公开(公告)号：US08299246B2

公开(公告)日：2012-10-30

申请号：US13412907

申请日：2012-03-06

申请人： Stephen Brough ,  Richard Evans ,  Timothy Jon Luker ,  Piotr Raubo

发明人： Stephen Brough ,  Richard Evans ,  Timothy Jon Luker ,  Piotr Raubo

IPC分类号： C07D241/00 ,  A61K31/4965

CPC分类号： C07D491/113 ,  C07D241/08 ,  C07D241/20 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D471/10

摘要： The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明涉及式（I）的吡嗪酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US20100309279A1

公开(公告)日：2010-12-09

申请号：US12477874

申请日：2009-06-03

申请人： John Michael Tamkin ,  John Michael Rodgers ,  Matthew Scott Howarth ,  Richard Evans ,  Richard Hirst

发明人： John Michael Tamkin ,  John Michael Rodgers ,  Matthew Scott Howarth ,  Richard Evans ,  Richard Hirst

IPC分类号： B41J2/47 ,  G02B27/30 ,  G02B17/08 ,  G02B3/08

CPC分类号： F21V13/04 ,  B41J2/45 ,  F21V5/007 ,  G02B17/0828

摘要： An imaging system. An array of light sources and an array of lenses corresponding to the light sources and having optical axes substantially parallel to one another are provided. The lenses produce collimated output beams. An afocal optical relay having an optical axis substantially parallel to the optical axes of the lenses is also included, the array of lenses being positioned relative to the afocal optical relay so as to form an optical system that produces an image of each collimated output beam on an image plane, each image having a prescribed depth of focus and spot size. The light sources preferably are lasers producing an array of respective laser beams having high intensity and a long waist. A system for writing information on a light-sensitive label includes the imaging system. Methods of imaging and of writing information on a light-sensitive label are also provided.

摘要翻译： 成像系统。 提供了一组光源和对应于光源并且具有基本上彼此平行的光轴的透镜阵列。 镜头产生准直输出光束。 还包括具有基本上平行于透镜的光轴的光轴的远焦光学继电器，透镜阵列相对于远焦光学继电器定位，以便形成光学系统，其产生每个准直输出光束的图像 图像平面，每个图像具有规定的焦点深度和斑点大小。 光源优选地是产生具有高强度和长腰的相应激光束阵列的激光器。 用于在光敏标签上写入信息的系统包括成像系统。 还提供了在光敏标签上成像和写入信息的方法。

公开(公告)号：US07792089B2

公开(公告)日：2010-09-07

申请号：US10210777

申请日：2002-07-31

申请人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

发明人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

IPC分类号： H04B7/212

CPC分类号： B61L3/127 ,  B61L2205/04

摘要： A system and method for remotely controlling an increased number of subsystems having an onboard locomotive control unit (LCU) and two associated operator control units (OCUs) on a single wireless channel. A time slot is assigned to each subsystem for making two-way transmissions to control the locomotive. A signal from an external timing source synchronizes each subsystem to minimize interference between transmissions from different subsystems. Time slots are assigned manually or automatically over a wireless network or by the LCU after monitoring the channel. The LCU automatically selects the direct or repeater transmission path depending upon whether or not it receives polling message responses from its associated OCUs. A GPS receiver in each subsystem receives the synchronization signal and provides geographic positioning data so the LCU can determine when to execute predefined, position-based commands. The secondary OCU may be turned off and rejoined to the subsystem without ceasing operation.

摘要翻译： 一种用于在单个无线信道上远程控制具有机载机车控制单元（LCU）和两个相关联的运营商控制单元（OCU）的子系统的数量增加的系统和方法。 分配给每个子系统的时隙进行双向传输以控制机车。 来自外部定时源的信号使每个子系统同步以最小化来自不同子系统的传输之间的干扰。 通过无线网络或LCU监控频道后，手动或自动分配时隙。 根据是否从其相关联的OCU接收到轮询消息响应，LCU自动选择直接或中继传输路径。 每个子系统中的GPS接收器接收同步信号并提供地理定位数据，以便LCU可以确定何时执行预定义的基于位置的命令。 次级OCU可以关闭并重新连接到子系统而不停止运行。

公开(公告)号：US20100105642A1

公开(公告)日：2010-04-29

申请号：US12486854

申请日：2009-06-18

申请人： Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Richard Evans ,  Piotr Raubo

发明人： Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Richard Evans ,  Piotr Raubo

IPC分类号： A61K31/536 ,  C07D265/36 ,  A61K31/56 ,  A61P29/00

CPC分类号： C07D231/12 ,  A61K31/538 ,  A61K45/06 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明提供式（I）化合物，其中W，R 1，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US07535865B2

公开(公告)日：2009-05-19

申请号：US10632525

申请日：2003-07-31

申请人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

发明人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

IPC分类号： H04W4/00

CPC分类号： B61L3/127 ,  B61L2205/04

摘要： A system and method for remotely controlling an increased number of subsystems having an onboard locomotive control unit (LCU) and two associated operator control units (OCUs) on a single wireless channel. A time slot is assigned to each subsystem for making two-way transmissions to control the locomotive. A signal from an external timing source synchronizes each subsystem to minimize interference between transmissions from different subsystems. Time slots are assigned manually or automatically over a wireless network or by the LCU after monitoring the channel. The LCU automatically selects the direct or repeater transmission path depending upon whether or not it receives polling message responses from its associated OCUs. A GPS receiver in each subsystem receives the synchronization signal and provides geographic positioning data so the LCU can determine when to execute predefined, position-based commands. The secondary OCU may be turned off and rejoined to the subsystem without ceasing operation.

公开(公告)号：US20080028854A1

公开(公告)日：2008-02-07

申请号：US11906409

申请日：2007-10-01

申请人： Richard Evans

发明人： Richard Evans

IPC分类号： G01D11/24

CPC分类号： G01N21/01 ,  G01N21/251 ,  G01N21/274 ,  G01N2021/035 ,  G01N2201/022 ,  G01N2201/0224

摘要： Devices and methods are provided for measuring a property of a sample, such as an optical property. Embodiments of the subject invention include a device having sample measurement componentry and one or more enclosure-forming components, wherein one or more of the enclosure-forming components are movable, and wherein the device is configured so that one or more of the enclosure-forming components have a positional relationship that can change from an open position to a closed position in which one or more of the enclosure-forming components define an enclosed space accessible by the sample measurement componentry. Also provided are systems and kits.

摘要翻译： 提供了用于测量样品的性质（例如光学性质）的装置和方法。 本发明的实施例包括具有样品测量部件和一个或多个外壳形成部件的装置，其中一个或多个外壳形成部件是可移动的，并且其中该装置构造成使得一个或多个外壳形成 组件具有可以从打开位置改变到关闭位置的位置关系，其中一个或多个外壳形成组件限定由样本测量组件可访问的封闭空间。 还提供系统和工具包。

公开(公告)号：US20070276141A1

公开(公告)日：2007-11-29

申请号：US10578236

申请日：2004-11-03

申请人： Howard Else ,  Richard Evans ,  Peter Morgan ,  Philip O'keefe ,  Matthew Perry ,  Phil Plumb ,  Mark Purdie ,  Brian Springthorpe ,  Gerald Steele

发明人： Howard Else ,  Richard Evans ,  Peter Morgan ,  Philip O'keefe ,  Matthew Perry ,  Phil Plumb ,  Mark Purdie ,  Brian Springthorpe ,  Gerald Steele

IPC分类号： C07D211/40

CPC分类号： C07D401/04

摘要： The invention provides anhydrous and hydrated forms of sodium salt of N-[[4-(3,4-dichlorophenoxy)[1,4′-bipiperidin]-1′-yl]carbonyl]-4-methyl-benzenesulfonamide and crystalline forms of N-[[4-(3,4-dichlorophenoxy)[1,4′-bipiperidin]-1′-yl]carbonyl]-4-methyl-benzenesulfonamide; and such compounds are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

摘要翻译： 本发明提供无水和水合形式的N - [[4-（3,4-二氯苯氧基）[1,4'-联哌啶] -1'-基]羰基] -4-甲基 - 苯磺酰胺的钠盐和 N - [[4-（3,4-二氯苯氧基）[1,4'-联哌啶] -1'-基]羰基] -4-甲基 - 苯磺酰胺; 并且这些化合物是趋化因子（特别是CCR3）活性的调节剂，并且特别可用于治疗哮喘和/或鼻炎。

公开(公告)号：US20060205346A1

公开(公告)日：2006-09-14

申请号：US11367955

申请日：2006-03-03

申请人： Richard Evans ,  Peter Karabinis

发明人： Richard Evans ,  Peter Karabinis

IPC分类号： H04B1/00

CPC分类号： H04B1/1036 ,  H04B7/18513

摘要： Methods of reducing interference in wireless communications in a communications system are provided. A wireless communications signal is received within a frequency band. The wireless communications signal includes a desired component and an undesired interference component. The interference component may be caused by, for example, communications by another component of the communications system using frequencies in the frequency band. The received communications signal is converted to a frequency domain representation. Frequencies of the interference component of the frequency domain signal are identified. At least some of the identified frequencies of the interference component of the frequency domain signal are attenuated to generate an interference attenuated frequency domain signal. The interference attenuated frequency domain signal is converted to an interference attenuated time domain signal.

公开(公告)号：US20060144732A1

公开(公告)日：2006-07-06

申请号：US11322343

申请日：2006-01-03

申请人： Pablo Kaplan ,  Richard Evans

发明人： Pablo Kaplan ,  Richard Evans

IPC分类号： A45C11/26

CPC分类号： B62B1/125 ,  B25H3/00 ,  B62B1/26 ,  B62B2202/028 ,  B62B2202/48

摘要： A tool caddy comprises a rigid bucket and a non-rigid tool organizer. The bucket comprises a bottom support portion, with vertical walls extending upwardly therefrom, forming front, back and side faces and defining a bucket interior, and an upper rim. The bucket further comprises at least two wheels and a retractable arm with a handgrip. The arm is extendable between a fully extended position and a fully retracted position and is attached to the bucket at the back face thereof. The bucket also has a sheath, integral with the back face of the bucket and giving rise to a receptacle adapted for slidingly receiving the arm. The tool organizer comprises exterior flaps adapted to cover outward faces of the bucket and interior flaps adapted to cover interior faces of the bucket. The exterior flaps are of sufficient length to substantially cover at least the entire front face of the bucket and is formed so as to not interfere with the operation of the wheels. The tool organizer also has contrivances, disposed on the flaps, for retaining various articles.

摘要翻译： 工具箱包括刚性铲斗和非刚性工具组织器。 铲斗包括底部支撑部分，具有从其向上延伸的垂直壁，形成前部，后部和侧面并限定铲斗内部和上部边缘。 铲斗还包括至少两个轮子和具有手柄的伸缩臂。 臂在完全伸出位置和完全缩回位置之间是可延伸的，并且在其背面附接到铲斗。 铲斗还具有与铲斗的后表面成一体的护套，并产生适于滑动地接收臂的插座。 工具组织器包括适于覆盖铲斗的外表面的外部襟翼和适于覆盖铲斗的内表面的内襟翼。 外部翼片具有足够的长度以基本上覆盖至少整个铲斗的前表面，并且形成为不妨碍车轮的操作。 工具组织者也有设计，放在襟翼上，用于保留各种物品。

公开(公告)号：US20060109468A1

公开(公告)日：2006-05-25

申请号：US10997169

申请日：2004-11-24

申请人： Richard Evans

发明人： Richard Evans

IPC分类号： G01N21/00

CPC分类号： G01N21/01 ,  G01N21/251 ,  G01N21/274 ,  G01N2021/035 ,  G01N2201/022 ,  G01N2201/0224

摘要： Devices and methods are provided for measuring a property of a sample, such as an optical property. Embodiments of the subject invention include a device having sample measurement componentry and one or more enclosure-forming components, wherein one or more of the enclosure-forming components are movable, and wherein the device is configured so that one or more of the enclosure-forming components have a positional relationship that can change from an open position to a closed position in which one or more of the enclosure-forming components define an enclosed space accessible by the sample measurement componentry. Also provided are systems and kits.

摘要翻译： 提供了用于测量样品的性质（例如光学性质）的装置和方法。 本发明的实施例包括具有样品测量部件和一个或多个外壳形成部件的装置，其中一个或多个外壳形成部件是可移动的，并且其中该装置构造成使得一个或多个外壳形成 组件具有可以从打开位置改变到关闭位置的位置关系，其中一个或多个外壳形成组件限定由样本测量组件可访问的封闭空间。 还提供系统和工具包。