adenosine receptors
    5.
    发明申请
    L-nucleosides as ligands to adenosine receptors 失效
    L-核苷作为腺苷受体的配体

    公开(公告)号：US20070054875A1

    公开(公告)日：2007-03-08

    申请号：US11517977

    申请日：2006-09-08

    申请人： Giuseppe Gumina ,  Craig Beeson ,  Gary Wright

    发明人： Giuseppe Gumina ,  Craig Beeson ,  Gary Wright

    IPC分类号： A61K31/7076

    CPC分类号： A61K31/7076

    摘要： Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries, and neurodegenerative diseases.

    摘要翻译： 本文公开了具有式I的化合物，其是非天然L-腺苷类似物。 还公开了它们的制造方法。 更进一步地，公开了所公开的化合物用于治疗心血管疾病，缺血相关损伤和神经变性疾病的用途。