公开(公告)号：US06673749B1

公开(公告)日：2004-01-06

申请号：US10335104

申请日：2002-12-31

申请人： Anil Kumar Singh ,  Guru Das Bagchi ,  Sarita Singh ,  Prem Dutt Dwivedi ,  Anil Kumar Gupta ,  Suman Preet Singh Khanuja

发明人： Anil Kumar Singh ,  Guru Das Bagchi ,  Sarita Singh ,  Prem Dutt Dwivedi ,  Anil Kumar Gupta ,  Suman Preet Singh Khanuja

IPC分类号： A01N3106

CPC分类号： A01N45/00 ,  A01N65/22

摘要： The present invention provides plant growth-promoting activities of natural plant active constituent calliterpenone and its derivatives belonging to the group phyllocladane diterpenoids. These phytochemicals and derivatives exhibit remarkable growth promoting activities on plant roots, shoots and promote seed germination both in monocotyledonous and dicotyledonous plants. These phytomolecules possess the antagonistic activity against allelochemicals of plant growth retardant nature and hence can be used to alleviate their detrimental effects.

摘要翻译： 本发明提供植物生长促进活性的天然植物活性成分愈伤组蛋白及其衍生物属于叶绿素二萜类化合物。 这些植物化学物质和衍生物在单子叶植物和双子叶植物中表现出显着的生长促进活性，植物根，芽和促进种子发芽。 这些植物分子具有抗植物生长阻滞性质的化学物质的拮抗作用，因此可用于缓解其有害影响。

公开(公告)号：US07446243B2

公开(公告)日：2008-11-04

申请号：US10647114

申请日：2003-08-25

申请人： Anil Kumar Gupta ,  Suman Preet Singh Khanuja ,  Madan Mohan Gupta ,  Ajit Kumar Shasany ,  Neeraj Jain ,  Ram Kishor Verma ,  Mahendra Pandurang Darokar ,  Guru Das Bagchi ,  Sushil Kumar

发明人： Anil Kumar Gupta ,  Suman Preet Singh Khanuja ,  Madan Mohan Gupta ,  Ajit Kumar Shasany ,  Neeraj Jain ,  Ram Kishor Verma ,  Mahendra Pandurang Darokar ,  Guru Das Bagchi ,  Sushil Kumar

IPC分类号： A01H5/00

CPC分类号： A01H6/38 ,  A01H5/02

摘要： The present invention relates to a cultivar of Phyllanthus amarus ‘CIM-Jeevan’, producing high amount of herb, phyllanthin and hypophyllanthin, wherein said cultivar is developed through γ-irradiation of superior germplasm, the said plant produces high amount of herbage yield ranging between 1.0-1.15 kg per sqm fresh total plant herb, possesses high vegetative erect growth with a height ranging between 60 to 65 cm, produces phyllanthin ranging between 0.70-0.77% in dry herb, produces hypophyllanthin ranging between 0.32-0.37% in dry herb, and shows seed germination of about 90%.

摘要翻译： 本发明涉及一种栽培品种，其中生产大量草本植物，叶绿素和叶绿素，其中所述栽培种通过优质种质的γ-照射而发育，所述植物产生大量的草本产量， 每平方米新鲜总草药1.0-1.15公斤，高度植物性直立生长，高度在60至65厘米之间，产生干草中0.1-0.77％的叶绿素，在干草中产生0.32-0.37％的叶绿素， 并显示种子发芽率约90％。

公开(公告)号：US07375260B2

公开(公告)日：2008-05-20

申请号：US11334333

申请日：2006-01-18

申请人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Anil Kumar Gupta ,  Mahendra Pandurang Darokar ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Govind Ram ,  Anuraddha Kumar ,  Raj Kishori Lal ,  Ravi Prakash Bansal ,  Anil Kumar Singh ,  Rajendra Singh Bhakuni ,  Sudeep Tandon

发明人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Anil Kumar Gupta ,  Mahendra Pandurang Darokar ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Govind Ram ,  Anuraddha Kumar ,  Raj Kishori Lal ,  Ravi Prakash Bansal ,  Anil Kumar Singh ,  Rajendra Singh Bhakuni ,  Sudeep Tandon

IPC分类号： A01H5/00

CPC分类号： A01H6/14 ,  A01H5/02

摘要： The present invention is related to the development of a novel, distinct high herb and artemisinin yielding genotype of Artemisia annua obtained through systematic marker assisted breeding followed by selection of uniform population in a methodical way wherein the genotype is distinct, uniform and stably maintainable by continuous rouging of off types in the population using DNA marker at early seedling stage from nursery itself and suitable for commercial cultivation.

摘要翻译： 本发明涉及通过系统标记辅助育种获得的一种新颖，不同的高草药和青蒿素产生的​​青蒿素基因型的发展，随后以有条理的方式选择均匀群体，其中基因型是不同的，均匀的并且可持续地通过连续的维持 在幼苗本身早期苗期使用DNA标记对群体中的种类进行粗糙化，适合商业种植。

公开(公告)号：US07527814B2

公开(公告)日：2009-05-05

申请号：US11699764

申请日：2007-01-30

申请人： Anil Kumar Singh ,  Suman Preet Singh Khanuja ,  Sudeep Tandon ,  Alok Kalra ,  Deeptanjali Sahoo ,  Atul Prakash Kahol ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Arun Kumar Kukreja ,  Mansoor Alam ,  Guru Das Bagachi ,  Ravi Prakash Bansal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta

发明人： Anil Kumar Singh ,  Suman Preet Singh Khanuja ,  Sudeep Tandon ,  Alok Kalra ,  Deeptanjali Sahoo ,  Atul Prakash Kahol ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Arun Kumar Kukreja ,  Mansoor Alam ,  Guru Das Bagachi ,  Ravi Prakash Bansal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta

IPC分类号： A61K36/00

CPC分类号： A01N65/22 ,  A01N65/00 ,  B01D11/0288 ,  Y02A40/143 ,  A01N2300/00

摘要： The invention provides a simple method for isolation of calliterpenone (16α,17 dihydroxy-3-oxo phyllocladane), a phyllocladane diterpenoid with the plant growth regulating properties, from plant genus Callicarpa.

摘要翻译： 本发明提供了一种用于从植物属Callicarpa分离具有植物生长调节性质的叶绿素二烯酮（16α，17二羟基-3-氧基十二烷）的简单方法。

公开(公告)号：US20110092585A1

公开(公告)日：2011-04-21

申请号：US12874065

申请日：2010-09-01

申请人： Suman Preet Singh Khanuja ,  Anirban Pal ,  Sunil Kumar Chattopadhyay ,  Mahendra Pandurang Darokar ,  Rajendra Prasad Patel ,  Anil Kumar Gupta ,  Arvind Singh Negi ,  Tanpreet Kaur ,  Sudeep Tandon ,  Atul Prakash Kahol ,  Ankur Garg

发明人： Suman Preet Singh Khanuja ,  Anirban Pal ,  Sunil Kumar Chattopadhyay ,  Mahendra Pandurang Darokar ,  Rajendra Prasad Patel ,  Anil Kumar Gupta ,  Arvind Singh Negi ,  Tanpreet Kaur ,  Sudeep Tandon ,  Atul Prakash Kahol ,  Ankur Garg

IPC分类号： A61K31/366 ,  A61P37/02

CPC分类号： A61K31/37 ,  A61K2300/00

摘要： The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscosa along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.

摘要翻译： 本发明提供了一种新型药物组合物，其由从植物Cleome viscosa的种子分离的三种分子式1,2和3的香豆素类结合物以及可用作免疫调节剂的药学上可接受的载体组合。 本发明还描述了化合物调节幽门和细胞介导的免疫应答的能力。 它进一步提供了以优化的比例制备所述三种香豆素类黄酮的新型药物组合物以调节幽门和细胞介导的免疫应答的方法。

公开(公告)号：US07435877B2

公开(公告)日：2008-10-14

申请号：US10913792

申请日：2004-08-06

申请人： Suman Preet Singh Khanuja ,  Raj Kishori Lal ,  Arun Kumar Agnihotri ,  Ajit Kumar Shasany ,  Ali Arif Naqvi ,  Samresh Dwivedi ,  Hari Om Misra ,  Om Prakesh Dhawan ,  Alok Kalra ,  Aparbal Singh ,  Janak Raj Bahl ,  Saudan Singh ,  Dharani Dhar Patra ,  Shilpi Agarwal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta ,  Moti Lal Gupta ,  Ram Chandra

发明人： Suman Preet Singh Khanuja ,  Raj Kishori Lal ,  Arun Kumar Agnihotri ,  Ajit Kumar Shasany ,  Ali Arif Naqvi ,  Samresh Dwivedi ,  Hari Om Misra ,  Om Prakesh Dhawan ,  Alok Kalra ,  Aparbal Singh ,  Janak Raj Bahl ,  Saudan Singh ,  Dharani Dhar Patra ,  Shilpi Agarwal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta ,  Moti Lal Gupta ,  Ram Chandra

IPC分类号： A01H5/00 ,  A01H5/10

CPC分类号： A01H5/12

摘要： Indian basil, Ocimum basilicum, belongs to the family of Lamiaceae. The essential oil of Indian basil extracted via hydro or steam distillation from the leaves or whole plants is used to flavor foods, dental and oral products, in fragrances, and in traditional rituals and medicines. Extracted essential oil has also been shown to contain biologically active constituents that are insecticidal, nematicidal, fungistatic or which have antimicrobial properties. The present invention relates to the development of an early, short duration, dwarf, high essential oil, methy chavicol and linalool yielding variety of Indian basil (Ocimum basilicum). Family—Lamiaceae) named as ‘CIM-SAUMYA’. This new variety of Indian basil was developed through open pollination in the germplasm followed by half-sib progeny selection and evaluation for the yield characters of selected population for 3 years in field conditions. The new cultivar possesses better growth and vegetative growth and is able to produce higher herbage, oil and better combination of methyl chavicol and linalool yield per unit area as compared to other control genotypes.

摘要翻译： 印度罗勒，罗勒属，属于百叶科科。 通过水蒸气或蒸汽蒸馏从叶子或整个植物中提取的印度罗勒香精油用于调味香料中的食物，牙科和口服产品，以及传统的仪式和药物。 提取的精油也显示含有具有杀虫，杀线虫，抑菌或具有抗微生物特性的生物活性成分。 本发明涉及印度罗勒（Ocimum basilicum）的早期，短期，矮化，高精油，甲基切瓦克醇和里哪醇生产品种的发展。 名为“CIM-SAUMYA”的家庭 - 唇形科）。 这种新种类的印度罗勒是通过在种质上的开放授粉开发的，然后进行半同胞后代选择，并对现场条件下所选群体的产量特征进行评估3年。 与其他对照基因型相比，新品种具有更好的生长和营养生长，能够产生更高的草药，油和更好的单位面积甲基切维醇和芳樟醇产量的组合。

公开(公告)号：US09018226B2

公开(公告)日：2015-04-28

申请号：US13262040

申请日：2010-03-31

申请人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Dnyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

发明人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Dnyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

IPC分类号： A61K31/4375 ,  C07D491/22 ,  A61K36/24

CPC分类号： A61K36/24

摘要： The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS).

摘要翻译： 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异孢子甲苯胺，10-脱甲氧基甲苯胺，11-脱甲氧基苯甲苯胺，保留物和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自萝卜（Rauwolfia tetraphylla）的叶的式1和2的生物碱的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。

公开(公告)号：US20120184576A1

公开(公告)日：2012-07-19

申请号：US13262040

申请日：2010-03-31

申请人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

发明人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

IPC分类号： A61K31/4375 ,  C07D455/00 ,  A61P25/18 ,  A61K31/475

CPC分类号： A61K36/24

摘要： The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-derαethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 1. R1=R2=OMe R3=β-H (Isoreserpiline) 2. R1=R2=OMe R3=β-H (Reserpiline) ″3. R1=OMe R2=HR3=β-H (11-Demethoxy reserpiline) ″4.R1=H R2=OMe R3=β-H (10-Demethoxy reserpiline) ″5. R1=R2=H R3=α-H (Tetrahydroalstonine) *7. R1=OMe R2=H R3=α-H (10-Methoxytetrahudroalstonine).

摘要翻译： 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱中的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异丙基苯胺，10-脱乙氧基去甲苯胺，11-去甲氧基甲苯吡胺，储存蛋白和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自罗非草（Rauwolfia tetraphylla）的叶子的式1和2的烷烃的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。 R1 = R2 = OMe R3 =＆bgr; -H（Isoreserpiline）2.R1 = R2 = OMe R3 =＆bgr; -H（Reserpiline）“3。 R1 = OMe R2 = HR3 =＆bgr; -H（11-甲氧基乙酰胺）“4.R1 = H R2 = OMe R3 =＆bgr; -H（10-甲氧基乙胺） R1 = R2 = H R3 =α-H（四氢奥斯汀）* 7。 R1 = OMe R2 = H R3 =α-H（10-甲氧基四胡司汀）。

公开(公告)号：US08620885B1

公开(公告)日：2013-12-31

申请号：US12706041

申请日：2010-02-16

申请人： Anil Kumar Gupta ,  David James Hubbard ,  Jerome Frank Winzig

发明人： Anil Kumar Gupta ,  David James Hubbard ,  Jerome Frank Winzig

IPC分类号： G06F17/00

CPC分类号： G06Q10/04 ,  G06Q50/06

摘要： Many public utilities companies employ meter data management systems (MDMSs) to manage the millions and sometimes billions of daily and interval meter read values that they collect during a single billing period. One problem with some MDMSs estimate missing daily reads based on average daily usage and these estimates do not match daily usage values determined from interval read data, causing sum check exceptions. Such exceptions are undesirable because they can lead to billing errors and lost consumer confidence in the utility, among other things. To address this, the present inventors devised an exemplary system that uses good and estimated interval read data to more accurately estimate the missing daily reads and thereby reduce occurrences of sum check exceptions. The exemplary system also estimates missing time of use and demand data based on interval read data.

摘要翻译： 许多公用事业公司采用仪表数据管理系统（MDMS）来管理在单个计费周期内收集的数百万甚至数十亿的每日和间隔表读取值。 一些MDMS的一个问题是根据平均每日使用量估计缺少每日读数，这些估计值与从间隔读取数据确定的日常使用值不符，导致总和检查异常。 这种例外是不合需要的，因为它们可能导致计费错误，并导致消费者对公用事业的信心。 为了解决这个问题，本发明人设计了一种示例性系统，其使用良好和估计的间隔读取数据来更准确地估计丢失的每日读取，从而减少和检查异常的发生。 示例性系统还基于间隔读取数据估计丢失使用时间和需求数据。

公开(公告)号：US20130203711A1

公开(公告)日：2013-08-08

申请号：US13821016

申请日：2011-10-04

申请人： Anil Kumar Gupta

发明人： Anil Kumar Gupta

IPC分类号： A61K31/618 ,  A61K31/045

CPC分类号： A61K31/618 ,  A61K31/045 ,  A61K31/60 ,  A61K36/15 ,  A61K36/185 ,  A61K36/45 ,  A61K36/61 ,  A61K36/63 ,  A61K36/738 ,  A61K2300/00

摘要： The invention relates to a herbal oil, for controlling blood sugar without risk of hypoglycemia, comprising of the step of (i) fractional distillation of essential oils comprising of turpentine oil, jasmine oil, rose oil, eucalyptus oil, sandal wood oil and water green oil to obtain hydroxyl compounds #-terpinol, linalool, Gereneol, Citroneoll, #-Santalol, Methyl salicylate and other alcoholic terpenoils and (ii) dilution with fat oil so as to have approximate weight percentage of #-terpinol 50%, linalool 6%, Gereneol 4%, Citroneoll 3.5%, #-Santalol 2.7%, Methyl salicylate 2%, other alcoholic terpenoils and fat oil 31.8%.

摘要翻译： 本发明涉及一种用于控制没有低血糖风险的血糖的草药油，其包括以下步骤：（i）将包含松节油，茉莉油，玫瑰油，桉树油，凉鞋木油和水绿色的精油分馏 油，得到羟基化合物＃-terpinol，芳樟醇，Gereneol，Citroneoll，＃-Santalol，水杨酸甲酯和其他酒精萜烯，和（ii）用脂肪油稀释，使其约占重量百分比为#-固辛醇50％，芳樟醇6％ ，Gereneol 4％，Citroneoll 3.5％，＃-Santalol 2.7％，水杨酸甲酯2％，其他酒精萜烯和脂肪油31.8％。