Process for the production of vasicine
    3.
    发明授权
    Process for the production of vasicine 失效
    生产vasicine的过程

    公开(公告)号:US06676976B2

    公开(公告)日:2004-01-13

    申请号:US10104765

    申请日:2002-03-21

    IPC分类号: A61K3578

    CPC分类号: C07D487/04

    摘要: The present invention relates to an improved process for the production of vasicine of formula (1) from the Adhatoda vasica, said process comprising the steps of: extracting the dried and pulverized leaves with an alcoholic extract at an ambient temperature, concentrating the alcoholic extract to obtain a concentrated extract, treating and stirring extract with an aqueous organic acid for 2-24 hours, extracting the acid solution of with an organic solvent, separating the organic layer and aqueous acidic layer, basifying the aqueous acidic solution with a base, extracting the basified solution with an organic solvent, separating the organic layer, drying and filtering, evaporating the organic layer to obtain an amorphous residue, and treating the amorphous residue with an organic solvent or mixture of organic solvents to obtain vasicine.

    摘要翻译: 本发明涉及一种用于从Adhatoda vasica生产式(1)的维生素的改进方法,所述方法包括以下步骤:在室温下用醇提取物萃取干燥和粉碎的叶子,将醇提取物浓缩 获得浓缩提取物,用有机酸水溶液处理和搅拌提取物2-24小时,用有机溶剂萃取酸溶液,分离有机层和酸性水层,用碱将酸性水溶液碱化,提取 碱性溶液与有机溶剂分离,分离有机层,干燥和过滤,蒸发有机层,得到无定形残渣,用有机溶剂或有机溶剂混合物处理无定形残余物,得到vasicine。