公开(公告)号：US08225643B2

公开(公告)日：2012-07-24

申请号：US12125533

申请日：2008-05-22

申请人： Marwan Abboud ,  Rachid Mahrouche ,  Teresa Ann Mihalik ,  Chadi Harmouche ,  Jean-Luc Pageard ,  John W. Lehmann

发明人： Marwan Abboud ,  Rachid Mahrouche ,  Teresa Ann Mihalik ,  Chadi Harmouche ,  Jean-Luc Pageard ,  John W. Lehmann

IPC分类号： G01M3/26

CPC分类号： A61B18/02 ,  A61B2017/00084 ,  A61B2018/0022 ,  A61B2018/00577 ,  A61B2018/00744 ,  A61B2018/00863 ,  A61B2018/00898 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  G01M3/02 ,  G01M3/2846

摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.

摘要翻译： 本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。 医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。 提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。 此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。 另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

公开(公告)号：US07404816B2

公开(公告)日：2008-07-29

申请号：US10889620

申请日：2004-07-12

申请人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

发明人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12

摘要： A surgical device includes a device body defining a sealed fluid path having a first end and a second end, a refrigerant supply in communication with the first end of the sealed fluid path, and a vacuum source in communication with the second end of the sealed fluid path. Leak detection apparatus can be provided in communication with the sealed fluid path.

摘要翻译： 手术装置包括限定具有第一端和第二端的密封流体路径的装置主体，与密封流体路径的第一端连通的制冷剂供应源和与密封流体的第二端连通的真空源 路径。 泄漏检测装置可以与密封流体通道连通。

公开(公告)号：US06733494B2

公开(公告)日：2004-05-11

申请号：US10124558

申请日：2002-04-17

申请人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

发明人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12

摘要： A surgical device includes a device body defining a sealed fluid path having a first end and a second end, a refrigerant supply in communication with the first end of the sealed fluid path, and a vacuum source in communication with the second end of the sealed fluid path. Leak detection apparatus can be provided in communication with the sealed fluid path.

公开(公告)号：US06569158B1

公开(公告)日：2003-05-27

申请号：US09489707

申请日：2000-01-24

申请人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

发明人： Marwan Abboud ,  Johnny Al Asmar ,  John W. Lehmann

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12

摘要： A surgical device includes a device body defining a sealed fluid path having a first end and a second end, a refrigerant supply in communication with the first end of the sealed fluid path, and a vacuum source in communication with the second end of the sealed fluid path. Leak detection apparatus can be provided in communication with the sealed fluid path.

公开(公告)号：US20050182393A1

公开(公告)日：2005-08-18

申请号：US11106839

申请日：2005-04-15

申请人： Marwan Abboud ,  Sean Carroll ,  Fred Milder ,  Jean-Pierre Desmarais ,  Steve Arless ,  George Klein

发明人： Marwan Abboud ,  Sean Carroll ,  Fred Milder ,  Jean-Pierre Desmarais ,  Steve Arless ,  George Klein

IPC分类号： A61B17/00 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61B18/24

CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/24 ,  A61B2017/00053 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61B2018/0262

摘要： An integrated multiple energy ablation system that allows for a variety of ablation procedures to be performed without the interchanging of catheters. A console is provided that is connected to one or more energy treatment devices such as catheters or probes, via an energy-delivering umbilical system. A processor in the console allows a user to selectively control which type of energy is released into the umbilical system and delivered to the energy treatment devices. Cryogenic fluid, RF energy, microwave or direct current as well as laser energy can be supplied in order to cover a wide range of ablation techniques. The integrated ablation station is designed to be compatible with commercial catheters and allows for sequential or simultaneous ablation and mapping procedures to be performed when a deeper and wider lesion capability and/or a broader temperature ablation spectrum is desired.

摘要翻译： 一种集成的多能量消融系统，其允许在不互换导管的情况下执行各种消融程序。 提供了通过能量输送脐带系统连接到一个或多个能量处理装置（例如导管或探针）的控制台。 控制台中的处理器允许用户选择性地控制哪种类型的能量被释放到脐带系统中并被递送到能量处理装置。 可以提供低温流体，RF能量，微波或直流电流以及激光能量以覆盖广泛的消融技术。 集成消融台被设计为与商业导管兼容，并且允许在需要更深和更宽的损伤能力和/或更宽的温度消融光谱时执行顺序或同时的消融和绘图程序。

公开(公告)号：US07591814B2

公开(公告)日：2009-09-22

申请号：US11093179

申请日：2005-03-29

申请人： Domenic Santoianni ,  Marwan Abboud ,  Sean Carroll

发明人： Domenic Santoianni ,  Marwan Abboud ,  Sean Carroll

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00053 ,  A61B2017/00243 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A catheter having an extended treatment zone for cooling tissue is provided. The catheter includes an elongate catheter body having a distal tip, and a fluid injection conduit disposed inside the catheter body defining a return lumen therein. The fluid injection conduit further defines two or more injection orifices including a first distal orifice near the distal tip, and a second orifice longitudinally offset along the fluid injection conduit to be less proximate the distal tip than the first orifice. Fluid cryogen flowing through the orifices creates an extended tissue cooling contour about the distal end portion of the catheter. At least one ECG ring electrode is provided about the catheter body near the second orifice. The catheter may thus provide for electrocardiographic mapping of tissue nodes lying transversely between the distal tip and the ECG ring electrode.

摘要翻译： 提供了一种具有用于冷却组织的延伸处理区的导管。 导管包括具有远侧末端的细长导管主体和设置在导管主体内部的流体注入导管，其在其中限定回流腔。 流体注射导管还限定两个或更多个注射孔，其包括靠近远侧末端的第一远端孔，以及沿着流体注射导管纵向偏移的第二孔，以比第一孔更靠近远端。 流经孔的流体冷冻剂围绕导管的远端部分产生延长的组织冷却轮廓。 在第二孔周围的导管本体周围设置至少一个ECG环形电极。 因此，导管可以提供横向位于远端尖端和ECG环形电极之间的组织结节的心电图。

公开(公告)号：US20060100495A1

公开(公告)日：2006-05-11

申请号：US11093179

申请日：2005-03-29

申请人： Domenic Santoianni ,  Marwan Abboud ,  Sean Carroll

发明人： Domenic Santoianni ,  Marwan Abboud ,  Sean Carroll

IPC分类号： A61B5/04 ,  A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00053 ,  A61B2017/00243 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A catheter having an extended treatment zone for cooling tissue is provided. The catheter includes an elongate catheter body having a distal tip, and a fluid injection conduit disposed inside the catheter body defining a return lumen therein. The fluid injection conduit further defines two or more injection orifices including a first distal orifice near the distal tip, and a second orifice longitudinally offset along the fluid injection conduit to be less proximate the distal tip than the first orifice. Fluid cryogen flowing through the orifices creates an extended tissue cooling contour about the distal end portion of the catheter. At least one ECG ring electrode is provided about the catheter body near the second orifice. The catheter may thus provide for electrocardiographic mapping of tissue nodes lying transversely between the distal tip and the ECG ring electrode.

公开(公告)号：US07527622B2

公开(公告)日：2009-05-05

申请号：US10887271

申请日：2004-07-08

申请人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

发明人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

IPC分类号： A61B18/18 ,  A61M29/00

CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.

摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。 传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

公开(公告)号：US20080215043A1

公开(公告)日：2008-09-04

申请号：US12120439

申请日：2008-05-14

申请人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

发明人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

摘要翻译： 本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。 在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分 心脏组织的形貌。 消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。 气球的表面可以通过调节一个或多个气囊内的压力而进一步成形。 在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。 在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

公开(公告)号：US20070255162A1

公开(公告)日：2007-11-01

申请号：US11283057

申请日：2005-11-18

申请人： Marwan Abboud ,  Johnny Asmar ,  Chadi Harmouche

发明人： Marwan Abboud ,  Johnny Asmar ,  Chadi Harmouche

IPC分类号： A61B5/05

CPC分类号： A61B5/0537 ,  A61B18/02 ,  A61B2017/00026 ,  A61B2018/0022 ,  A61B2018/0212

摘要： Methods and systems for detecting fluid egress, assessing lesion quality, determining tissue composition or structure, determining ice coverage of catheter tip and providing tissue contact assessment, by providing a catheter having a shaft with a proximal end portion and a distal end portion, the proximal end portion and the distal end portion define at least one fluid pathway therebetween with the shaft having a plurality of electrodes, positioning the catheter at a tissue treatment site, applying an electrical current between at least two of the plurality of electrodes, measuring impedance voltage between the at least two of the plurality of electrodes and, processing the measured impedance voltage caused by the applied electrical current to determine if fluid egress is present, to assess lesion quality, to determine tissue composition, ice cover of catheter tip, and to provide contact assessment. The system may have a control unit, a microprocessor, an impedance measuring device or the like to perform processing of impedance data.

摘要翻译： 用于检测流体出口的方法和系统，评估病变质量，确定组织组成或结构，通过提供具有近端部分和远端部分的轴的导管，确定导管尖端的冰覆盖和提供组织接触评估， 末端部分和远端部分限定其间的至少一个流体通路，其中轴具有多个电极，将导管定位在组织治疗部位，在多个电极中的至少两个之间施加电流，测量多个电极之间的阻抗电压 所述多个电极中的至少两个，并且处理由施加的电流引起的测量的阻抗电压以确定是否存在流体出口，以评估病变质量，确定组织组成，导管尖端的冰盖，并提供接触 评定。 系统可以具有控制单元，微处理器，阻抗测量装置等，以执行阻抗数据的处理。