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    Process for preparing brevifoliol
    63.
    发明授权
    Process for preparing brevifoliol 有权
    短纤维酚的制备方法

    公开(公告)号：US07579491B2

    公开(公告)日：2009-08-25

    申请号：US11548166

    申请日：2006-10-10

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    IPC分类号： C07D305/00 ,  A61K36/13

    CPC分类号： C07C67/56 ,  C07C2603/30 ,  C07C69/78

    摘要： The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

    摘要翻译： 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。

    Process for the preparation of a extract rich in bacosides from the herb Bacopa monniera
    64.
    发明授权
    Process for the preparation of a extract rich in bacosides from the herb Bacopa monniera 失效
    从草药Bacopa monniera制备富含芽孢杆菌的提取物的方法

    公开(公告)号：US06833143B1

    公开(公告)日：2004-12-21

    申请号：US10400192

    申请日：2003-03-26

    申请人： Atul Prakash Kahol ,  Tarun Singh ,  Sudeep Tandon ,  Madan Mohan Gupta ,  Suman Preet Singh Khanuja

    发明人： Atul Prakash Kahol ,  Tarun Singh ,  Sudeep Tandon ,  Madan Mohan Gupta ,  Suman Preet Singh Khanuja

    IPC分类号： A61K3578

    CPC分类号： A61K36/80

    摘要： The present invention provides a novel process for the preparation of bacosides enriched fraction in a non-hygroscopic form the extract of Bacopa monniera, the said process comprising the steps of drying freshly harvested herb in a hot air oven at 37-42° C., powdering and sieving the dried herb to obtain powder of 30-40 mesh size, defatting the powdered herb with hexane in a modified soxhlet extractor, extracting the defatted powdered herb with acetone, again extracting the same herb with methanol to obtain an extract containing bacosides, concentrating the extract to one twentieth of its original volume under reduced pressure, gradually adding the concentrated extract to acetone for precipitating the bacosides, filtering the bacosides in a Nutsche type vacuum filter, dissolving the crude bacoside mass into 2-10 parts water, extracting the bacoside solution with n-butanol to selectively transfer the bacosides to the solvent phase, separating and concentrating the solvent phase under vacuum to obtain semi-dry mass, dissolving the semi dried mass into 2-10 parts water, adding and stirring 1-5% of &bgr;-cyclodextrin to stabilize the bacosides, spray drying the stabilized bacoside solution by maintaining hot air temperature at 90-110° C., to obtain a stable free flowing fraction of Bacopa monniera rich in bacosides.

    摘要翻译： 本发明提供了一种用于制备以非吸湿形式的Bacopa monniera提取物富集杆菌的部分的新方法，所述方法包括以下步骤：在37-42℃的热空气烘箱中干燥新鲜收获的草本植物， 粉碎和筛分干草，得到30-40目尺寸的粉末，用改性索氏提取器用己烷脱脂粉末，用丙酮提取脱脂粉末草药，再次用甲醇提取相同的草本，得到含有药剂的提取物， 将提取物在减压下浓缩至其原始体积的二十分之一，逐渐将浓缩提取物加入到丙酮中沉淀芽孢杆菌，过滤Nutsche型真空过滤器中的芽孢杆菌，将粗制药物块溶解在2-10份水中， 使用正丁醇选择性转移杆菌苷至溶剂相，分离和浓缩溶剂相 获得半干质量，将半干质量溶解在2-10份水中，加入并搅拌1-5％的β-环糊精以稳定芽孢杆菌，通过将热空气温度保持在90℃喷雾干燥稳定的bacoside溶液， 110℃，以获得富含芽孢杆菌的Bacopa monniera的稳定的自由流动分数。