公开(公告)号：US20130244235A1

公开(公告)日：2013-09-19

申请号：US13773791

申请日：2013-02-22

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  Tracy C. Yab ,  John B. Kisiel

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasia (CRN) associated with inflammatory bowel disease (IBD). The present invention provides markers specific for colorectal neoplasia associated with inflammatory bowel disease in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having colorectal neoplasia associated with inflammatory bowel disease by detecting the presence and level of indicators of colorectal neoplasia such as, for example, epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of BMP3, NDRG4, vimentin, EYA4) in DNA from a stool sample obtained from the mammal.

Abstract translation: 本发明提供与检测与炎性肠病（IBD）相关的结肠直肠肿瘤（CRN）相关的方法和材料。 本发明提供了与受试者粪便样品中或与其相关的炎症性肠病相关的结肠直肠肿瘤特异性标志物。 特别地，本发明提供了用于通过检测结肠直肠瘤形成指标的存在和水平（例如表观遗传学改变）（例如DNA甲基化）来鉴定具有与炎症性肠病相关的结肠直肠肿瘤的哺乳动物（例如，人）的方法和材料 ）（例如，CpG甲基化）（例如，BMP3，NDRG4，波形蛋白，EYA4的编码区或调节区中的CpG甲基化）来自哺乳动物的粪便样品。

公开(公告)号：US20240182980A1

公开(公告)日：2024-06-06

申请号：US18489096

申请日：2023-10-18

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

公开(公告)号：US20240110245A1

公开(公告)日：2024-04-04

申请号：US18241411

申请日：2023-09-01

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: The present disclosure relates to detecting one or more types of gynecological cancer in a biological sample from a subject. In particular, the present disclosure provides compositions and methods for detecting the presence or absence of one or more types of gynecological cancer (e.g., cervical cancer, ovarian cancer, endometrial cancer) in a biological sample from a subject having or suspected of having a gynecological cancer.

公开(公告)号：US20230272482A1

公开(公告)日：2023-08-31

申请号：US18062419

申请日：2022-12-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  C12Y302/01001 ,  C12Y304/2107 ,  C12Q2600/156 ,  C12Q2600/154 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00 ,  C12Q2600/158

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20230212691A1

公开(公告)日：2023-07-06

申请号：US18069550

申请日：2022-12-21

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.

公开(公告)号：US20220403471A1

公开(公告)日：2022-12-22

申请号：US17638840

申请日：2020-08-27

Applicant: Exact Sciences Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： Scott Morris ,  David Mallery ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Maria Giakoumopoulos ,  Michael W. Kaiser ,  David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney

IPC: C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as lung cancer.

公开(公告)号：US11384401B2

公开(公告)日：2022-07-12

申请号：US16908056

申请日：2020-06-22

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

公开(公告)号：US11078543B2

公开(公告)日：2021-08-03

申请号：US16093534

申请日：2017-04-13

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6886

Abstract: Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).

公开(公告)号：US11047013B2

公开(公告)日：2021-06-29

申请号：US16093534

申请日：2017-04-13

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6886

Abstract: Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).

公开(公告)号：US20210095350A1

公开(公告)日：2021-04-01

申请号：US17101904

申请日：2020-11-23

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6858 ,  C12Q1/6827

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.