公开(公告)号：US07488732B2

公开(公告)日：2009-02-10

申请号：US10549936

申请日：2004-03-30

申请人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Oliver Wagner ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

发明人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Oliver Wagner ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

IPC分类号： C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D239/46 ,  A01N43/54

CPC分类号： A01N43/54 ,  C07D239/28 ,  C07D239/30

摘要： 2-Substituted pyrimidines of the formula I in which the index n and the substituents L, Ra, Rb, Rc, Rz, Ru, Rv, A′, A″ and A′″ are as defined in the description and: R1 is C3-C10-alkyl, C3-C10-alkenyl, C3-C10-alkynyl, C3-C12-cycloalkyl, C3-C10-cycloalkenyl or a five- to ten-membered saturated, partially unsaturated or aromatic heterocycle which is attached via carbon and contains one to four heteroatoms from the group consisting of O, N and S, R2 is halogen, cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-alkoxy, C3-C4-alkenyloxy or C3-C4-alkynyloxy, where the alkyl, alkenyl and alkynyl radicals of R2 may be substituted by halogen, cyano, nitro, C1-C2-alkoxy or C1-C4-alkoxycarbonyl, and R3 is cyano, CO2Ra, C(═O)NRzRb, C(═O)—N—ORb, C(═S)—NRaRb, C(═NORa)NRzRb, C(═NRa)NRzRb, C(═O)NRa—NRzRb, C(═N—NRzRc)NRaRb, C(═O)Ra, C(═NORb)Ra, C(═N—NRzRb)Ra, CRaRb—ORz, CRaRb—NRzRc, ON(═CRaRb), O—C(═O)Ra, NRaRb′, NRa(C(═O)Rb), NRa(C(═O)ORb), NRa(C(═O)—NRzRb), NRa(C(═NRc)Rb), NRa(N═CRcRb), NRa—NRzRb, NRz—ORa, NRa(C(═NRc)—NRzRb), NRa(C(═NORc)Rb), processes for preparing these compounds, compositions comprising these compounds and their pesticidal use are described.

摘要翻译： 其中指数n和取代基L，Ra，Rb，Rc，Rz，Ru，Rv，A'，A“和A”'如说明书中所定义的式I的2-取代的嘧啶：R1 C 3 -C 10 - 烷基，C 3 -C 10 - 烯基，C 3 -C 10 - 炔基，C 3 -C 12 - 环烷基，C 3 -C 10 - 环烯基或五至十元饱和的部分不饱和或芳族杂环，其通过碳 并且含有一至四个由O，N和S组成的组的杂原子，R2是卤素，氰基，C1-C4-烷基，C2-C4-烯基，C2-C4-炔基，C1-C4-烷氧基，C3-C4 - 烯氧基或C 3 -C 4 - 炔氧基，其中R 2的烷基，烯基和炔基可以被卤素，氰基，硝基，C 1 -C 2 - 烷氧基或C 1 -C 4 - 烷氧基羰基取代，并且R 3是氰基，CO 2 R a，C（ -O）NR z R b，C（-O）-N-OR b，C（-S）-NR a R b，C（-NOR a）NR z R b，C（-NR a）NR z R b，C（O）NR a -NR b R b，C -NRaRb，C（-O）Ra，C（-NORb）Ra，C（-N-NRzRb）Ra，CRaRb-ORz，CRaRb-NRzRc，ON（-CRaRb），OC（-O）Ra，NRaRb ，NR a（C（-O）R b），NR a（C（-O）R b），NR a（C（-O）OR b） NRa-N RzRb，NRz-ORa，NRa（C（-NRc）-NRzRb），NRa（C（-NORc）Rb），制备这些化合物的方法，包含这些化合物的组合物及其杀虫剂用途。

公开(公告)号：US07465735B2

公开(公告)日：2008-12-16

申请号：US10495280

申请日：2002-11-15

申请人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D401/12 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A01N43/54

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D403/12

摘要： 5-Phenylpyrimidines, their preparation, compositions comprising them and their use 5-Phenylpyrimidines of the formula I in which the substituents and the index are as defined below: R1,R2 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, and R1 and R2 together with the nitrogen atom to which they are attached may also form a saturated or unsaturated ring which may be interrupted by an ether, thio, sulfoxyl or sulfonyl group and may be substituted by one to four groups Ra and/or Rb; R3 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy or alkenyloxy; R4 is hydrogen, halogen, cyano, hydroxyl, mercapto, azido, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, —ON═CRaRb, —CRc═NORa, —NRcN═CRaRb, —NRaRb, —NRcNRaRb, —NORa, —NRcC(═NRc′)NRaRb, —NRcC(═O)NRaRb, —NRaC(═O)Rc, —NRaC(═NORc)Rc′, —OC(═O)Rc, —C(═NORc)NRaRb, —CRc(═NNRaRb), —C(═O)NRaRb or —C(═O)Rc; in which Ra, Rb and Rc are as defined in the description; X is halogen, alkyl, alkoxy or haloalkyl; and m is an integer from 1 to 5; processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi are described.

摘要翻译： 其中取代基和指数如下定义的式I的5-苯基嘧啶：R1，R2是氢，烷基，卤代烷基，环烷基，卤代环烷基，烯基，卤代烯基，炔基或卤代炔基，R1和R2与氮原子一起 它们所连接的也可以形成可被醚，硫代，亚砜基或磺酰基中断的饱和或不饱和环，并且可以被一至四个基团R a和/或R b取代; R3是氢，卤素，氰基，烷基，卤代烷基，烷氧基，卤代烷氧基或烯氧基; R4是氢，卤素，氰基，羟基，巯基，叠氮基，烷基，烯基，炔基，卤代烷基，烷氧基，烯氧基，炔氧基，卤代烷氧基，烷硫基，烯硫基，炔硫基，卤代烷硫基，-ON-CRaRb，-CRc-NORa，-NRcN -CRaRb，-NRaRb，-NRcNRaRb，-NORa，-NRcC（-NRc'）NRaRb，-NRcC（-O）NRaRb，-NRaC（-O）Rc，-NRaC（-NORc）Rc'，-OC（ - O）R c，-C（-NOR c）NR a R b，-CR c（-NNR a R b）， - C（-O）NR a R b或-C（-O）R c; 其中Ra，Rb和Rc如说明书中所定义; X是卤素，烷基，烷氧基或卤代烷基; m为1〜5的整数。 描述了制备这些化合物的方法，包含它们的组合物及其用于控制​​有害真菌的用途。

公开(公告)号：US07375108B2

公开(公告)日：2008-05-20

申请号：US10564013

申请日：2004-07-15

申请人： Anja Schwögler ,  Markus Gewehr ,  Bernd Müller ,  Thomas Grote ,  Wassilios Grammenos ,  Jordi Tormo i Blasco ,  Andreas Gypser ,  Joachim Rheinheimer ,  Carsten Blettner ,  Peter Schäfer ,  Frank Schieweck ,  Oliver Wagner ,  Reinhard Stierl ,  Ulrich Schöfl ,  Siegfried Strathmann ,  Maria Scherer

发明人： Anja Schwögler ,  Markus Gewehr ,  Bernd Müller ,  Thomas Grote ,  Wassilios Grammenos ,  Jordi Tormo i Blasco ,  Andreas Gypser ,  Joachim Rheinheimer ,  Carsten Blettner ,  Peter Schäfer ,  Frank Schieweck ,  Oliver Wagner ,  Reinhard Stierl ,  Ulrich Schöfl ,  Siegfried Strathmann ,  Maria Scherer

IPC分类号： C07D239/42 ,  A01N43/54

CPC分类号： C07D239/42

摘要： The invention relates to 2-substituted pyrimidines of the formula I in which the index n and the substituents R1 to R3 and L are as defined in the description and R4 corresponds to one of the formulae in which Ra, X and Rb are as defined in the description; and also to processes for preparing these compounds, to pesticidal compositions comprising these compounds and to their use as pesticides.

摘要翻译： 本发明涉及式I的2-取代嘧啶，其中指数n和取代基R 1至R 3和L如说明书中所定义， SUP> 4 对应于其中R a，S，X和R b的定义之一如说明书中所定义; 以及制备这些化合物的方法，包括这些化合物的农药组合物及其作为农药的用途。

公开(公告)号：US20060211711A1

公开(公告)日：2006-09-21

申请号：US10550571

申请日：2004-03-30

申请人： Jordi Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

发明人： Jordi Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

IPC分类号： A61K31/519 ,  C07D487/04 ,  A01N43/90

CPC分类号： C07D487/04 ,  A01N43/90

摘要： 7-alkinylamino-triazolopyrimidins of formula (I), wherein the substituents have the following meanings: L=halogen, alkyl, halogenalkyl, alkoxy, amino, NHR, NR2, cyano, S(O)nA1 or C(O)A2; R=alkyl or alkylcarbonyl, A1=hydrogen, hydroxy, alkyl, alkylamino or aialkylamino; n=0, 1 or 2; A2=alkenyl, alkoxy, halogenalkoxy or one of the groups cited in A1; m=1, 2, 3, 4 or 5, whereby at least one group L is present in an ortho-position to the bond with the triazolopyrimidine skeleton; X=halogen, cyano, alkyl, halogenalkyl or alkoxy; R1=hydrogen or alkyl; R2=alkinyl which can be unsubstituted or substituted according to the description. The invention also relates to methods for the production of said compounds, agents containing said compounds and the use thereof to combat harmful phytopathogenic fungi.

摘要翻译： 式（I）的7-烷基氨基 - 三唑并嘧啶类，其中取代基具有以下含义：L =卤素，烷基，卤代烷基，烷氧基，氨基，NHR，NR 2，氰基，S（O） 或者C（O）A 2 O 2。 R =烷基或烷基羰基，A 1〜H 2，羟基，烷基，烷基氨基或亚烷基氨基; n = 0,1或2; 链烯基，烷氧基，卤代烷氧基或A 1中引用的基团之一; m = 1,2,3,4或5，其中至少一个基团L存在于与三唑并嘧啶骨架的键的邻位; X =卤素，氰基，烷基，卤代烷基或烷氧基; R 1 =氢或烷基; R 2 =炔基，其可以是未取代的或根据描述取代的。 本发明还涉及生产所述化合物的方法，含有所述化合物的试剂及其用于对抗有害植物病原真菌的用途。

公开(公告)号：US06956034B2

公开(公告)日：2005-10-18

申请号：US10477355

申请日：2002-05-17

申请人： Joachim Rheinheimer ,  Andreas Gypser ,  Ingo Rose ,  Thomas Grote ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  John-Bryan Speakman ,  Siegfried Strathmann ,  Gisela Lorenz

发明人： Joachim Rheinheimer ,  Andreas Gypser ,  Ingo Rose ,  Thomas Grote ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  John-Bryan Speakman ,  Siegfried Strathmann ,  Gisela Lorenz

IPC分类号： A01N43/86 ,  A01N43/90 ,  C07D265/24 ,  C07D498/04 ,  C07D513/04 ,  C07D413/04 ,  A61K31/536 ,  A61K31/5365

CPC分类号： C07D513/04 ,  A01N43/86 ,  A01N43/90 ,  C07D265/24

摘要： Oxazin(ethi)one compounds of the formula I: in which the variables Z, R1, R2, R3 and n are as defined in claim 1 and A is a 5- or 6-membered carbocycle or a 5- or 6-membered heterocycle having 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S, each of which cycles is attached via two carbon atoms to the oxazin(ethi)one ring, and the agriculturally useful salts of the oxazin(ethi)one compounds I are described. Moreover, the invention describes the use of compounds I and their salts for controlling phytopathogenic fungi, compositions which comprise the compounds I and/or their salts in a fungicidally effective amount and a method for controlling phytopathogenic fungi which comprises treating the fungi or the materials, plants, seeds or the soil threatened by fungal attack with a fungicidally effective amount of at least one compound of the formula I as claimed in claim 1 and/or a salt of I.

摘要翻译： 恶嗪（ethi）一种式I化合物，其中变量Z，R 1，R 2，R 3和n分别为 权利要求1中限定，A是5或6元碳环或具有1,2或3个选自N，O和S的杂原子的5或6元杂环，其中每个杂环通过 描述了两个碳原子与恶嗪（ethi）一个环，并且描述了恶嗪（ethi）一种化合物I的农业上有用的盐。 此外，本发明描述了化合物I及其盐用于控制植物病原真菌的用途，其包含化合物I和/或其盐的杀真菌有效量的组合物和控制植物病原真菌的方法，其包括处理真菌或物质， 用杀真菌有效量的至少一种如权利要求1所述的式I化合物和/或其盐的植物，种子或受真菌侵袭威胁的土壤。

公开(公告)号：US06559151B2

公开(公告)日：2003-05-06

申请号：US09735126

申请日：2000-12-12

申请人： Klaus Jüergen Pees ,  Frank Schieweck ,  Jordi Tormo I Blasco ,  Hubert Sauter ,  Oliver Cullman ,  Bernd Müller ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Eberhard Ammermann ,  Siegried Strathmann ,  Gisela Lorenz ,  Rheinhard Stierl

发明人： Klaus Jüergen Pees ,  Frank Schieweck ,  Jordi Tormo I Blasco ,  Hubert Sauter ,  Oliver Cullman ,  Bernd Müller ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Eberhard Ammermann ,  Siegried Strathmann ,  Gisela Lorenz ,  Rheinhard Stierl

IPC分类号： A01N4390

CPC分类号： C07D487/04

摘要： 6-(2-Trifluoromethyl-phenyl)-triazolopyrimidines of formula I in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, alkadienyl, or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or where R1 and R2 radicals may be unsubstituted or substituted as defined in the specification; or R1 and R2 together with the interjacent nitrogen atom represents a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted as defined in the specification; R3 is hydrogen, halogen, alkyl, alkoxy and haloalkyl; and X is halogen; processes and intermediates for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic fungi are described.

摘要翻译： 具有式Iin的6-（2-三氟甲基 - 苯基） - 三唑并嘧啶，其中R1和R2独立地表示氢或烷基，烯基，炔基，链二烯基或卤代烷基，环烷基，二环烷基，苯基，萘基或5-或6-元杂环基， 至四个氮原子或一至三个氮原子和一个硫或氧原子，或5-或6-元杂芳基，其含有1-4个氮原子或1-3个氮原子和一个硫或氧原子，或其中R1和R2基团可以 如说明书中所定义; 或R 1和R 2与中间的氮原子一起表示含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5或6元杂环，其可以如说明书中所定义而被取代; R3 是氢，卤素，烷基，烷氧基和卤代烷基; 和X是卤素;描述了制备这些化合物的方法和中间体，包含它们的组合物及其用于控制​​植物病原真菌的用途。

公开(公告)号：US06362380B1

公开(公告)日：2002-03-26

申请号：US09645980

申请日：2000-06-01

申请人： Karl Eicken ,  Joachim Gebhardt ,  Harald Rang ,  Michael Rack ,  Peter Schäfer

发明人： Karl Eicken ,  Joachim Gebhardt ,  Harald Rang ,  Michael Rack ,  Peter Schäfer

IPC分类号： C07C20500

CPC分类号： C07C253/30 ,  C07B37/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/35

摘要： A process for preparing nitrobiphenyls of the formula I where m is 1 or 2, R is halogen R′ or OR′, where R′ is a C-organic radical which may carry groups inert under the reaction conditions, n is 0, 1, 2 or 3, and, in the case of n being 2 or 3, the radicals R are the same or different, by reacting a chloronitrobenzene of the formula II in the presence of a palladium catalyst and a base in a solvent with a phenylboronic acid (IIIa) or an alkyl ester thereof of the formula IIIb where R1 is C1-C6-alkyl, or an anhydride thereof. The compounds I are useful as precursors for biphenylamines, which in turn are intermediates for fungicidal crop protection agents.

摘要翻译： 制备式I的硝基联苯的方法，其中m为1或2，R为卤素R'或OR'，其中R'为C-有机基团，其可以携带在反应条件下为惰性的基团，n为0,1,2 或3，并且在n为2或3的情况下，基团R相同或不同，通过使钯催化剂和碱在溶剂中的存在下的式II的氯硝基苯与苯基硼酸（IIIa ）或其中R 1为C 1 -C 6 - 烷基的式IIIb的烷基酯或其酸酐。化合物I可用作联苯胺的前体，其又是杀真菌作物保护剂的中间体。