利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.021 秒)

    Wide area ablation of myocardial tissue
    1.
    发明授权
    Wide area ablation of myocardial tissue 有权
    广泛消融心肌组织

    公开(公告)号：US08475440B2

    公开(公告)日：2013-07-02

    申请号：US11953189

    申请日：2007-12-10

    申请人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    发明人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

    摘要翻译： 本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。 在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分 心脏组织的形貌。 消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。 球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。 在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。 在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

    WIDE AREA ABLATION OF MYOCARDIAL TISSUE
    2.
    发明申请
    WIDE AREA ABLATION OF MYOCARDIAL TISSUE 有权
    心肌组织的大面积消融

    公开(公告)号：US20080215043A1

    公开(公告)日：2008-09-04

    申请号：US12120439

    申请日：2008-05-14

    申请人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    发明人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

    摘要翻译： 本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。 在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分 心脏组织的形貌。 消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。 气球的表面可以通过调节一个或多个气囊内的压力而进一步成形。 在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。 在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

    Wide area ablation of myocardial tissue
    3.
    发明授权
    Wide area ablation of myocardial tissue 有权
    广泛消融心肌组织

    公开(公告)号：US08679104B2

    公开(公告)日：2014-03-25

    申请号：US12120439

    申请日：2008-05-14

    申请人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    发明人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

    摘要翻译： 本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。 在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管本体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分 心脏组织的形貌。 消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。 球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。 在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。 在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

    Wide area ablation of myocardial tissue
    4.
    发明授权
    Wide area ablation of myocardial tissue 有权
    广泛消融心肌组织

    公开(公告)号：US07794455B2

    公开(公告)日：2010-09-14

    申请号：US11119399

    申请日：2005-04-29

    申请人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    发明人： Marwan Abboud ,  Fredric L. Milder ,  George Klein

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

    摘要翻译： 本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。 在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分 心脏组织的形貌。 消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。 球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。 在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。 在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

    Catheter system
    5.
    发明授权
    Catheter system 失效

    公开(公告)号：US06730077B2

    公开(公告)日：2004-05-04

    申请号：US10237376

    申请日：2002-09-09

    申请人： Sean Carroll ,  George Klein ,  Marwan Abboud ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger

    发明人： Sean Carroll ,  George Klein ,  Marwan Abboud ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger

    IPC分类号： A61B1802

    CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/065

    摘要： A cryocatheter for treatment of tissue has a tip adapted to provide a signal indicative of the quality and/or orientation of the tip contact with surrounding tissue. In one embodiment, a signal conductor extends through the catheter to the tip and connects to a thermally and electrically conductive shell or cap that applies an RF current to the region of tissue contacted by the tip. The tissue impedance path between the signal lead and a surface electrode mounted on the patient's skin is monitored to develop a quantitative measure of tissue contact at the distal tip, which is preferably displayed on the screen of a catheter monitoring console. In yet a further embodiment, the catheter is provided with a split tip having temperature monitoring sensors, such as thermistors, mounted on opposed halves of the tip so as to sense temperature on two sides of the catheter axis. The thermistor signals are processed to determine and display differential temperature between the two sides of the tip, thus revealing which side lies in contact. In yet a further aspect of the first embodiment, two separate and distinct high frequency electrical signals are applied to the two halves of a split metal shell or cap at the tip. Signals received at the surface electrode are filtered into first and second frequency components, and these are processed to determine the relative magnitude of the signal or the impedance of the path for each of the injected signals to determine and display the tissue contact orientation of the catheter. The catheter preferably has two separate cooling chambers within the cooling tip, positioned with one chamber on each side of the axis, and a separate cooling inlet to each chamber is switched on by a valve which directs the flow of coolant to the contact side during active cryotreatment. In another embodiment, the cap provides an RF electrode that may be opposed to the cooling side so that either the cryogenic or the RF ablation side may be rotated into contact to selectively heat or cool, or in representative protocol treat, then thaw, the same tissue site.

    Catheter with cryogenic and electrical heating ablation
    6.
    发明授权
    Catheter with cryogenic and electrical heating ablation 有权
    导管用低温和电加热消融

    公开(公告)号：US07896870B2

    公开(公告)日：2011-03-01

    申请号：US11768259

    申请日：2007-09-10

    申请人： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    发明人： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    IPC分类号： A61B18/02 ,  A61B18/12 ,  A61B18/18

    CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/0212 ,  A61B2018/0268

    摘要： A catheter includes a cryoablation tip with an ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber and have an RF electrode at its distal end. The electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled in combination with an RF treatment regimen to enhance the lesion size, speed or placement of multi-lesion or single lesion cycles. In one embodiment a microwave energy source operates to extend beyond the thermal conduction depth, or penetrate the ice ball and be absorbed in tissue beyond an ice boundary, thus extending a dimension of treatment. Also, the cooling and application of RF energy can be controlled to position the ablation region away from the surface contacted by the electrode thereby leaving surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth.

    摘要翻译： 导管包括具有用于加热组织的消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室实现，并且在其远端具有RF电极。 可以操作电极以温热低温冷却的组织，或者可以与RF治疗方案结合控制冷却剂，以增强病变大小，速度或多损伤或单个病变周期的放置。 在一个实施例中，微波能量源的作用是延伸超过热传导深度，或者穿透冰球并被吸收在超过冰界的组织中，从而延伸处理的尺寸。 此外，可以控制RF能量的冷却和施加，以使消融区域远离与电极接触的表面，从而在深度消融时使表面组织不受伤害，或者提供具有更高均匀度的消融带，并且随着深度增加。

    Catheter with cryogenic and electrical heating ablation
    8.
    发明授权
    Catheter with cryogenic and electrical heating ablation 有权
    导管用低温和电加热消融

    公开(公告)号：US07951140B2

    公开(公告)日：2011-05-31

    申请号：US11971582

    申请日：2008-01-09

    申请人： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    发明人： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/0212 ,  A61B2018/0268

    摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles.

    摘要翻译： 导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变 治疗或单次病变再治疗周期。