公开(公告)号：US20080039681A1

公开(公告)日：2008-02-14

申请号：US11876586

申请日：2007-10-22

Applicant: Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven Anderson

Inventor： Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven Anderson

IPC: A61F2/02

CPC classification number: A61B17/00234 ,  A61B17/06166 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/06052

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

公开(公告)号：US20080004692A1

公开(公告)日：2008-01-03

申请号：US11477152

申请日：2006-06-28

Applicant: Michael R. Henson ,  Shahram Moaddeb ,  Samuel M. Shaolian

Inventor： Michael R. Henson ,  Shahram Moaddeb ,  Samuel M. Shaolian

IPC: A61F2/06

CPC classification number: A61F2/88 ,  A61B17/12022 ,  A61B17/12118 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2002/30098 ,  A61F2002/301 ,  A61F2210/0033 ,  A61F2210/0038

Abstract: Methods and devices are provided for providing a protective framework for treating an aneurysm with embolic coils and preventing mitigation of the embolic coils from the aneurysm. A dynamically remodelable stent having a first and a second configuration is delivered into the blood vessel patient, such as a human or other animal, and positioned adjacent an ostium of an aneurysm while in the first, linear configuration. The dynamically remodelable stent may then be activated to assume a second, expanded configuration and thereby provide a protective framework spanning the neck of the aneurysm during and after delivery of embolic devices, such as embolic coils, to the aneurysm. The stent can be activated within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. In certain embodiments, the stent include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field.

Abstract translation: 提供了用于提供用于治疗具有栓塞线圈的动脉瘤的保护框架并且防止来自动脉瘤的栓塞线圈的方法和装置。 具有第一和第二构型的动态可重塑支架被递送到诸如人或其他动物的血管患者中，并且在第一线性构型中位于动脉瘤的口附近。 动态可重塑支架然后可以被激活以呈现第二扩张构型，从而在栓塞装置（例如栓塞线圈）输送到动脉瘤期间和之后提供横跨动脉瘤颈部的保护框架。 支架可以以微创或非侵入性方式在患者体内激活，例如通过经皮或外部施加能量到患者身体。 能量可以包括例如声能，射频能量，光能和磁能。 在某些实施例中，支架包括响应温度变化和/或暴露于磁场的形状记忆材料。

公开(公告)号：US20070145281A1

公开(公告)日：2007-06-28

申请号：US11610196

申请日：2006-12-13

Applicant: Shlomo Ben-Haim ,  Benny Rousso ,  Shahram Moaddeb

Inventor： Shlomo Ben-Haim ,  Benny Rousso ,  Shahram Moaddeb

IPC: G01T1/24

CPC classification number: G01T1/1648 ,  G01T1/249

Abstract: A gamma ray camera system is provided, which includes a lens system comprising at least one crystal diffraction lens, and a camera. The camera is configured to perform gamma ray imaging of a first region of a volume of interest using the lens system, and perform gamma ray imaging of a second region of the volume of interest without using the lens system. Other embodiments are also described.

Abstract translation: 提供了一种伽马射线照相机系统，其包括包括至少一个晶体衍射透镜的透镜系统和照相机。 相机被配置为使用透镜系统对感兴趣体积的第一区域进行伽马射线成像，并且在不使用透镜系统的情况下执行感兴趣体积的第二区域的伽马射线成像。 还描述了其它实施例。

公开(公告)号：US20070055368A1

公开(公告)日：2007-03-08

申请号：US11514292

申请日：2006-08-31

Applicant: Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2250/0001 ,  A61F2250/0004

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices comprise a shape memory material, and further include a body member and an insert member. The body member has a circumference and a slot that extends at least partially along the circumference of the body. The insert member extends at least partially along the circumference of the body. The device has a first shape in a first configuration and a second shape in a second configuration, and is configured to transform from a first configuration to a second configuration in response to a first activation energy applied thereto.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 这些装置可以以微创或非侵入性的方式在患者身体内进行调节，例如通过经皮或外部给患者身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括形状记忆材料，并且还包括主体构件和插入构件。 主体构件具有至少部分地沿主体的圆周延伸的圆周和狭槽。 插入构件至少部分地沿身体的圆周延伸。 该装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的第一激活能量而从第一配置变换到第二配置。

公开(公告)号：US20060241746A1

公开(公告)日：2006-10-26

申请号：US11111682

申请日：2005-04-21

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb

IPC: A61F2/24 ,  A61N2/10

CPC classification number: A61F2/2451 ,  A61B2017/00876 ,  A61F2210/009

Abstract: Methods and devices for reshaping or reforming tissue, such as a mitral valve of a heart, are described. An implant includes a generally flexible body and a plurality of magnetic portions such that the magnetic portions interact to cause a change in the shape of the implant, which, in turn, effects a change in shape of the subject tissue. In one example, at least one implant is positioned within a coronary sinus to affect the shape of the mitral valve annulus. The implant may further include fixation mechanisms for securing the implant within a vessel and may provide for removability after desired deformation of the subject tissue has taken place.

Abstract translation: 描述了用于重塑或重组组织的方法和装置，例如心脏的二尖瓣。 植入物包括大体上柔性的主体和多个磁性部分，使得磁性部分相互作用以引起植入物的形状的变化，这反过来影响对象组织的形状变化。 在一个示例中，至少一个植入物定位在冠状窦内以影响二尖瓣环的形状。 植入物可以进一步包括用于将植入物固定在容器内的固定机构，并且可以在已经发生主题组织的所需变形之后提供可移除性。

公开(公告)号：US20060212113A1

公开(公告)日：2006-09-21

申请号：US11361196

申请日：2006-02-23

Applicant: Samuel Shaolian ,  Emanuel Shaoulian ,  Michael Henson ,  Shahram Moaddeb

Inventor： Samuel Shaolian ,  Emanuel Shaoulian ,  Michael Henson ,  Shahram Moaddeb

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2250/0001 ,  A61F2250/001 ,  A61F2250/0065 ,  A61F2250/0069

Abstract: A device, method, and system for treating abdominal aortic aneurysms is described, where the device is an endovascular graft implant that one or more adjustable elements. The adjustable elements provide improved performance, for example, reduced leaking. The adjustable elements are adjustable within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. Examples of suitable types of energy include, for example, acoustic energy, radio frequency energy, light energy, and magnetic energy.

Abstract translation: 描述了用于治疗腹主动脉瘤的装置，方法和系统，其中装置是一个或多个可调节元件的血管内移植物植入物。 可调元件提供改进的性能，例如减少泄漏。 可调节元件可以以微创或非侵入性方式在患者体内可调节，例如通过经皮或外部给患者身体施加能量。 适当类型的能量的实例包括例如声能，射频能量，光能和磁能。

公开(公告)号：US20060015178A1

公开(公告)日：2006-01-19

申请号：US11181686

申请日：2005-07-14

Applicant: Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian ,  Michael Henson ,  Richard Rhee ,  Steven Anderson

Inventor： Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian ,  Michael Henson ,  Richard Rhee ,  Steven Anderson

IPC: A61F2/24

CPC classification number: A61F2/2442 ,  A61B17/3468 ,  A61B2017/00243 ,  A61F2/2451 ,  A61F2002/249 ,  A61F2210/0076

Abstract: Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.

Abstract translation: 提供组织成形方法和装置用于加强和/或改造心脏瓣膜。 在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。 这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。 在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。 形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。 形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。 在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。

公开(公告)号：US20050288783A1

公开(公告)日：2005-12-29

申请号：US11124415

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, a method for treating a cardiac valve includes providing an annuloplasty ring having a first size of a dimension in a first configuration and a second size of the dimension in a second configuration. In the first configuration, the method includes attaching the annuloplasty ring to or near a valve annulus in a heart. The method also includes applying energy from a magnetic resonance imaging device to the annuloplasty ring which responds to the energy by transforming from the first configuration to the second configuration.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，一种用于治疗心脏瓣膜的方法包括提供瓣环成形术环，所述环成形术环具有第一构型的尺寸的第一尺寸和在第二构造中尺寸的第二尺寸。 在第一构造中，该方法包括将瓣膜成形术环附接到心脏中的瓣膜环上或附近。 该方法还包括将能量从磁共振成像装置施加到瓣环成形术环，所述环成形术环通过从第一构型转变为第二构型来响应能量。

公开(公告)号：US20050288782A1

公开(公告)日：2005-12-29

申请号：US11124409

申请日：2005-05-06

Applicant: Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian

Inventor： Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。 能量吸收增强材料与所述形状记忆材料热连通。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。 身体构件被配置为响应于激活能量从第一配置变换到第二配置。 第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

公开(公告)号：US20050288781A1

公开(公告)日：2005-12-29

申请号：US11124408

申请日：2005-05-06

Applicant: Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian

Inventor： Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a ferromagnetic shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration. The body member is configured to be implanted into a heart so as to reinforce a cardiac valve annulus in the first configuration. The body member is configured to transform from the first configuration to the second configuration in vivo in response to a magnetic field. The body member in the second configuration is configured to reduce a size of the cardiac valve annulus.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括包括铁磁形状记忆材料的主体构件。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸。 身体构件被配置成植入心脏中，以便在第一构型中加强心脏瓣膜环。 身体构件被配置为响应于磁场在体内从第一配置转变为第二配置。 第二构造中的本体构件被构造成减小心脏瓣膜环的尺寸。