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61.发明授权Dioxaphosphorinane compounds and polyolefin compositions sabilized therewith 失效二氧杂磷杂环壬烷化合物和与其稳定化的聚烯烃组合物
公开(公告)号：US4882374A
公开(公告)日：1989-11-21
申请号：US306130
申请日：1989-02-06
申请人： Richard H. S. Wang , Garry L. Myers
发明人： Richard H. S. Wang , Garry L. Myers
IPC分类号： C07F9/6574 , C07F9/6571 , C08K5/52 , C08K5/527 , C08L23/02
CPC分类号： C07F9/657118 , C08K5/527
摘要： Disclosed are novel cyclic phosphite compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl or aralkyl; R.sup.2 is hydrogen or alkyl; R.sup.3 is alkyl or aryl; and R.sup.4 and R.sup.5 each is alkyl. Also disclosed are polyolefin compositions stabilized with one or more of the above compounds.
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62.发明授权Method and system for forming a pharmaceutical product directly onto a packaging surface 有权用于将药物制品直接形成在包装表面上的方法和系统公开(公告)号：US08936825B2
公开(公告)日：2015-01-20
申请号：US13238024
申请日：2011-09-21
CPC分类号： A61K9/7007 , A61K31/47
摘要： The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.
摘要翻译： 本发明涉及在表面上形成诸如可溶性膜剂型的药物产品的方法。 特别地，本发明涉及直接在基材表面上形成药物产品的方法。
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63.发明授权Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions 有权包含抗粘合剂的快速溶解剂型的均匀薄膜公开(公告)号：US08765167B2
公开(公告)日：2014-07-01
申请号：US11517982
申请日：2006-09-08
CPC分类号： A61K9/7007 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/16 , A23P20/20 , A23P30/10 , A23V2002/00 , A61K9/0056 , A61K9/006 , A61K31/355 , A61K31/485 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/34 , A61K47/36 , A61K47/38 , A23V2200/30 , A23V2200/324 , A23V2250/21 , A23V2250/70 , A23V2250/156
摘要： The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.
摘要翻译： 本发明涉及含有抗粘连剂的水溶性薄膜及其制备方法。 防粘剂可以改善组合物的流动特性，从而减少膜粘附到使用者的口部或其它单元的膜的问题。 特别地，本发明涉及包含水溶性聚合物，选自化妆剂，药剂，维生素，生物活性剂及其组合的活性组分的薄膜组合物形式的食用水溶性递送系统和至少一种 防粘剂。
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公开(公告)号：US08663696B2
公开(公告)日：2014-03-04
申请号：US13588267
申请日：2012-08-17
申请人： Garry L. Myers , Samuel D. Hilbert , Bill J. Boone
发明人： Garry L. Myers , Samuel D. Hilbert , Bill J. Boone
IPC分类号： A61K9/14 , A61K9/70 , A61K38/00 , A61K31/335
CPC分类号： A61K9/7007 , A61K31/365 , A61K47/26 , A61K47/34 , A61K47/38
摘要： The present invention includes a pharmaceutical-based film system which includes various small-scale forms of pharmaceutically active agents, including tetrahydrolipstatin, in a film base. Such forms include nanoparticles, microparticles, and combinations thereof. Methods of producing such film and providing a dosage of the pharmaceutical in a film are also provided.
摘要翻译： 本发明包括药物基膜系统，其在膜基质中包括各种小规模形式的药物活性剂，包括四氢脂肪抑制素。 这些形式包括纳米颗粒，微粒及其组合。 还提供了制备这种膜并提供药物在膜中的剂量的方法。
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公开(公告)号：US08298583B2
公开(公告)日：2012-10-30
申请号：US11975584
申请日：2007-10-19
申请人： Garry L. Myers , Samuel D. Hilbert , Bill J. Boone
发明人： Garry L. Myers , Samuel D. Hilbert , Bill J. Boone
IPC分类号： A61K9/14 , A61K9/70 , A61K38/00 , A61K31/335
CPC分类号： A61K9/7007 , A61K31/365 , A61K47/26 , A61K47/34 , A61K47/38
摘要： The present invention includes a pharmaceutical-based film system which includes various small-scale forms of pharmaceutically active agents, including tetrahydrolipstatin, in a film base. Such forms include nanoparticles, microparticles, and combinations thereof. Methods of producing such film and providing a dosage of the pharmaceutical in a film are also provided.
摘要翻译： 本发明包括药物基膜系统，其在膜基质中包括各种小规模形式的药物活性剂，包括四氢脂肪抑制素。 这些形式包括纳米颗粒，微粒及其组合。 还提供了制备这种膜并提供药物在膜中的剂量的方法。
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66.发明申请公开(公告)号：US20120076921A1
公开(公告)日：2012-03-29
申请号：US13238024
申请日：2011-09-21
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K31/47
摘要： The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.
摘要翻译： 本发明涉及在表面上形成诸如可溶性膜剂型的药物产品的方法。 特别地，本发明涉及直接在基材表面上形成药物产品的方法。
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公开(公告)号：US20100297232A1
公开(公告)日：2010-11-25
申请号：US12468434
申请日：2009-05-19
IPC分类号： A61K9/10 , A61K47/02 , A61K31/4178
CPC分类号： A61K31/4178 , A23G4/06 , A61K9/006
摘要： The present invention relates to products and methods of making products having a taste masked active component. In particular, the present invention relates to taste-masked film dosage forms including at least one active component and a slow dissolving basic composition.
摘要翻译： 本发明涉及制备具有掩味活性成分的产品的产品和方法。 特别地，本发明涉及包含至少一种活性成分和缓慢溶解的碱性组合物的掩味膜剂型。
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公开(公告)号：US20080233174A1
公开(公告)日：2008-09-25
申请号：US12013989
申请日：2008-01-14
申请人： Garry L. Myers , Bill J. Boone , Samuel D. Hilbert
发明人： Garry L. Myers , Bill J. Boone , Samuel D. Hilbert
CPC分类号： A61K9/006 , A61K9/7007 , A61K47/10
摘要： This invention relates to films incorporating high amounts of pharmaceutical agents and methods for the preparation of the same. Moreover, the invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
摘要翻译： 本发明涉及含有大量药剂的薄膜及其制备方法。 此外，本发明涉及其制备的膜产品及其方法，其证明非自聚集均匀的异质性。 期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。 期望地，膜含有每单位面积膜的活性剂药物和/或化妆品活性剂不超过10％变化的药物和/或化妆品活性剂。
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69.发明授权Apparatus and process for strengthening low density compression dosage units and product therefrom 失效用于加强低密度压缩剂量单位及其产品的装置和方法
公开(公告)号：US5616344A
公开(公告)日：1997-04-01
申请号：US276244
申请日：1994-07-18
IPC分类号： A61J3/06 , A23G3/00 , A23G3/10 , A23G3/36 , A61J3/10 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/70 , B30B11/02
CPC分类号： A23G3/10 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027
摘要： The present invention is a process for forming a low density compression dosage unit to provide increased strength. The process of the present invention includes compacting under bi-level compaction pressure to provide a continuous-volume dosage unit which has a first volume defining an edge portion of the unit and a density which is greater than a density of a second volume defining a non-edge portion of the unit. The present invention also includes the product resulting from the process and apparatus used to make such units.
摘要翻译： 本发明是形成低密度压缩剂量单位以提高强度的方法。 本发明的方法包括在双层压实压力下进行压实以提供连续体积剂量单位，其具有限定单元的边缘部分的第一体积，并且密度大于限定非水平的第二体积的密度 - 部分的单位。 本发明还包括由用于制造这种单元的方法和装置产生的产品。
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公开(公告)号：US5266303A
公开(公告)日：1993-11-30
申请号：US983337
申请日：1992-11-30
CPC分类号： A61Q5/06 , A61K8/046 , A61K8/85 , Y10S424/01
摘要： This invention relates to aerosol hair spray formulations based on (1) a sulfonate-containing, water-dispersible or water-dissipatible, linear polyester having a glass transition temperature of about 36.degree. C. to about 40.degree. C. and (2) a water-soluble, polyvinyl lactam polymer. In addition, the formulations contain water as the liquid vehicle and a propellant. Such aerosol hair spray formulations do not contain any volatile organic compounds other than propellant yet exhibit fast drying times and excellent performance characteristics.
摘要翻译： 本发明涉及基于（1）具有约36℃至约40℃的玻璃化转变温度的含磺酸盐的水分散性或水分散性或水分散性线性聚酯的气溶胶喷发剂，和（2） 水溶性聚乙烯内酰胺聚合物。 此外，制剂含有作为液体载体的水和推进剂。 这种气溶胶喷发剂不包含除推进剂之外的任何挥发性有机化合物，但表现出快速干燥时间和优异的性能特征。
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